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J Cell Mol Med:EPC衍生的外泌体通过LncRNA-MALAT1促进破骨细胞生成

2019-04-28 不详 网络

骨修复涉及通过破骨细胞生成的骨吸收和内皮祖细胞(EPC)对新血管形成和骨生成的刺激。然而,EPCs在破骨细胞生成中的作用尚不清楚。在本研究中,我们使用免疫荧光,蛋白质印迹,RT-PCR和Transwell测定评估了EPC衍生的外泌体对体外原代小鼠骨髓来源的巨噬细胞(BMM)的迁移和破骨细胞分化的影响。我们还评估了EPC衍生的外泌体对体内小鼠骨折模型中移植的BMM的归巢和破骨细胞分化的影响。结果显示

骨修复涉及通过破骨细胞生成的骨吸收和内皮祖细胞(EPC)对新血管形成和骨生成的刺激。然而,EPCs在破骨细胞生成中的作用尚不清楚。

在本研究中,我们使用免疫荧光,蛋白质印迹,RT-PCR和Transwell测定评估了EPC衍生的外泌体对体外原代小鼠骨髓来源的巨噬细胞(BMM)的迁移和破骨细胞分化的影响。我们还评估了EPC衍生的外泌体对体内小鼠骨折模型中移植的BMM的归巢和破骨细胞分化的影响。

结果显示,与BMM共培养的EPCs将外泌体分泌到培养基中,与EPC相比,外泌体具有更高的LncRNA-MALAT1表达水平。我们证实LncRNA-MALAT1直接与miR-124结合以负面控制miR-124活性。此外,miR-124的过表达可逆转由EPC衍生的外泌体诱导的BMM的迁移和破骨细胞分化。双荧光素酶报告基因测定表明整联蛋白ITGB1是miR-124的靶标。与单独用BMM处理的小鼠相比,用EPC衍生的外泌体-BMM共移植处理的小鼠在骨折部位表现出增加的新血管形成并且增强了骨折愈合。

总之,我们的结果表明,EPC衍生的外泌体可以通过LncRNA-MALAT1增强破骨细胞前体的募集和分化来促进骨修复。

原始出处:

Cui Y, Fu S, et al,, EPC-derived exosomes promote osteoclastogenesis through LncRNA-MALAT1. J Cell Mol Med. 2019 Apr 25. doi: 10.1111/jcmm.14228.

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    2019-07-05 维他命
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    2019-04-30 xzw113
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