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JAMA:3期随机试验| 司马鲁肽的减肥效果!

2021-03-01 MedSci原创 MedSci原创

司马鲁肽会成为官方减肥药物吗?

减肥可以改善超重或肥胖者的心脏代谢危险因素。强化生活方式干预和药物治疗是最有效的非侵入性减肥方法。

本研究旨在比较每周皮下注射一次司马鲁肽(semaglutide) 2.4 mg vs 安慰剂作为强化行为疗法和低热量饮食的补充体重管理对超重或肥胖者的减肥效果。

这是一项随机、双盲、平行分组、为期68周的多中心3a期研究,于2018年8月-2020年4月招募无糖尿病的、超重(BMI≥27)加上至少1个共患病或肥胖(BMI≥30)的成年人(n=611)。受试者被随机(2:1)分至司马鲁肽组(n=407)或安慰剂组(n=204),前8周均结合低卡路里饮食,68周期间进行强化行为治疗(即,30次咨询治疗)。共同的主要终点是在68周时体重的百分比变化和体重下降≥5%;次要终点包括体重较基线相比减少10%或15%。

在611名随机受试者中(495名女性[81.0%],平均年龄 46岁、体重 105.8 kg、BMI 38.0)中,567名(92.8%)完成了试验,505名(82.7%)在试验结束时仍在接受治疗。

在第68周时,司马鲁肽组和安慰剂组的估计平均体重变化分别为-16.0%和-5.7%(差异为-10.3%[95%CI,-12.0~-8.6%];P<0.001)。服用司马鲁肽的受试者比服用安慰剂的受试者至少减去了5%的基线体重(分别为86.6%和47.6%;P<0.001)。与安慰剂组相比,司马鲁肽组体重减轻至少10%或15%的受试者比例更高(分别为75.3% vs 27.0%和55.8% vs 13.2%;P<0.001)。

服用司马鲁肽的患者胃肠道不良事件发生率(82.8%)高于安慰剂(63.2%)。司马鲁肽组有3.4%的受试者因胃肠道不良事件停止治疗,而安慰剂组无受试者因不良反应停止治疗。

总之,在超重或肥胖的成年人中,与安慰剂相比,每周皮下注射一次司马鲁肽作为强化行为治疗和低卡路里饮食的辅助措施,有助于受试者在68周时获得显著更大的体重减轻。此外,还需要进一步的研究来评估司马鲁肽减肥作用的持久性。

原始出处:

Wadden Thomas A,Bailey Timothy S,Billings Liana K et al. Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial. JAMA, 2021, 10.1001/jama.2021.1831

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    2021-03-18 ms2000000440286978

    在哪里能买到啊?

    0

  4. 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    2021-03-07 肥狐jolie

    期待更多数据

    0

  5. 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    2021-03-06 ms5000001187302846

    真的很有效,身边有人用过,瘦了39斤

    0

  6. 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    2021-03-03 鼠叔叔啦啦

    减肥

    0

  9. 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    2021-03-02 科研科研科研

    司马鲁肽的减肥效果3期试验完成

    0

  10. 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channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38731, encryptionId=cf0638e31e4, topicName=司马鲁肽)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Mar 03 07:52:40 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512172, encodeId=659b15121e20c, content=<a href='/topic/show?id=cfd19846697' target=_blank style='color:#2F92EE;'>#随机试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98466, encryptionId=cfd19846697, topicName=随机试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c3710444656, createdName=124985dbm09(暂无昵称), createdTime=Wed Mar 03 07:52:40 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944988, encodeId=a3b494498890, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e6d5462230, createdName=鼠叔叔啦啦, createdTime=Wed Mar 03 05:29:38 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944847, encodeId=453d94484e0b, content=司马鲁肽的减肥效果3期试验完成, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Tue Mar 02 18:05:28 CST 2021, time=2021-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944516, encodeId=4ec294451661, content=效果可以啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210301/28e81c1eda64491ea0507710c5173138/2e20c197213f4d2bb2c03374b04301e6.jpg, createdBy=bfa51746861, createdName=Angela, createdTime=Mon Mar 01 17:24:32 CST 2021, time=2021-03-01, status=1, ipAttribution=)]
    2021-03-01 Angela

    效果可以啊

    1

    展开1条回复

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