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Cancer Cell:NCOA5基因缺陷可能导致肝细胞癌、葡萄糖耐受不良

2013-12-12 佚名 生物通

来自密歇根州立大学和南方医科大学的研究人员发现,一种遗传缺陷可以触发男性形成最常见的一种肝癌类型和糖尿病。这项研究在线发表于12月9日的《癌细胞》(Cancer Cell)杂志上。 南方医科大学南方医院罗荣城(Rongcheng Luo)教授和密歇根州立大学医学院生理学副教授肖华(Hua Xiao,音译)是这篇论文的共同通讯作者。罗荣城教授长期从事临床非常肿瘤学医教研

来自密歇根州立大学和南方医科大学的研究人员发现,一种遗传缺陷可以触发男性形成最常见的一种肝癌类型和糖尿病。这项研究在线发表于12月9日的《癌细胞》(Cancer Cell)杂志上。

南方医科大学南方医院罗荣城(Rongcheng Luo)教授和密歇根州立大学医学院生理学副教授肖华(Hua Xiao,音译)是这篇论文的共同通讯作者。罗荣城教授长期从事临床非常肿瘤学医教研工作,在肿瘤综合诊疗方面有较深造诣,是我国肿瘤多学科综合关系治疗和循证医学模式的积极倡导者和开拓者。在国内外刊物上发表学术论文150余篇。

新研究揭示,当雄性小鼠的NCOA5基因发生改变至缺陷水平时,会发生一种自发性反应,生成的细胞可导致肝细胞癌——这种肝癌类型男性的发病率是女性的2-4倍。

研究结果还表明,在癌症形成前出现了葡萄糖耐受不良,这一提高人类2型糖尿病风险的前驱症状。与之相反,研究表明雌性小鼠不会形成这些疾病。

肖华说:“实质上,这提供了证据表明,男性对这种特殊的肝癌类型和糖尿病具有遗传易感性。我们观察到94%的雄性小鼠形成了肝癌,100%的这些小鼠形成了葡萄糖耐受不良。”

肖华认为,男女之间这种截然不同的结果或许与两性之间的激素水平差异有关。“因为雌激素有可能是通过NCOA5基因发挥功能,而以往的研究证实雌激素对防止两种疾病在一定程度上起保护作用,因而使得女性的风险降低。由此男性只生成较少量的雌激素,可能促成了他们的易感性。”

2型糖尿病作为一种常见的风险因子,一直以来与肝癌广泛相关。鉴于全球糖尿病发病率不断升高,且当前针对肝细胞癌的治疗有限,这项研究开启了通向新治疗方案的大门。

肖华说:“就这一点而言,尚不知道这种遗传缺陷是否能够逆转,还需要进一步的研究调查。但如果能够通过药物治疗等以某种方式改变它,就有可能大大提高男性抵御这些疾病的机会。”

原文出处:

Shenglan Gao, Aimin Li, Feiye Liu, Fengsheng Chen, Mark Williams, Chengliang Zhang, Zakiya Kelley, Chin-Lee Wu, Rongcheng Luo, Hua Xiao.NCOA5 Haploinsufficiency Results in Glucose Intolerance and Subsequent Hepatocellular Carcinoma.Cancer Cell, Volume 24, Issue 6, 725-737, 9 December 2013.【原文下载】


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    2014-01-10 xjy02
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    2014-03-08 维他命
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    2014-08-12 circumcision
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