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Thorax:囊性纤维化患儿和健康婴儿的呼吸道病毒分析!

2017-08-13 xing.T MedSci原创

由此可见,在CF患者中病毒检测并不常见,病毒检测时呼吸道症状发生率低于健康对照组。这可能是由于不同的因素,如局部上皮特性和免疫机制的相互作用所致。

囊性纤维化(CF)患儿急性病毒性呼吸道感染是引起疾病恶化的常见原因。然而,婴儿期病毒感染对疾病恶化的作用还不太清楚,尽管婴儿早期被认为是CF疾病发展的关键时期。近日,胸部疾病领域权威杂志Thorax上发表了一篇研究文章,研究人员前瞻性地评估了CF患儿和健康对照者在婴儿期一岁期间有症状和无症状的病毒检测。在一项前瞻性队列研究中,研究人员从瑞士婴儿肺囊性纤维化发展队列中纳入了31例CF患者和32例从巴塞尔伯尔尼婴儿肺发育队列中纳入了未经选择的、健康的婴儿,并随访至婴儿一岁。研究人员通过每周电话访谈评估呼吸道症状。研究人员采用实时七双重PCR通过每两周鼻拭子来分析10种不同的病毒和非典型细菌(CF=561,对照=712)。研究人员发现CF患者和健康对照组婴儿表现出同样数量的拭子阳性病毒(平均为42% vs. 44%;比值比为0.91,95%可信区间为0.66至1.26,P=0.6)。在CF患者中病毒阳性拭子不常伴有呼吸道症状(17% vs. 23%;比值比为0.64,95%可信区间为0.43至0.95,P=0.026)。这一发现在有症状的鼻病毒检测患者中十分明显(7% vs. 11%;比值比

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1675845, encodeId=274016e5845db, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40375, encryptionId=7395403e580, topicName=囊性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=926927300775, createdName=wolongzxh, createdTime=Wed May 16 19:20:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282420, encodeId=e7b21282420da, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Tue Aug 15 07:20:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233217, encodeId=5f7123321e56, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 13 18:39:06 CST 2017, time=2017-08-13, status=1, ipAttribution=)]
    2018-05-16 wolongzxh
  2. [GetPortalCommentsPageByObjectIdResponse(id=1675845, encodeId=274016e5845db, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40375, encryptionId=7395403e580, topicName=囊性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=926927300775, createdName=wolongzxh, createdTime=Wed May 16 19:20:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282420, encodeId=e7b21282420da, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Tue Aug 15 07:20:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233217, encodeId=5f7123321e56, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 13 18:39:06 CST 2017, time=2017-08-13, status=1, ipAttribution=)]
    2017-08-15 zhmscau
  3. [GetPortalCommentsPageByObjectIdResponse(id=1675845, encodeId=274016e5845db, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40375, encryptionId=7395403e580, topicName=囊性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=926927300775, createdName=wolongzxh, createdTime=Wed May 16 19:20:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282420, encodeId=e7b21282420da, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Tue Aug 15 07:20:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233217, encodeId=5f7123321e56, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Aug 13 18:39:06 CST 2017, time=2017-08-13, status=1, ipAttribution=)]
    2017-08-13 李东泽

    这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。

    0

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