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ECC 2015：依维莫司能显著延长无功能的胃肠道和肺神经内分泌肿瘤（RADIANT-4研究）

2015-10-01 MedSci MedSci原创

ECC2015神经内分泌肿瘤
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               当地时间9月26日12:30，在ECC2015召开的第二次新闻发布会上，又有两项重要的最新研究摘要(LateBreakingAbstract)——RADIANT-4和NETTER-1研究亮相。在此对RADIANT-4研究作一简介。  &nb

       

        当地时间9月26日12:30，在ECC2015召开的第二次新闻发布会上，又有两项重要的最新研究摘要(LateBreakingAbstract)——RADIANT-4和NETTER-1研究亮相。在此对RADIANT-4研究作一简介。

        

RADIANT-4研究的主要研究者、来自美国的JamesYao教授指出，神经内分泌肿瘤(NET)是少见病、不可治愈，且目前的治疗选择很有限，尤其是在进展为晚期时。依维莫司是一种mTOR抑制剂，既往Ⅱ～Ⅲ期研究显示依维莫司对各种起源的晚期NET都有抗肿瘤活性。RADIANT-4研究作为首项评估依维莫司用于无功能的胃肠道NET和肺NET的安慰剂对照、双盲Ⅲ期临床试验，共入组302例患者，按2∶1的比例分别接受依维莫司治疗或安慰剂，治疗直至进展或出现不能耐受的毒性反应。

结果显示，研究达到了主要研究终点，依维莫司组较安慰剂组使中心评估的无进展生存(PFS)期改善达2.8倍(11个月对3.9个月，P<0.00001)，降低疾病进展风险达52%[风险比(HR)0.48]。研究者评估的PFS期有相似结果，依维莫司组有显著延长(14个月对5.5个月，HR0.39，P<0.00001)。在总生存(OS)方面，依维莫司组也显示有延长趋势，但目前仅是中期分析数据，下一次的OS分析数据有望在2016年公布。Yao教授认为，“虽然我们已知依维莫司可延缓胰腺NET的生长，但该项研究首次让我们看到依维莫司对其他部位起源的NET也有效，有望成为胰腺NET或肺NET的新治疗选择。”

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    2015-10-06 chenzhuanggui

    #肺神经#

    0

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    2016-09-11 1249898am27暂无昵称

    #内分泌肿瘤#

    0

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    2016-01-03 gwc392

    #分泌#

    0

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    2016-04-27 lily1616

    #神经内分泌#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1808830, encodeId=4d8f180883012, content=<a href='/topic/show?id=dc6a822580c' target=_blank style='color:#2F92EE;'>#肺神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82258, encryptionId=dc6a822580c, topicName=肺神经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Tue Oct 06 16:03:00 CST 2015, time=2015-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763459, encodeId=6c6a1e6345981, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Sun Sep 11 22:03:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682220, encodeId=0ac016822201a, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sun Jan 03 23:03:00 CST 2016, time=2016-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953689, encodeId=49a71953689d3, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Wed Apr 27 17:03:00 CST 2016, time=2016-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1954195, encodeId=27bc19541954f, content=<a href='/topic/show?id=3eb664e988' target=_blank style='color:#2F92EE;'>#ECC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6479, encryptionId=3eb664e988, topicName=ECC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Apr 09 11:03:00 CST 2016, time=2016-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637165, encodeId=00e8163e165eb, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Oct 29 11:03:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346194, encodeId=4db31346194d7, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Oct 03 05:03:00 CST 2015, time=2015-10-03, status=1, ipAttribution=)]
    2016-04-09 仁医06

    #ECC#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1808830, encodeId=4d8f180883012, content=<a href='/topic/show?id=dc6a822580c' target=_blank style='color:#2F92EE;'>#肺神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82258, encryptionId=dc6a822580c, topicName=肺神经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Tue Oct 06 16:03:00 CST 2015, time=2015-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763459, encodeId=6c6a1e6345981, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Sun Sep 11 22:03:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682220, encodeId=0ac016822201a, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sun Jan 03 23:03:00 CST 2016, time=2016-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953689, encodeId=49a71953689d3, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Wed Apr 27 17:03:00 CST 2016, time=2016-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1954195, encodeId=27bc19541954f, content=<a href='/topic/show?id=3eb664e988' target=_blank style='color:#2F92EE;'>#ECC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6479, encryptionId=3eb664e988, topicName=ECC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Apr 09 11:03:00 CST 2016, time=2016-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637165, encodeId=00e8163e165eb, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Oct 29 11:03:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346194, encodeId=4db31346194d7, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Oct 03 05:03:00 CST 2015, time=2015-10-03, status=1, ipAttribution=)]
    2015-10-29 ms9608593228839890

    #DIA#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1808830, encodeId=4d8f180883012, content=<a href='/topic/show?id=dc6a822580c' target=_blank style='color:#2F92EE;'>#肺神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82258, encryptionId=dc6a822580c, topicName=肺神经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Tue Oct 06 16:03:00 CST 2015, time=2015-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763459, encodeId=6c6a1e6345981, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Sun Sep 11 22:03:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682220, encodeId=0ac016822201a, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sun Jan 03 23:03:00 CST 2016, time=2016-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953689, encodeId=49a71953689d3, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Wed Apr 27 17:03:00 CST 2016, time=2016-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1954195, encodeId=27bc19541954f, content=<a href='/topic/show?id=3eb664e988' target=_blank style='color:#2F92EE;'>#ECC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6479, encryptionId=3eb664e988, topicName=ECC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Apr 09 11:03:00 CST 2016, time=2016-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637165, encodeId=00e8163e165eb, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Oct 29 11:03:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346194, encodeId=4db31346194d7, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Oct 03 05:03:00 CST 2015, time=2015-10-03, status=1, ipAttribution=)]
    2015-10-03 docwu2019

    #胃肠道#

    0

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