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BMC Ophthalmol:中国高血压成人患者的血清尿酸浓度与高血压性视网膜病变有关

2017-06-05 cuiguizhong MedSci原创

北京大学第一医院眼科的杨柳教授近期在BMC Ophthalmol发表了他们的一项研究,指出中国高血压成人患者的血清尿酸浓度与高血压性视网膜病变有关。

北京大学第一医院眼科的杨柳教授近期在BMC Ophthalmol发表了他们的一项研究,指出中国高血压成人患者的血清尿酸浓度与高血压性视网膜病变有关。

他们进行的调查包括12,966例高血压患者,一组中国脑卒中一级预防研究(CSPPT),是随机的多中心临床试验。在发表的论文中,他们主要探讨了高血压患者体内血清尿酸(SUA)浓度与高血压性视网膜病变之间的相关性。



实验的具体方法是,通过非散瞳眼底摄影来诊断是否患有高血压性视网膜病变,并根据Keith-Wagener-Barker(KWB)系统进行分类。通过统计分析来确定SUA水平与高血压性视网膜病变患病率和严重程度的相关性。

他们最终发现,9848例(75.95%)受试者被诊断为高血压性视网膜病变,具有以下视网膜病变分级:1级:58.80%,2级:14.81%,3-4级:2.34%。 SUA水平与高血压性视网膜病变患病率存在显着相关性。高血压性视网膜病变患者的SUA水平显着高于未患有高血压性视网膜病变的人。尿酸最高四分位的患者与尿酸最低四分位患者(OR = 1.21,95%CI:1.05-1.40,P = 0.008)相比,高血压性视网膜病变的优势比为1.21。与非高尿酸症的群体相比,高尿酸血症群体的高血压性视网膜病变的优势比为1.18(OR = 1.18,95%CI:1.05?1.33,P = 0.004)。尿酸浓度每增加1mg / dl,高血压性视网膜病变的几率显着高出6%(OR = 1.06,95%CI:1.02-1.10,P = 0.002)。

杨柳的团队最终得出结论,患者队列中高血压病患者的高血压性视网膜病变患病率高(75.95%),而且SUA浓度与高血压性视网膜病变存在显着相关性。这项研究推进了人们对高血压性视网膜病变的致病机制的理解。

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    2017-06-07 zutt
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西班牙圣地亚哥德孔波斯特拉大学(CIMUS)眼科的González F团队近日在Invest Ophthalmol Vis Sci杂志上发表了他们近期的一项研究工作。文章指出,在研究玻璃体清除随时间的变化过程中,正电子发射断层扫描(PET)可以作为非侵入性的手段来研究玻璃体内注射的药代动力学特征。

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