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阿尔茨海默症协会国际会议:轻度认知障碍令死亡风险加倍

2012-07-18 陈蓉 :eurekalert

      叶史瓦大学阿尔伯特?爱因斯坦医学院和Montefiore 医学中心的研究人员发现,罹患一种轻度认知障碍(MCI)的人的死亡风险是认知功能正常的人的两倍。那些有痴呆症的人的死亡风险为认知功能正常者的三倍。这些发现于本星期在温哥华召开的阿尔茨海默症协会国际会议上进行了报告。   遗忘型MCI是一种疾病,患有这种病况的人的记忆问题比那些有着

      叶史瓦大学阿尔伯特•爱因斯坦医学院和Montefiore 医学中心的研究人员发现,罹患一种轻度认知障碍(MCI)的人的死亡风险是认知功能正常的人的两倍。那些有痴呆症的人的死亡风险为认知功能正常者的三倍。这些发现于本星期在温哥华召开的阿尔茨海默症协会国际会议上进行了报告。

  遗忘型MCI是一种疾病,患有这种病况的人的记忆问题比那些有着相同年龄和教育的正常人要更为严重,但是不会严重到影响病人的日常生活。(另外一种MCI形式是非遗忘型MCI,它的特征是思维技能受损而不是记忆受损,例如他们在策划和组织上会有麻烦,或判断力不佳。)据阿尔茨海默症协会披露,长期的研究提示,年龄65岁及以上者中有10-20%的人可能患有MCI。

  爱因斯坦医学院的研究人员对参加爱因斯坦老年化研究的733人进行了研究。这些研究参与者年龄至少70岁,并居住在布朗克斯。在研究开始的时候,他们每个人都做了一个基线认知功能评估并至少有过一次年度随访。他们还接受了APOE-4基因变异体的测试,该变异体与阿尔茨海默症的风险增加有关联。对参与者的追踪平均为5年(最高至16年)。

  研究人员发现,患有遗忘型MCI的参与者有2倍以上(2.17倍)的死亡风险。非遗忘型MCI看来不会增加其死亡风险。患有痴呆症的参与者的死亡风险比那些认知功能正常者要高出3倍以上(3.26倍)。研究人员还发现,具有APOE-4基因变异体、较多合并症及严重的抑郁症也与较高的死亡风险有关。

  本研究的资深作者及爱因斯坦老年化研究负责人Richard Lipton说:“尽管对MCI、痴呆症或阿尔茨海默症没有治疗的方法,但这些发现支持了早期发现的裨益并支持了对认知损害的监控以延长生命的做法。

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