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J Periodontal Res:肽涂料抑制牙种植体表面牙龈卟啉单胞菌的黏附

2020-04-16 lishiting MedSci原创

非手术以及手术的干预方式是治疗种植体周围炎的方法;然而,这些治疗方法的疗效并不令人十分满意。其主要原因为种植体表面粗糙和螺纹的设计导致其表面牙菌斑的附着。近期,学者们研发了一种应用于种植体表面基于肽的

非手术以及手术的干预方式是治疗种植体周围炎的方法;然而,这些治疗方法的疗效并不令人十分满意。其主要原因为种植体表面粗糙和螺纹的设计导致其表面牙菌斑的附着。近期,学者们研发了一种应用于种植体表面基于肽的涂料,它能够抵制大肠杆菌的黏附并且促进宿主细胞的附着。因此,这篇研究的目的是为了评估基于肽的涂料是否能够抑制与牙周炎和种植体周围炎相关的一种关键人致病菌-牙龈卟啉单胞菌的黏附。

研究通过肽包被空圆盘表面以获得一层唾液薄膜,并通过抗人IG G, A和M以及抗纤维蛋白进行验证。分别通过绿和红荧光染料示踪早期克隆、小韦荣球菌和远源链球菌以及晚期克隆和牙龈卟啉单胞菌,随后接种于圆盘上。通过荧光强度半定量分析细菌的黏附。

结果显示,唾液粘膜平坦的分布在圆盘上,在伴随肽涂层与否的情况下其平均厚度为3.84 µm。唾液粘膜表面存在多种属的牙生物被膜。与对照、未施加肽涂层组相比,肽涂层大约减少了25%小韦荣球菌和远源链球菌的黏附,减少了50%牙龈卟啉单胞菌的黏附。

结论:这种全新的基于肽的涂层能够抑制牙龈卟啉单胞菌的黏附。它可能具有阻止种植体周围炎进展的潜力。

原始出处:

Dongdong Fang, Sivan Yuran, et al. A Peptide Coating Preventing the Attachment of Porphyromonas Gingivalis on the Surfaces of Dental Implants. J Periodontal Res., 2020 Feb 24. doi: 10.1111/jre.12737.

 

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    2020-11-15 huangdf
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    2021-03-26 feather89
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