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Neurology:叶酸补充可以减少中风的危险

2017-04-11 zhangfan MedSci原创

他汀类药物使用率低的高血压患者,低剂量的叶酸补充对中风的预防效果最佳

研究人员近日基于相关最新临床试验结果,研究叶酸补充在无叶酸补充地区的卒中预防疗效。

研究采用相对危险度(RR)评价叶酸的影响,使用固定效应模型估计中风的风险。

结果如下:总的来说,补充叶酸可使中风风险降低11%(22项临床研究,n=82723;RR=0.89,95%,CI 0.84-0.96);相比于高叶酸补充区域(7项临床研究, n = 14,655; 北美, 1.05, 0.90-1.23),低叶酸补充区域(2项临床研究, n = 24020; 亚洲, 0.78, 0.67-0.90)的效果更显着;相比于进行叶酸补充患者(7项临床研究, n = 14655; 1.05, 0.90-1.23),没有叶酸补充的患者(11 项研究, n = 49957; 0.85; 0.77-0.94)效果更显着。对没有叶酸补充患者试验的进一步分层分析中,使用低剂量叶酸(≤0.8 mg: 0.78, 0.69-0.88)或低基线维生素B12水平(<384 pg/mL: 0.78, 0.68-0.89)的患者益处更大。在相应的对照组中,无明显中风仿制效果

研究表明叶酸补充可以减少中风的危险,特别无叶酸补充的区域。对于他汀类药物使用率低的高血压患者,低剂量的叶酸补充效果最为显着。

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    2017-08-07 yinhl1978
  2. [GetPortalCommentsPageByObjectIdResponse(id=1999871, encodeId=845d19998e1ff, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Aug 07 14:00:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188280, encodeId=62191882804d, content=研究叶酸补充在无叶酸补充地区的卒中预防疗效。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Mon Apr 17 18:27:45 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188252, encodeId=b6171882521e, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Mon Apr 17 15:32:15 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188249, encodeId=00ad18824931, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Mon Apr 17 14:49:31 CST 2017, time=2017-04-17, status=1, ipAttribution=)]
    2017-04-17 Albert Wu

    研究叶酸补充在无叶酸补充地区的卒中预防疗效。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1999871, encodeId=845d19998e1ff, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Aug 07 14:00:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188280, encodeId=62191882804d, content=研究叶酸补充在无叶酸补充地区的卒中预防疗效。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Mon Apr 17 18:27:45 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188252, encodeId=b6171882521e, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Mon Apr 17 15:32:15 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188249, encodeId=00ad18824931, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Mon Apr 17 14:49:31 CST 2017, time=2017-04-17, status=1, ipAttribution=)]
    2017-04-17 1dd8aa01m06(暂无匿称)

    学习了很好的内容

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1999871, encodeId=845d19998e1ff, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Aug 07 14:00:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188280, encodeId=62191882804d, content=研究叶酸补充在无叶酸补充地区的卒中预防疗效。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Mon Apr 17 18:27:45 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188252, encodeId=b6171882521e, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Mon Apr 17 15:32:15 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188249, encodeId=00ad18824931, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Mon Apr 17 14:49:31 CST 2017, time=2017-04-17, status=1, ipAttribution=)]
    2017-04-17 186****0580(小山羊)

    学习了谢谢了。

    0

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