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Diabetes:GLP-1与胃饥饿素协同调节葡萄糖耐受

2018-08-20 MedSci MedSci原创

新出现的证据表明胃饥饿素对预防饥饿诱导的低血糖具有重要意义。可效应可能是通过抑制葡萄糖刺激的胰岛素分泌以及降低胰岛素敏感性介导的。但是,在进食过程中服用饥饿素也可刺激释放胰高血糖素样肽(GLP-1)——在营养配置过程中发挥重要作用的一种肠促胰岛素。Laura C. Page等研究人员开展研究对饥饿素与GLP-1对混合营养餐后的唐耐受参数的相互作用进行评估。其共招募了15位健康成年人(男女都有)。1

新出现的证据表明饥饿素对预防饥饿诱导的低血糖具有重要意义。可效应可能是通过抑制葡萄糖刺激的胰岛素分泌以及降低胰岛素敏感性介导的。但是,在进食过程中服用饥饿素也可刺激释放胰高血糖素样肽(GLP-1)——在营养配置过程中发挥重要作用的一种肠促胰岛素。

Laura C. Page等研究人员开展研究对饥饿素与GLP-1对混合营养餐后的唐耐受参数的相互作用进行评估。其共招募了15位健康成年人(男女都有)。15位受试者被随机分至四组,每组受试者在进食一份标准餐的同时额外输注一份盐水、饥饿素、GLP-1受体拮抗剂毒晰外泌肽-[9-39](Ex9)或饥饿素+Ex9。

与既往研究相似,输注饥饿素可引起葡萄糖耐受不良,而Ex9的该效应最小。但是,饥饿素与Ex9一起输注时所引起的餐后血糖要高于两者单用时所引起的,该效应与β细胞功能受损和糖清除减少相关。

本研究结果表明在喂食状态下,GLP-1刺激可缓解饥饿素对葡萄糖耐受的部分影响。胃肠激素之间的这种新型相互作用提示体内存在一种平衡进食和空腹状态下胰岛素分泌和葡萄糖处理的系统。


原始出处:

Laura C. Page, et al. Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans. Diabetes  2018 Jul;  db180451. https://doi.org/10.2337/db18-0451

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1902114, encodeId=ace119021140f, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon Apr 22 02:16:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760777, encodeId=39b01e6077756, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Mar 22 21:16:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993837, encodeId=1d6b199383e26, content=<a href='/topic/show?id=3c0a8342075' target=_blank style='color:#2F92EE;'>#胃饥饿素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83420, encryptionId=3c0a8342075, topicName=胃饥饿素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Tue Feb 26 01:16:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638726, encodeId=97061638e264a, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Jun 28 10:16:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422726, encodeId=2e631422e26e4, content=<a href='/topic/show?id=54fa80e701' target=_blank style='color:#2F92EE;'>#GLP-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8077, encryptionId=54fa80e701, topicName=GLP-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f23732777, createdName=yibei, createdTime=Wed Aug 22 11:16:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454750, encodeId=27961454e5061, content=<a href='/topic/show?id=d370101185d7' target=_blank style='color:#2F92EE;'>#饥饿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101185, encryptionId=d370101185d7, topicName=饥饿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c9a5593064, createdName=guojianrong, createdTime=Wed Aug 22 11:16:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339782, encodeId=5d17339e82da, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Mon Aug 20 21:19:13 CST 2018, time=2018-08-20, status=1, ipAttribution=)]
    2018-08-22 yibei
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1902114, encodeId=ace119021140f, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon Apr 22 02:16:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760777, encodeId=39b01e6077756, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Mar 22 21:16:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993837, encodeId=1d6b199383e26, content=<a href='/topic/show?id=3c0a8342075' target=_blank style='color:#2F92EE;'>#胃饥饿素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83420, encryptionId=3c0a8342075, topicName=胃饥饿素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Tue Feb 26 01:16:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638726, encodeId=97061638e264a, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Jun 28 10:16:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422726, encodeId=2e631422e26e4, content=<a href='/topic/show?id=54fa80e701' target=_blank style='color:#2F92EE;'>#GLP-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8077, encryptionId=54fa80e701, topicName=GLP-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f23732777, createdName=yibei, createdTime=Wed Aug 22 11:16:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454750, encodeId=27961454e5061, content=<a href='/topic/show?id=d370101185d7' target=_blank style='color:#2F92EE;'>#饥饿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101185, encryptionId=d370101185d7, topicName=饥饿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c9a5593064, createdName=guojianrong, createdTime=Wed Aug 22 11:16:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339782, encodeId=5d17339e82da, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Mon Aug 20 21:19:13 CST 2018, time=2018-08-20, status=1, ipAttribution=)]
    2018-08-20 orangesking

    0

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