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Cell Metab:“自制力本能”更有利于减肥的成功

2018-10-20 佚名 生物探索

10月18日,《细胞代谢》杂志发表了一项最新的研究成果:高层次的大脑功能在减肥中起着重要作用:脑部刺激的主要对象通常是被称为背外侧前额皮质的区域,该区域与自我控制饮食有关,所以提高自我控制能力更有利于减肥成功。



加拿大蒙特利尔神经研究所和医院(Montreal Neurological Institute and Hospital)的研究人员发现,人类对自身体重的控制很大程度上取决于大脑自我控制和自我调节的区域。大脑外侧前额皮质区域有能力考虑到长期信息,比如想要健康的愿望,以控制眼前的欲望。

“瘦素和饥饿素这两种激素会在减肥时触发人体进食。先前的研究证实,当体重减轻时,这些激素水平会迅速变化”,蒙特利尔神经研究所和医院的资深研究作者Alain Dagher说, “每个减肥的人都看得到瘦素和饥饿素的变化,只是有些人,出于我们不知道的原因,能够在这种信号面前保持自我调节。”

为了评估这些荷尔蒙和自我控制在减肥中的作用,蒙特利尔神经研究人员对24名减肥诊所的受试者进行了研究。在开始标准的1200千卡/天减肥饮食之前,所有参与者都接受了一项大脑功能磁共振成像研究(fMRI),该研究评估了包括与自我调节相关的外侧前额叶皮质和涉及动机、欲望和价值的腹内侧前额叶皮质在内的区域。

接下来,研究人员向受试者展示了一些开胃食物的图片以及一些风景图片。研究人员比较了受试者在基线、1个月和3个月时大脑活动对食物图片的反应,特别是高热量食物图片的反应。

研究人员注意到,在1个月和3个月的时候,来自前额叶前部皮层的信号会下降,而在那些减肥成功的人中,这种信号下降的幅度最大。此外,在整个研究过程中,参与自我控制的侧前额皮质信号增强。


图片来源: CC0 Public Domain

Dagher说:“在fMRI中,自我控制区域增加了活动,价值区域减少了活动。变化的量可以预测成功的减肥效果。”虽然所有的参与者都减肥了,但是那些减肥效果最好的参与者的功能磁共振成像水平表明他们有更好的自我控制能力。而且,在为期3个月的研究结束时,激素胃饥饿素和瘦素开始恢复到基线水平,这表明一个新的设定值已经达到。

这些结果表明,那些在减肥方面取得最大成功的人,在与自我控制相关的外侧前额皮质区域表现出更多的活动。所以提高自我控制能力更有利于减肥成功。

原始出处;

Selin Neseliler, Wen Hu, Kevin Larcher, et.al. Neurocognitive and Hormonal Correlates of Voluntary Weight Loss in Humans. Cell Metabolism
Available online 18 October 2018

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    2018-12-11 一闲
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    2019-01-15 guojianrong
  3. [GetPortalCommentsPageByObjectIdResponse(id=1896399, encodeId=1d711896399af, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue Dec 11 14:42:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887950, encodeId=7787188e950ee, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jan 15 18:42:00 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961212, encodeId=b0431961212d2, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Jun 30 00:42:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870940, encodeId=6b3218e094036, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Oct 24 09:42:00 CST 2018, time=2018-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350146, encodeId=250435014623, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Oct 22 10:15:25 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048244, encodeId=d669104824491, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Oct 20 13:42:00 CST 2018, time=2018-10-20, status=1, ipAttribution=)]
    2019-06-30 维他命
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    2018-10-22 kafei

    学习学习谢谢

    0

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    2018-10-20 CHANGE

    什么时候有懒人用的减肥神药?

    0

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