Neurology：视网膜病变或可揭示多发性硬化进展
2012-12-28 Neurology CMT 银子 编译
约翰霍普金斯多发性硬化（MS）中心的研究人员近期发表在《神经杂志》上的研究表明：视网膜（眼球视网膜表面的膜）变薄或可揭示多发性硬化的进展情况。 研究人员观察到，MS复发患者比MS未复发的患者视网膜变薄的速度快42%，具体的研究结果如下：钆增强病变（炎性病变）的MS患者视
约翰霍普金斯多发性硬化（MS）中心的研究人员近期发表在《神经杂志》上的研究表明：视网膜（眼球视网膜表面的膜）变薄或可揭示多发性硬化的进展情况。
研究人员观察到，MS复发患者比MS未复发的患者视网膜变薄的速度快42%，具体的研究结果如下：钆增强病变（炎性病变）的MS患者视网膜变薄速度快54%；核磁共振显示，有新T2病变的MS患者比一般MS患者视网膜变薄的速度快36%；研究过程中视网膜变薄速度快37%，受试者的残疾程度就加重；患病5年以内的患者比患病5年以上的患者，视网膜变薄速度快43%。
Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning
Objective
To determine the effect of clinical and radiologic disease activity on the rate of thinning of the ganglion cell/inner plexiform (GCIP) layer and the retinal nerve fiber layer in patients with multiple sclerosis (MS) using optical coherence tomography (OCT).
Methods
One hundred sixty-four patients with MS and 59 healthy controls underwent spectral-domain OCT scans every 6 months for a mean follow-up period of 21.1 months. Baseline and annual contrast-enhanced brain MRIs were performed. Patients who developed optic neuritis during follow-up were excluded from analysis.
Results
Patients with the following features of disease activity during follow-up had faster rates of annualized GCIP thinning: relapses (42% faster, p = 0.007), new gadolinium-enhancing lesions (54% faster, p < 0.001), and new T2 lesions (36% faster, p = 0.02). Annual GCIP thinning was 37% faster in those with disability progression during follow-up, and 43% faster in those with disease duration <5 years vs >5 years (p = 0.003). Annual rates of GCIP thinning were highest in patients exhibiting combinations of new gadolinium-enhancing lesions, new T2 lesions, and disease duration <5 years (70% faster in patients with vs without all 3 characteristics, p < 0.001).
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#多发性#
37
#Neurol#
43
#视网膜#
29
#视网膜病变#
39