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CLIN CANCER RES ：miRNA-DNMT1轴与与阿扎胞苷抵抗及预测高风险骨髓增生异常综合征和低原始细胞急性髓系白血病预后有关

2017-07-03 MedSci MedSci原创

miRNADNMT1阿扎胞苷
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阿扎胞苷可以抑制包括DNMT1在内的DNA甲基转移酶，目前是治疗高风险骨髓增生异常综合征（HRMDS）或低原始细胞急性髓系白血病（AML）的标准治疗方法。CLIN CANCER RES近期发表了一篇文章，作者比较了阿扎胞苷抵抗与阿扎胞苷敏感骨髓增生异常综合征细胞的miRNA表达。在体外研究不同表达的miRNA对DNMT1表达及阿扎胞苷耐药的影响。作者还评估了75例接受阿扎胞苷治疗的HRMDS或AM

阿扎胞苷可以抑制包括DNMT1在内的DNA甲基转移酶，目前是治疗高风险骨髓增生异常综合征（HRMDS）或低原始细胞急性髓系白血病（AML）的标准治疗方法。CLIN CANCER RES近期发表了一篇文章，作者比较了阿扎胞苷抵抗与阿扎胞苷敏感骨髓增生异常综合征细胞的miRNA表达。在体外研究不同表达的miRNA对DNMT1表达及阿扎胞苷耐药的影响。作者还评估了75例接受阿扎胞苷治疗的HRMDS或AML患者治疗前骨髓样本中抗DNMT1 miRNA的表达。

研究结果表明，在DNMT1蛋白水平高的阿扎胞苷耐药的细胞中，7种miRNA受到抑制。异常的抗DNMT1 miRNA表达会降低DNMT1表达并增强阿扎胞苷敏感性，同时特异性阻断内源性抗DNMT1 miRNA可以增加DNMT1表达并诱发阿扎胞苷耐药。在接受阿扎胞苷治疗的患者中，抗DNMT1 miRNA表达下调与不良预后有关。miR-126*有最强的预后作用。miR-126*低的骨髓增生性异常综合征反应率更低且复发率更高，无进展生存及总生存更短。多因素分析表明年龄及miR-126*表达是无进展生存及总生存的独立预测因素。在15例标本中，miRNA表达水平下降与继发耐药有关。

文章最后认为，在HRMDS及AML中，抗DNMT1 miRNAs表达下调可能与阿扎胞苷耐药有关。在治疗前及治疗过程中检测miRNA表达可以预测原发及继发阿扎胞苷耐药。

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    2017-10-30 xinmeili

    #骨髓增生异常综合#

    0

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    2017-09-17 zlawrance

    #高风险#

    0

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    2018-02-22 fengyqf

    #骨髓增生#

    0

  4. 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    2018-01-13 smallant2002

    #miR#

    0

  5. 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    2018-01-06 fangcong

    #髓系白血病#

    0

  6. 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    2018-01-27 mgqwxj

    #DNMT1#

    0

  7. 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    2018-02-22 heli0118

    #骨髓增生异常#

    0

  8. 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    2017-07-05 Homburg

    #miRNA#

    0

  9. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Jul 05 08:34:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218305, encodeId=a638218305c5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Tue Jul 04 00:21:58 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-05 zhouqu_8

    #综合征#

    0

  10. 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    2017-07-04 189****7206

    学习了受益匪浅

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