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Front Physiol：TRIP-1促进包含细胞外囊泡和调节血管生成因子的ECM的组装

2018-09-11 MedSci MedSci原创

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转化生长因子β受体II相互作用蛋白-1（TRIP-1）定位于骨和牙本质的矿化基质中。TRIP-1在ECM中的功能尚未可知，已知其在蛋白质合成期间起细胞内内质网蛋白的作用。基于其在骨骼和牙齿中的定位模式，我们认为TRIP-1在矿化过程中起到多种功能的调节蛋白的作用。 使用重组TRIP-1和TRIP-1过表达并敲除嵌入3D仿生支架中的细胞植入体内确定TRIP-1的体内功能。4周后，过表达TRIP

转化生长因子β受体II相互作用蛋白-1（TRIP-1）定位于骨和牙本质的矿化基质中。TRIP-1在ECM中的功能尚未可知，已知其在蛋白质合成期间起细胞内内质网蛋白的作用。基于其在骨骼和牙齿中的定位模式，我们认为TRIP-1在矿化过程中起到多种功能的调节蛋白的作用。

使用重组TRIP-1和TRIP-1过表达并敲除嵌入3D仿生支架中的细胞植入体内确定TRIP-1的体内功能。4周后，过表达TRIP-1的细胞和含有重组TRIP-1的支架在皮下组织中几种ECM蛋白（如纤连蛋白和胶原蛋白I）的表达水平更高。Picrosirius红色和偏振显微镜用于识别细胞外基质（ECM）中胶原原纤维的双折射。

有趣的是，敲低TRIP-1导致纤连蛋白降低和ERK MAP激酶活化的下调。进一步研究发现TRIP-1过表达导致促血管生成标记VEGF的更高表达和抗血管生成因子，如色素上皮衍生因子和血小板反应蛋白的下调。场发射扫描电子显微镜结果表明TRIP-1过表达细胞释放大量细胞外微泡，其位于ECM中的纤维基质上。

总体而言，该研究表明TRIP-1可促进细胞外囊泡的分泌，关键成骨ECM基质蛋白的合成和促进血管生成。

原始出处：

Yinghua Chen, Anne George. TRIP-1 Promotes the Assembly of an ECM That Contains Extracellular Vesicles and Factors That Modulate Angiogenesis. Front Physiol. 2018; 9: 1092.

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    2019-06-14 cmj8wellington

    #Physio#

    0

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    2018-09-12 bnjfx@129.com

    #细胞外囊泡#

    0

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    2018-09-12 charl1234573

    #囊泡#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1788871, encodeId=07391e888719f, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Jun 14 01:15:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493580, encodeId=c6a61493580c6, content=<a href='/topic/show?id=36dfe7869dd' target=_blank style='color:#2F92EE;'>#细胞外囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77869, encryptionId=36dfe7869dd, topicName=细胞外囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e979073459, createdName=bnjfx@129.com, createdTime=Wed Sep 12 16:15:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599841, encodeId=5235159984186, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Wed Sep 12 16:15:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344508, encodeId=044e34450803, content=嗯嗯，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Tue Sep 11 12:00:06 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344498, encodeId=a1e334449893, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Sep 11 10:35:05 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344466, encodeId=f4f0344466cd, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Sep 11 08:06:03 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344457, encodeId=870234445e03, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Sep 11 06:43:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344449, encodeId=abc53444495e, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Sep 11 05:31:23 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344445, encodeId=fa9a34444597, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Tue Sep 11 01:32:22 CST 2018, time=2018-09-11, status=1, ipAttribution=)]
    2018-09-11 liumin1987

    嗯嗯，学习了。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1788871, encodeId=07391e888719f, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Jun 14 01:15:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493580, encodeId=c6a61493580c6, content=<a href='/topic/show?id=36dfe7869dd' target=_blank style='color:#2F92EE;'>#细胞外囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77869, encryptionId=36dfe7869dd, topicName=细胞外囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e979073459, createdName=bnjfx@129.com, createdTime=Wed Sep 12 16:15:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599841, encodeId=5235159984186, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Wed Sep 12 16:15:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344508, encodeId=044e34450803, content=嗯嗯，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Tue Sep 11 12:00:06 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344498, encodeId=a1e334449893, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Sep 11 10:35:05 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344466, encodeId=f4f0344466cd, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Sep 11 08:06:03 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344457, encodeId=870234445e03, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Sep 11 06:43:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344449, encodeId=abc53444495e, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Sep 11 05:31:23 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344445, encodeId=fa9a34444597, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Tue Sep 11 01:32:22 CST 2018, time=2018-09-11, status=1, ipAttribution=)]
    2018-09-11 lietome24

    好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1788871, encodeId=07391e888719f, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Jun 14 01:15:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493580, encodeId=c6a61493580c6, content=<a href='/topic/show?id=36dfe7869dd' target=_blank style='color:#2F92EE;'>#细胞外囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77869, encryptionId=36dfe7869dd, topicName=细胞外囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e979073459, createdName=bnjfx@129.com, createdTime=Wed Sep 12 16:15:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599841, encodeId=5235159984186, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Wed Sep 12 16:15:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344508, encodeId=044e34450803, content=嗯嗯，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Tue Sep 11 12:00:06 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344498, encodeId=a1e334449893, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Sep 11 10:35:05 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344466, encodeId=f4f0344466cd, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Sep 11 08:06:03 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344457, encodeId=870234445e03, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Sep 11 06:43:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344449, encodeId=abc53444495e, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Sep 11 05:31:23 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344445, encodeId=fa9a34444597, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Tue Sep 11 01:32:22 CST 2018, time=2018-09-11, status=1, ipAttribution=)]
    2018-09-11 kafei

    学习了谢谢

    0

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    2018-09-11 1209e435m98(暂无昵称)

    学习了，谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1788871, encodeId=07391e888719f, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Jun 14 01:15:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493580, encodeId=c6a61493580c6, content=<a href='/topic/show?id=36dfe7869dd' target=_blank style='color:#2F92EE;'>#细胞外囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77869, encryptionId=36dfe7869dd, topicName=细胞外囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e979073459, createdName=bnjfx@129.com, createdTime=Wed Sep 12 16:15:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599841, encodeId=5235159984186, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Wed Sep 12 16:15:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344508, encodeId=044e34450803, content=嗯嗯，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Tue Sep 11 12:00:06 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344498, encodeId=a1e334449893, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Sep 11 10:35:05 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344466, encodeId=f4f0344466cd, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Sep 11 08:06:03 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344457, encodeId=870234445e03, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Sep 11 06:43:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344449, encodeId=abc53444495e, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Sep 11 05:31:23 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344445, encodeId=fa9a34444597, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Tue Sep 11 01:32:22 CST 2018, time=2018-09-11, status=1, ipAttribution=)]
    2018-09-11 yjs木玉

    好好好好好好好好

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1788871, encodeId=07391e888719f, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Jun 14 01:15:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493580, encodeId=c6a61493580c6, content=<a href='/topic/show?id=36dfe7869dd' target=_blank style='color:#2F92EE;'>#细胞外囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77869, encryptionId=36dfe7869dd, topicName=细胞外囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e979073459, createdName=bnjfx@129.com, createdTime=Wed Sep 12 16:15:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599841, encodeId=5235159984186, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Wed Sep 12 16:15:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344508, encodeId=044e34450803, content=嗯嗯，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Tue Sep 11 12:00:06 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344498, encodeId=a1e334449893, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Sep 11 10:35:05 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344466, encodeId=f4f0344466cd, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Sep 11 08:06:03 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344457, encodeId=870234445e03, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Sep 11 06:43:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344449, encodeId=abc53444495e, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Sep 11 05:31:23 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344445, encodeId=fa9a34444597, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Tue Sep 11 01:32:22 CST 2018, time=2018-09-11, status=1, ipAttribution=)]
    2018-09-11 lofter

    学习了感谢分享

    0

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