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Circulation:功能性三尖瓣反流提示射血分数降低的心衰患者预后不良

2019-07-17 MedSci MedSci原创

功能性三尖瓣反流(FTR)在心力衰竭中常见,其射血分数降低,主要继发于肺动脉高压。但FTR的内在临床意义尚不完全明确。本研究对Mayo诊所2003年-2011年确诊的射血分数<50%的B-C期心衰患者进行研究,采用超声对FTR分级、评估收缩期肺动脉压。排除有起搏器/除颤器、器质性瓣膜病或既往做过瓣膜手术的患者。主要评估指标是总体死亡率。共纳入13026位患者,11507位(88%)患者检查出

功能性三尖瓣反流(FTR)在心力衰竭中常见,其射血分数降低,主要继发于肺动脉高压。但FTR的内在临床意义尚不完全明确。

本研究对Mayo诊所2003年-2011年确诊的射血分数<50%的B-C期心衰患者进行研究,采用超声对FTR分级、评估收缩期肺动脉压。排除有起搏器/除颤器、器质性瓣膜病或既往做过瓣膜手术的患者。主要评估指标是总体死亡率。

共纳入13026位患者,11507位(88%)患者检查出FTR(33%可忽略、32% 轻度、17% 中度、6% 重度),年龄68±14岁,35% 为女性,射血分数位36±10%,肺动脉收缩压位41±14mmHg,20%的患者伴有房颤

与FTR独立相关的协变量有肺动脉收缩压升高、年老、女性、射血分数降低、二尖瓣返流和房颤。FTR与呼吸困难、肾功能受损和心排血量降低独立相关。对于长期预后,相比三尖瓣反流,FTR程度越高,死亡率越高。功能性FTR越严重,5年存活率越低,极轻、轻、中、重度FTR的5年存活率分别是68±1%、58±2%、45±2%和34±4%。

对于射血分数降低的心衰患者,FTR常见,并与肺动脉高压、房颤和严重的心衰表现独立相关。FTR越严重,患者的长期预后越差,且与患者的基础特征无关。

原始出处:

Giovanni Benfari, et al. Excess Mortality Associated With Functional Tricuspid Regurgitation Complicating Heart Failure With Reduced Ejection Fraction. https://doi.org/10.1161/CIRCULATIONAHA.118.038946Circulation. 2019;140:196–206

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    2019-07-27 1467b185m41暂无昵称

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  5. 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  6. 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  7. 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encodeId=e0e315e847048, content=<a href='/topic/show?id=a1021962883' target=_blank style='color:#2F92EE;'>#三尖瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19628, encryptionId=a1021962883, topicName=三尖瓣)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7cb16409801, createdName=124985dbm11(暂无昵称), createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1692060, encodeId=839f1692060fe, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Sat Mar 28 07:33:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915510, encodeId=69bd191551023, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Mon Sep 16 05:33:00 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370371, encodeId=535d3e037175, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ed15142159, createdName=1467b185m41暂无昵称, createdTime=Sat Jul 27 23:43:40 CST 2019, time=2019-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373449, encodeId=a11c13e3449b4, content=<a href='/topic/show?id=2fd051939ab' target=_blank style='color:#2F92EE;'>#心衰患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51939, encryptionId=2fd051939ab, topicName=心衰患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407834, encodeId=fa13140e8341f, content=<a href='/topic/show?id=f73019633bf' target=_blank style='color:#2F92EE;'>#三尖瓣反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19633, encryptionId=f73019633bf, topicName=三尖瓣反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec6c2728397, createdName=meichuangyi, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449252, encodeId=53e914492520e, content=<a href='/topic/show?id=2ff746814f0' target=_blank style='color:#2F92EE;'>#射血分数降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46814, encryptionId=2ff746814f0, topicName=射血分数降低)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50105466425, createdName=lmm399, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488358, encodeId=e0af148835888, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493346, encodeId=b9941493346ab, content=<a href='/topic/show?id=ff1a4681ee0' target=_blank style='color:#2F92EE;'>#射血分数降低的心衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46817, encryptionId=ff1a4681ee0, topicName=射血分数降低的心衰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74979029791, createdName=fusion, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571651, encodeId=8a4915e1651bd, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578470, encodeId=e0e315e847048, content=<a href='/topic/show?id=a1021962883' target=_blank style='color:#2F92EE;'>#三尖瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19628, encryptionId=a1021962883, topicName=三尖瓣)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7cb16409801, createdName=124985dbm11(暂无昵称), createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1692060, encodeId=839f1692060fe, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Sat Mar 28 07:33:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915510, encodeId=69bd191551023, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Mon Sep 16 05:33:00 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370371, encodeId=535d3e037175, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ed15142159, createdName=1467b185m41暂无昵称, createdTime=Sat Jul 27 23:43:40 CST 2019, time=2019-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373449, encodeId=a11c13e3449b4, content=<a href='/topic/show?id=2fd051939ab' target=_blank style='color:#2F92EE;'>#心衰患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51939, encryptionId=2fd051939ab, topicName=心衰患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407834, encodeId=fa13140e8341f, content=<a href='/topic/show?id=f73019633bf' target=_blank style='color:#2F92EE;'>#三尖瓣反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19633, encryptionId=f73019633bf, topicName=三尖瓣反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec6c2728397, createdName=meichuangyi, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449252, encodeId=53e914492520e, content=<a href='/topic/show?id=2ff746814f0' target=_blank style='color:#2F92EE;'>#射血分数降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46814, encryptionId=2ff746814f0, topicName=射血分数降低)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50105466425, createdName=lmm399, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488358, encodeId=e0af148835888, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493346, encodeId=b9941493346ab, content=<a href='/topic/show?id=ff1a4681ee0' target=_blank style='color:#2F92EE;'>#射血分数降低的心衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46817, encryptionId=ff1a4681ee0, topicName=射血分数降低的心衰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74979029791, createdName=fusion, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571651, encodeId=8a4915e1651bd, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578470, encodeId=e0e315e847048, content=<a href='/topic/show?id=a1021962883' target=_blank style='color:#2F92EE;'>#三尖瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19628, encryptionId=a1021962883, topicName=三尖瓣)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7cb16409801, createdName=124985dbm11(暂无昵称), createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=)]
    2019-07-19 feifers
  10. [GetPortalCommentsPageByObjectIdResponse(id=1692060, encodeId=839f1692060fe, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Sat Mar 28 07:33:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915510, encodeId=69bd191551023, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, 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encodeId=e0e315e847048, content=<a href='/topic/show?id=a1021962883' target=_blank style='color:#2F92EE;'>#三尖瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19628, encryptionId=a1021962883, topicName=三尖瓣)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7cb16409801, createdName=124985dbm11(暂无昵称), createdTime=Fri Jul 19 13:33:00 CST 2019, time=2019-07-19, status=1, ipAttribution=)]
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