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Can J Gastroenterol Hepatol:粪便微生物群移植(FMT)与富含乳酸菌的FMT在治疗复发性艰难梭菌感染中肠道微生物群的改变

2020-12-16 MedSci原创 MedSci原创

近日,一项双盲随机比较的双臂试点多中心研究对比了粪便微生物群移植(FMT)与FMT联合乳酸菌(FMT-L)治疗复发性艰难梭菌感染(R-CDI)的疗效和肠道微生物群的差异。

近日,一项双盲随机比较的双臂试点多中心研究对比了粪便微生物群移植(FMT)与FMT联合乳酸菌(FMT-L)治疗复发性艰难梭菌感染(R-CDI)的疗效和肠道微生物群的差异,研究结果已在线发表于Can J Gastroenterol Hepatol。

研究纳入了21名患者(FMT组13人,FMT-L组8人),从研究开始对21例患者进行了为期90天的随访。从选定的患者中,在治疗后的第0天、第3天、第7天和第28天获得粪便样本。通过16S rRNA测序分析粪便样本和FMT。

 

总的来说,两组每天的排便量都有所减少,从最初48小时的8.6次减少到3.2次(减少62.7%,p=0.001)。没有严重的不良反应或复发的记录。Firmicutes是供体中最丰富的门类。检测到蛋白菌的相对丰度较低,且大多存在于患者中,甚至比例高于供体。捐献者的菌池中也有相对较少的Bacteroidetes,部分患者中该门类的丰度较高。根据ANOSIM R值,基底样品和第7天(P=0.045)和第28天(0.041)采集的样品的微生物群落有显著差异。

综上所述,该研究结果表明,传统FMT和富含乳酸菌的FMT在临床和基因组上相似,在第7天和第28天观察到细菌多样性的恢复,以及菌群失调问题的解决。首次复发的患者接受FMT治疗后反应良好,无严重不良反应;在R-CDI期间应考虑将FMT作为早期治疗。

 

原始出处:

 

Elvira Garza-González, Soraya Mendoza-Olazarán, et al., Intestinal Microbiome Changes in Fecal Microbiota Transplant (FMT) vs. FMT Enriched with Lactobacillus in the Treatment of Recurrent Clostridioides difficile Infection. Can J Gastroenterol Hepatol. 2019 Dec 28;2019:4549298. doi: 10.1155/2019/4549298.  

 

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  5. 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    2021-05-15 ms8000000228605912

    #肿瘤#是这样吗?

    0

  6. 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  7. 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time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073193, encodeId=606220e31930c, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Sep 25 03:41:32 CST 2021, time=2021-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427475, encodeId=be8d142e4759d, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Dec 17 11:41:32 CST 2020, time=2020-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466953, encodeId=cc9a146695361, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Thu Dec 17 11:41:32 CST 2020, time=2020-12-17, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1909858, encodeId=59cd1909858d0, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Fri May 21 00:41:32 CST 2021, time=2021-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748358, encodeId=21651e48358da, content=<a href='/topic/show?id=a8754255624' target=_blank style='color:#2F92EE;'>#复发性艰难梭菌感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42556, encryptionId=a8754255624, topicName=复发性艰难梭菌感染)], attachment=null, authenticateStatus=null, createdAvatar=null, 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time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073193, encodeId=606220e31930c, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Sep 25 03:41:32 CST 2021, time=2021-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427475, encodeId=be8d142e4759d, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Dec 17 11:41:32 CST 2020, time=2020-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466953, encodeId=cc9a146695361, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Thu Dec 17 11:41:32 CST 2020, time=2020-12-17, status=1, ipAttribution=)]
    2021-09-25 许安
  9. 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time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073193, encodeId=606220e31930c, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Sep 25 03:41:32 CST 2021, time=2021-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427475, encodeId=be8d142e4759d, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Dec 17 11:41:32 CST 2020, time=2020-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466953, encodeId=cc9a146695361, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Thu Dec 17 11:41:32 CST 2020, time=2020-12-17, status=1, ipAttribution=)]
    2020-12-17 gwc384
  10. 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createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Dec 17 11:41:32 CST 2020, time=2020-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466953, encodeId=cc9a146695361, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Thu Dec 17 11:41:32 CST 2020, time=2020-12-17, status=1, ipAttribution=)]
    2020-12-17 Homburg

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本研究旨在评估乳酸菌与重度牙周炎辅助治疗效果、牙周参数、口臭的临床关联,研究结果已在线发表于Am J Dent。

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膀胱过度活动症(OAB)是一种以尿急症状为特征的症候群,常伴有尿频和夜尿症状,可伴或不伴有急迫性尿失禁。OAB在中国的患病率为15.1%,比糖尿病(6%)更常见。大大降低了中老年女性的生活质量。

乳酸菌可“激活”人体免疫系统 多喝酸奶有益处

为何食用酸奶有益人体健康?德国一项新研究发现,人类和类人猿细胞中存在的一种受体,可探测到发酵食物中常见细菌乳酸菌的代谢产物,与之结合后可发出信号“激活”免疫系统。

Benef Microbes:LAB胶囊具有良好的耐受性,可作为恢复性活跃女性阴道乳酸菌的适当替代品

益生菌配方中的阴道乳酸菌(LAB)构成了微生物组重建以及预防和治疗泌尿生殖系统感染的一种有前途的选择。我们进行了一项双盲、随机临床试验,以评估健康性活跃女性阴道给药的LAB-胶质胶囊的安全性,研究结果

Am J Dent:乳酸菌治疗严重牙周炎和口臭的临床效果

本研究旨在评价乳酸菌与重症牙周炎辅助治疗效果、牙周参数、口臭的临床关联。

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