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Neurology:非糖尿病女性低空腹血清胰岛素与痴呆

2018-07-12 xing.T MedSci原创

之前的一项研究报道在老年男性的5年随访中,空腹胰岛素与痴呆之间存在U形关联。该研究结果证实了女性人群的非线性关联,低胰岛素值的高风险不是由于临床前痴呆或胰岛素分泌受损。这种情况表明痴呆发生可能存在新的途径,其与参与糖尿病的代谢途径有所不同。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,考虑到糖尿病的发病率,研究人员在34岁以上女性的代表性人群中调查了空腹血清胰岛素与痴呆之间的前瞻性关联。

在1968年,研究人员获取了1212名38至60岁的非糖尿病女性的血清胰岛素和血糖空腹数值,通过Cox比例风险回归评估痴呆风险,调整了胰岛素、葡萄糖和其他协变量,并在第二个模型中,评估了糖尿病发生病例。糖尿病被认为是与痴呆进行比较的第三个终点。

34年来,研究人员观察到了142例痴呆事件。与中间三分位数相比,较低三分位胰岛素水平显示出痴呆风险增加(风险比[HR]为2.34,95%可信区间[CI]为1.52-3.58),但胰岛素水平处于较高三分位数的受试者痴呆风险没有增加(HR为1.28,95%CI为0.81-2.03)。这些与痴呆症的关联也见于没有糖尿病合并症的患者。相反,较高但不是较低水平的胰岛素可预测糖尿病发生(115例)(分别有HR为1.70,95%CI为1.08-2.68和HR为0.76,95%CI为0.43-1.37)。

之前的一项研究报道在老年男性的5年随访中,空腹胰岛素与痴呆之间存在U形关联。该研究结果证实了女性人群的非线性关联,低胰岛素值的高风险不是由于临床前痴呆或胰岛素分泌受损。这种情况表明痴呆发生可能存在新的途径,其与参与糖尿病的代谢途径有所不同。

原始出处:

Kirsten Mehlig,et al. Low fasting serum insulin and dementia in nondiabetic women followed for 34 years.neurology.2018. https://doi.org/10.1212/WNL.0000000000005911

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    2018-12-18 yinhl1978
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    2018-11-06 baoya
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1991175, encodeId=a5d319911e503, content=<a href='/topic/show?id=b29c99594dd' target=_blank style='color:#2F92EE;'>#非糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99594, encryptionId=b29c99594dd, topicName=非糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sun May 12 19:14:00 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000497, encodeId=4452200049ead, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Dec 18 08:14:00 CST 2018, time=2018-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749989, encodeId=30bd1e4998997, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Tue Nov 06 18:14:00 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819602, encodeId=a2531819602c8, content=<a href='/topic/show?id=6f3a9959636' target=_blank style='color:#2F92EE;'>#非糖尿病女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99596, encryptionId=6f3a9959636, topicName=非糖尿病女性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Aug 19 11:14:00 CST 2018, time=2018-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332975, encodeId=34613329e5b6, content=非糖尿病女性低空腹血糖的治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jul 20 21:24:52 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331253, encodeId=031e3312537f, content=学习下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jul 13 09:00:31 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041706, encodeId=71411041e06a9, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jul 12 13:14:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048482, encodeId=628f10484829d, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jul 12 13:14:00 CST 2018, time=2018-07-12, status=1, ipAttribution=)]
    2018-07-20 jyzxjiangqin

    非糖尿病女性低空腹血糖的治疗。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1991175, encodeId=a5d319911e503, content=<a href='/topic/show?id=b29c99594dd' target=_blank style='color:#2F92EE;'>#非糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99594, encryptionId=b29c99594dd, topicName=非糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sun May 12 19:14:00 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000497, encodeId=4452200049ead, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Dec 18 08:14:00 CST 2018, time=2018-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749989, encodeId=30bd1e4998997, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Tue Nov 06 18:14:00 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819602, encodeId=a2531819602c8, content=<a href='/topic/show?id=6f3a9959636' target=_blank style='color:#2F92EE;'>#非糖尿病女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99596, encryptionId=6f3a9959636, topicName=非糖尿病女性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Aug 19 11:14:00 CST 2018, time=2018-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332975, encodeId=34613329e5b6, content=非糖尿病女性低空腹血糖的治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jul 20 21:24:52 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331253, encodeId=031e3312537f, content=学习下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jul 13 09:00:31 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041706, encodeId=71411041e06a9, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jul 12 13:14:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048482, encodeId=628f10484829d, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jul 12 13:14:00 CST 2018, time=2018-07-12, status=1, ipAttribution=)]
    2018-07-13 kafei

    学习下谢谢

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1991175, encodeId=a5d319911e503, content=<a href='/topic/show?id=b29c99594dd' target=_blank style='color:#2F92EE;'>#非糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99594, encryptionId=b29c99594dd, topicName=非糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sun May 12 19:14:00 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000497, encodeId=4452200049ead, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Dec 18 08:14:00 CST 2018, time=2018-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749989, encodeId=30bd1e4998997, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Tue Nov 06 18:14:00 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819602, encodeId=a2531819602c8, content=<a href='/topic/show?id=6f3a9959636' target=_blank style='color:#2F92EE;'>#非糖尿病女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99596, encryptionId=6f3a9959636, topicName=非糖尿病女性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Aug 19 11:14:00 CST 2018, time=2018-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332975, encodeId=34613329e5b6, content=非糖尿病女性低空腹血糖的治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Jul 20 21:24:52 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331253, encodeId=031e3312537f, content=学习下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Jul 13 09:00:31 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041706, encodeId=71411041e06a9, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jul 12 13:14:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048482, encodeId=628f10484829d, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Jul 12 13:14:00 CST 2018, time=2018-07-12, status=1, ipAttribution=)]
    2018-07-12 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2018-07-12 junJUN

    老年人痴呆何药可用??

    0

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