Baidu
map

Clin Cancer Res:3期试验| 阿霉素治疗对晚期软组织肉瘤患者的心脏毒性

2021-02-27 MedSci原创 MedSci原创

阿霉素治疗对晚期软组织肉瘤患者的心脏毒性

虽然新型系统性抗癌疗法不断在发展,但蒽环类药物仍然是多种癌症的一种重要的抗癌药物。不过,迄今为止,很少有前瞻性研究评估蒽环类药物对肉瘤患者的心脏毒性。

Jones等人在3期ANNOUNCE试验(NCT02451943)中评估了阿霉素对软组织肉瘤患者的心脏毒性。

受试患者为既往未采用过蒽环类药物治疗的局部晚期或转移性软组织肉瘤患者,左心室射血分数(LVEF)≥50%。患者可接受8个周期的阿霉素(75 mg/m2)治疗。心脏保护剂右雷佐生可由调查员自行决定使用。使用MedDRA记录有症状的心脏不良事件(AE),并使用CTCAE4.0进行分级。

LVEF的变化

504例患者接受了至少1个周期的阿霉素治疗(中位累积剂量为450.3 mg/m2[范围72.3-634.0])。心脏AE的中位随访时间为28周。接受阿霉素累积剂量较高的患者(38.6%患者累积剂量 <450 mg/m2,88.5%的为450-<600 mg/m2,90%的≥600 mg/m2)联合使用右雷佐生的频率更高,但不影响治疗效果。

不良反应

累积剂量<450 mg/m2、450-<600 mg/m2、≥600 mg/m2的患者的LVEF恶化率分别为40.5%(62/153)、51.6%(82/159)、56.2%(50/89),3级及以上的心功能不全发生率分别为2%、3%、1.1%。在所有剂量范围内,与治疗相关的心脏不良反应的发生率都很低。

总之,虽然本研究随访时间较短,但随访结果足以表明,在与心脏保护剂右雷佐生联合使用的情况下,阿霉素的累积剂量可以达到很高(>450 mg/m2),且心脏毒性发生率较低。

原始出处:

Jones Robin L,Wagner Andrew J,Kawai Akira et al. Prospective evaluation of doxorubicin cardiotoxicity in advanced soft tissue sarcoma patients treated in the ANNOUNCE Phase 3 randomized trial. Clin Cancer Res, 2021, 10.1158/1078-0432.CCR-20-4592

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=944402, encodeId=28999444021d, content=阿霉素治疗心脏毒性,3期实验已完成, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Mon Mar 01 12:39:24 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420469, encodeId=78f7142046972, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Mon Mar 01 07:16:39 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531336, encodeId=3f0b153133670, content=<a href='/topic/show?id=4683129675' target=_blank style='color:#2F92EE;'>#3期试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1296, encryptionId=4683129675, topicName=3期试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06eb12252541, createdName=zexyw05, createdTime=Mon Mar 01 07:16:39 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=943986, encodeId=2c5794398693, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27165136786, createdName=14669a9cm19暂无昵称, createdTime=Sat Feb 27 16:42:31 CST 2021, time=2021-02-27, status=1, ipAttribution=)]
    2021-03-01 科研科研科研

    阿霉素治疗心脏毒性,3期实验已完成

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=944402, encodeId=28999444021d, content=阿霉素治疗心脏毒性,3期实验已完成, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Mon Mar 01 12:39:24 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420469, encodeId=78f7142046972, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Mon Mar 01 07:16:39 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531336, encodeId=3f0b153133670, content=<a href='/topic/show?id=4683129675' target=_blank style='color:#2F92EE;'>#3期试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1296, encryptionId=4683129675, topicName=3期试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06eb12252541, createdName=zexyw05, createdTime=Mon Mar 01 07:16:39 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=943986, encodeId=2c5794398693, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27165136786, createdName=14669a9cm19暂无昵称, createdTime=Sat Feb 27 16:42:31 CST 2021, time=2021-02-27, status=1, ipAttribution=)]
    2021-03-01 qilu_qi
  3. [GetPortalCommentsPageByObjectIdResponse(id=944402, encodeId=28999444021d, content=阿霉素治疗心脏毒性,3期实验已完成, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Mon Mar 01 12:39:24 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420469, encodeId=78f7142046972, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Mon Mar 01 07:16:39 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531336, encodeId=3f0b153133670, content=<a href='/topic/show?id=4683129675' target=_blank style='color:#2F92EE;'>#3期试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1296, encryptionId=4683129675, topicName=3期试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06eb12252541, createdName=zexyw05, createdTime=Mon Mar 01 07:16:39 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=943986, encodeId=2c5794398693, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27165136786, createdName=14669a9cm19暂无昵称, createdTime=Sat Feb 27 16:42:31 CST 2021, time=2021-02-27, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=944402, encodeId=28999444021d, content=阿霉素治疗心脏毒性,3期实验已完成, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Mon Mar 01 12:39:24 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420469, encodeId=78f7142046972, content=<a href='/topic/show?id=2221935219e' target=_blank style='color:#2F92EE;'>#软组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93521, encryptionId=2221935219e, topicName=软组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=52913579937, createdName=qilu_qi, createdTime=Mon Mar 01 07:16:39 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531336, encodeId=3f0b153133670, content=<a href='/topic/show?id=4683129675' target=_blank style='color:#2F92EE;'>#3期试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1296, encryptionId=4683129675, topicName=3期试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06eb12252541, createdName=zexyw05, createdTime=Mon Mar 01 07:16:39 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=943986, encodeId=2c5794398693, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27165136786, createdName=14669a9cm19暂无昵称, createdTime=Sat Feb 27 16:42:31 CST 2021, time=2021-02-27, status=1, ipAttribution=)]
    2021-02-27 14669a9cm19暂无昵称

    学习

    0

相关资讯

JACC:ACEI和β受体阻滞剂能减少化疗乳腺癌患者的心脏毒性

曲妥单抗对表皮生长因子受体2(HER2)阳性的乳腺癌非常有效,但其会损伤左室收缩功能。本研究的目的旨在评估ACEI或β受体阻滞剂能否减少曲妥单抗引起的心脏毒性。本次随机双盲对照研究纳入了468名HER2阳性乳腺癌女性,平均年龄 51±10.7岁,随机分成了赖诺普利组、卡维地洛组和安慰剂组。经过2年时间的随访,安慰剂组患者的心脏毒性发生率为32%,卡维地洛组为29%,赖诺普利组为30%。在接受蒽环类

JACC:Ibrutinib药物会出现严重的心脏毒性反应

Ibrutinib药物对于严重B淋巴细胞瘤的治疗来说是一场革命,然而近期的临床试验结果显示Ibrutinib会增加患者的死亡风险,其中心源性毒性被认为是罪魁祸首。本研究的目的旨在评估Ibrutinib药物相关的心血管毒性反应(CV-ADR)。本研究发现了303例Ibrutinib药物相关性死亡,Ibrutinib与更高的室上性心律失常(SVAs)相关(ROR: 23.1; 95% cl: 21.6

JAHA:乳腺癌患者心脏毒性和心血管生物标志物

NT-proBNP和血红蛋白与接受剂量强化化疗的早期乳腺癌患者的心脏毒性反应显著相关,而高敏心脏肌钙蛋白T则不然。

Eur Heart J:抗癌治疗引起的心脏毒性分类、患病率和结局

由此可见,大多数患者在癌症治疗期间或之后出现了心肌损伤/功能障碍的客观数据。但是,严重的CTox具有很强的预后关系,发生相对较少。

这种肿瘤治疗相关心脏损伤死亡率高!阜外学者综述

免疫检查点抑制剂如针对细胞毒T淋巴细胞相关抗原4(CTLA-4)、程序性死亡受体-1(PD-1)及其配体的单克隆抗体治疗已成为越来越多肿瘤的标准治疗,越来越多的患者应用这些药物的同时出现免疫相关副反应

Hesperos的芯片可模拟药物在人体内心脏和肝脏毒性,未来可用于预测临床结果

发表在Nature Scientific Reports杂志上最新研究显示,Hesperos 公司的"human-on-a-chip"芯片装置通过模拟心脏和肝脏,可以测量两种已知的可可损害心脏的小分子药物浓度和代谢,并能够提供对人体毒性的准确数据。

Baidu
map
Baidu
map
Baidu
map