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Stroke:中年糖尿病患者,低HRV与卒中发生风险增加相关

2016-06-02 phylis 译 MedSci原创

背景:低心率变异(HRV)是心脏植物神经功能紊乱的标志,与全因死亡率和心血管死亡率升高相关。研究者在社区人群中研究了心率变异性降低和卒中之间的关联。方法:社区动脉粥样硬化风险(ARIC)研究使用2分钟心电图测量12 550个中年人基线(1987-1989)的HRV。采用RR间期SD计算HRV指标(SDNN),所有正常RR间期均值(meanNN),连续RR间期方差的均方根(RMSSD)、低频(LF)

背景:低心率变异(HRV)是心脏植物神经功能紊乱的标志,与全因死亡率和心血管死亡率升高相关。研究者在社区人群中研究了心率变异性降低和卒中之间的关联。

方法:社区动脉粥样硬化风险(ARIC)研究使用2分钟心电图测量12 550个中年人基线(1987-1989)的HRV。采用RR间期SD计算HRV指标(SDNN),所有正常RR间期均值(meanNN),连续RR间期方差的均方根(RMSSD)、低频(LF)和高频(HF),和LF / HF比值。所有的HRV数值分为五份。2011年确定卒中事件的发生。根据是否有糖尿病进行分层,将最低HRV作为对照,采用Cox回归模型评估危险比(HR)。

结果:随访的中位数为22年,816(6.5%)例受试者发生了卒中。校正协变量后,HRV和卒中风险之间没有相关性。与最高在分层分析中,最低HRV与卒中风险升高相关。在分层分析中,仅在糖尿病患者中发现,与最高五分位数的SDNN(HR,2,95%CI,1.1-4.0)、RMSSD(HR,1.7;95%CI,0.9-3.2)、LF(HR,1.5;95%CI,0.8-3.0),和HF(HR,1.7;95%CI,0.9-3.0),最低五分位数的HRV与较高的卒中风险相关。

结论:在糖尿病患者中,中年人低HRV与卒中发生风险增加相关。

原始出处:

Fyfe-Johnson AL, Muller CJ, et al. Heart Rate Variability and Incident Stroke: The Atherosclerosis Risk in Communities Study. Stroke. 2016 Jun.


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  1. [GetPortalCommentsPageByObjectIdResponse(id=132229, encodeId=68af13222934, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 09:01:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127534, encodeId=86b812e53442, content=了解新知识,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Thu Sep 15 14:22:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473986, encodeId=ee5814e398611, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Jun 04 10:47:00 CST 2016, time=2016-06-04, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=132229, encodeId=68af13222934, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 09:01:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127534, encodeId=86b812e53442, content=了解新知识,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Thu Sep 15 14:22:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473986, encodeId=ee5814e398611, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Jun 04 10:47:00 CST 2016, time=2016-06-04, status=1, ipAttribution=)]
    2016-09-15 舒心和人

    了解新知识,感谢分享

    0

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