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Drug Des Devel Ther:促红细胞生成素可促进牙周韧带干细胞的增殖与分化

2019-09-03 不详 网络

本研究旨在检测促红细胞生成素(EPO)在调节牙周韧带干细胞(PDLSCs)的增殖和成骨分化中的作用,并分析这些过程的潜在信号。分离并表征PDLSC。用β-连环蛋白shRNA转染PDLSC。qRT-PCR和Western印迹分析用于检查EPO对PDLSC中成骨相关基因和蛋白(Runx2,OCN和Osterix)表达的成骨作用。茜素红S染色用于检测矿化的结节形成。此外,研究了Wnt/β-连环蛋白通路与

本研究旨在检测促红细胞生成素(EPO)在调节牙周韧带干细胞(PDLSCs)的增殖和成骨分化中的作用,并分析这些过程的潜在信号。

分离并表征PDLSC。用β-连环蛋白shRNA转染PDLSC。qRT-PCR和Western印迹分析用于检查EPO对PDLSC中成骨相关基因和蛋白(Runx2,OCN和Osterix)表达的成骨作用。茜素红S染色用于检测矿化的结节形成。此外,研究了Wnt/β-连环蛋白通路与EPO对PDLSCs成骨作用的关系。

结果表明,EPO对PDLSCs发挥积极的成骨作用。EPO可显著降低PDLSCs的生长,并以剂量依赖的方式增加碱性磷酸酶活性和钙沉积。 EPO给药后Runx2,Osterix和OCN的表达增加。 EPO增加PDLSC中的β-连环蛋白和细胞周期蛋白D1。转染β-catenin shRNA后,EPO对PDLSCs的成骨作用减弱。

总之,该研究结果表明,EPO促进PDLSC的成骨分化,潜在的机制可以是激活Wnt /β-连环蛋白信号传导通路。

原始出处:

Zheng DH, Wang XX, et al., Erythropoietin enhances osteogenic differentiation of human periodontal ligament stem cells via Wnt/β-catenin signaling pathway. Drug Des Devel Ther. 2019 Jul 26;13:2543-2552. doi: 10.2147/DDDT.S214116. eCollection 2019.

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    2019-10-14 fzwish20000
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time=2019-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558522, encodeId=0ea615585228d, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Thu Sep 05 14:20:00 CST 2019, time=2019-09-05, status=1, ipAttribution=)]
    2020-01-23 wangbingxhy
  5. 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content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Sep 05 14:20:00 CST 2019, time=2019-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507439, encodeId=29fe150e439c6, content=<a href='/topic/show?id=16b7100010c7' target=_blank style='color:#2F92EE;'>#韧带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100010, encryptionId=16b7100010c7, topicName=韧带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9b19890064, createdName=juliusluan81, createdTime=Thu Sep 05 14:20:00 CST 2019, time=2019-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558522, encodeId=0ea615585228d, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Thu Sep 05 14:20:00 CST 2019, time=2019-09-05, status=1, ipAttribution=)]
    2019-09-06 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

  6. 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  7. 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time=2019-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558522, encodeId=0ea615585228d, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Thu Sep 05 14:20:00 CST 2019, time=2019-09-05, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1674652, encodeId=59be16e4652e6, content=<a href='/topic/show?id=cf486e550bd' target=_blank style='color:#2F92EE;'>#牙周韧带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67550, encryptionId=cf486e550bd, topicName=牙周韧带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6a227038762, createdName=w363522458, createdTime=Wed Oct 02 05:20:00 CST 2019, time=2019-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1982318, encodeId=4c67198231839, content=<a href='/topic/show?id=13b658e849' target=_blank style='color:#2F92EE;'>#Dev#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5878, encryptionId=13b658e849, topicName=Dev)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, 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content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Sep 05 14:20:00 CST 2019, time=2019-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507439, encodeId=29fe150e439c6, content=<a href='/topic/show?id=16b7100010c7' target=_blank style='color:#2F92EE;'>#韧带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100010, encryptionId=16b7100010c7, topicName=韧带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9b19890064, createdName=juliusluan81, createdTime=Thu Sep 05 14:20:00 CST 2019, time=2019-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558522, encodeId=0ea615585228d, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Thu Sep 05 14:20:00 CST 2019, time=2019-09-05, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1674652, encodeId=59be16e4652e6, content=<a href='/topic/show?id=cf486e550bd' target=_blank style='color:#2F92EE;'>#牙周韧带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67550, encryptionId=cf486e550bd, topicName=牙周韧带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6a227038762, createdName=w363522458, createdTime=Wed Oct 02 05:20:00 CST 2019, time=2019-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1982318, encodeId=4c67198231839, content=<a href='/topic/show?id=13b658e849' target=_blank style='color:#2F92EE;'>#Dev#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5878, encryptionId=13b658e849, topicName=Dev)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, 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  10. 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time=2019-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558522, encodeId=0ea615585228d, content=<a href='/topic/show?id=b68a586365' target=_blank style='color:#2F92EE;'>#DES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5863, encryptionId=b68a586365, topicName=DES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=432c14994935, createdName=fusion, createdTime=Thu Sep 05 14:20:00 CST 2019, time=2019-09-05, status=1, ipAttribution=)]
    2019-09-05 fusion
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