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NEJM:常年咀嚼烟叶导致口腔鳞状细胞癌的发生

2017-09-22 MedSci MedSci原创

患者,女,54岁,因口腔肿胀疼痛一年就诊于口腔诊所。 患者有经常咀嚼散烟叶的习惯,将烟叶放在颌骨和舌之间,每天多达五次,长达十多年。口内检查显示下颌左内侧病变区为不规则硬化病变,尺寸最大为3厘米(图A)。组织切片活检显示结缔组织中具有变色、多形性细胞和“角化珠”(图B)的浸润性鳞状细胞癌。计算机断层扫描和正电子发射断层扫描显示没有骨或淋巴结受累。 鳞状细胞癌是口腔最常见的肿瘤类型。患将

患者,女,54岁,因口腔肿胀疼痛一年就诊于口腔诊所。

患者有经常咀嚼散烟叶的习惯,将烟叶放在颌骨和舌之间,每天多达五次,长达十多年。口内检查显示下颌左内侧病变区为不规则硬化病变,尺寸最大为3厘米(图A)。组织切片活检显示结缔组织中具有变色、多形性细胞和“角化珠”(图B)的浸润性鳞状细胞癌。计算机断层扫描和正电子发射断层扫描显示没有骨或淋巴结受累。



鳞状细胞癌是口腔最常见的肿瘤类型。患将癌组织整块切除,并进行节段性下颌切除术,使用血管化游离腓骨瓣进行骨移植及选择性颈清扫术。病理分析显示未累及骨或淋巴结,无肿瘤边缘。

建议病人停止使用烟草制品。治疗两年后,未复发。

原始出处:


Tanay V. Chaubal,Renjeet A. Bapat. Squamous-Cell Carcinoma of the Mouth. N Engl J Med 2017; 377:1188September 21, 2017DOI: 10.1056/NEJMicm1701886.

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    2018-03-03 Boyinsh
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    2017-09-22 大爰

    学习了谢谢分享!!

    0

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    2017-09-22 清风拂面

    很好的文章.学习了

    0

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