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Am J Clin Nutr:黄酮类食物并不能降低冠心病事件的发生

2016-10-30 MedSci MedSci原创

背景:黄酮类化合物是具有多种提出有益的心血管的膳食多酚类化合物,但在地理和种族多元化的美国,黄酮的摄入量与冠心病事件相关性(CHD)前瞻性研究较少。目的:用新的,扩大农业部黄酮类数据库,研究者评估不同地区的人群总黄酮和黄酮类的摄入量与CHD的发生的相关性,以及年龄、性别、种族、居住地区的修饰效应。设计:纳入REGARDS研究的受试者为16678名黑人和白人男性和女性,这是一项全国性的前瞻性队列研究

背景:黄酮类化合物是具有多种提出有益的心血管的膳食多酚类化合物,但在地理和种族多元化的美国,黄酮的摄入量与冠心病事件相关性(CHD)前瞻性研究较少。

目的:用新的,扩大农业部黄酮类数据库,研究者评估不同地区的人群总黄酮和黄酮类的摄入量与CHD的发生的相关性,以及年龄、性别、种族、居住地区的修饰效应。

设计:纳入REGARDS研究的受试者为16678名黑人和白人男性和女性,这是一项全国性的前瞻性队列研究。基线所有受试者均无冠心病,并全部完成block98食物频率问卷。美国农业部的黄酮类数据库评估黄酮类的摄入量,数据库最近进行了改进,解决熟食食品的遗失值,并调整加工过程中,黄酮类化合物的丢失。受试者自己报告CHD事件的发生,由专家确认。
采用Cox比例风险回归分析黄酮类检测作为冠心病的预测因素的HRs值。用中位数表示趋势。

结果:随访的平均值± SD为:6.0 ± 1.9年,共有589例发生了冠心病事件。
黄酮类化合物的摄入量与白人种族,运动,不吸烟,更多的教育和更高的收入相关。校正社会人口、健康行为和饮食因素,在模型中,花青素和原花青素的摄入量与冠心病事件发生呈负相关性(花青素最高五分位数与最低五分位数相比:HR 0.71年;95%CI:0.52,0.98;;原花青素:0.63;95%CI:0.47,0.84;)。总黄酮或其他黄酮类化合物的摄入量和冠心病事件没有相关性。

结论:花青素和原花青素的摄入量与冠心病的发病呈负相关。年龄,性别,种族,或居住地区没有显著的修饰效应。

原始出处:

Goetz ME, Judd SE, et al. Dietary flavonoid intake and incident coronary heart disease: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Am J Clin Nutr. 2016 Sep 21.


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    2017-03-30 fengyi821
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    2016-11-10 1dedfe95m66(暂无匿称)

    哎呀,观念大转

    0

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    2016-11-01 yhy100201
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