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柳叶刀:专家质疑肥胖手术的价值

2015-02-15 孟秋君 医学论坛网

治疗肥胖的金科玉律“少吃多动”耳熟能详,但一组肥胖学专家在《柳叶刀·糖尿病学》上发表观点,对治疗肥胖的有效程度提出质疑。他们认为,肥胖是一种由生物原因引起的慢性疾病,无法依靠单纯的饮食和锻炼治愈。 很多人可在几个月的时间内减重,但80%–95%的人最终恢复了原来的体重。这一短暂减重成功归因于生物系统减少了热量的摄入。在现代阶段性肥胖患者中,这些生物调控系统支持热量的吸收并将其存储为脂肪,以

治疗肥胖的金科玉律“少吃多动”耳熟能详,但一组肥胖学专家在《柳叶刀·糖尿病学》上发表观点,对治疗肥胖的有效程度提出质疑。他们认为,肥胖是一种由生物原因引起的慢性疾病,无法依靠单纯的饮食和锻炼治愈。

很多人可在几个月的时间内减重,但80%–95%的人最终恢复了原来的体重。这一短暂减重成功归因于生物系统减少了热量的摄入。在现代阶段性肥胖患者中,这些生物调控系统支持热量的吸收并将其存储为脂肪,以此保护机体。故而单纯依靠生活方式的改变无法做到脂肪燃烧,达到减重目的。研究作者如是说。

“尽管生活方式的修正可令肥胖患者的体重下降一段时间,但对于慢性肥胖患者,体重变成了生物系统最直接的体现。”来自美国纽约西奈山伊坎医学院的儿科和精神病学助理教授、本文的主要作者克里斯托弗·欧彻博士解释道,“因此,当前少食多运动的建议对大多数肥胖患者来讲并非那么管用。”

此外,他指出,当前的建议表明生物适应可长期维持,甚至在曾经实现了健康体重的肥胖患者中亦是如此。“几乎不存在个体从肥胖中真正恢复;他们更像是经历着肥胖减轻期。不同的个体因年龄、性别和体重的区别而有着不同的生物特性。”

作者论证,如果长期体重减少,至少有些生物因素需要被重置。然而,基于当前干预的生物特性受限于抗肥胖药物、减重手术以及腹内迷走神经阻滞,这些都不可能从根本上纠正削弱减重手段的诸多生物因素。迄今为止,仅有Roux-en-Y胃旁路术(一种常见的治疗极特殊肥胖的手术)被证实可扭转控制食欲的荷尔蒙及大脑对食物的控制。研究作者说,这也许能够解释腹腔镜胃绕道手术是唯一能够达到令个体长期、持续减重治疗的目的。

根据欧彻博士的观点,“一些临床医生意识不到个体实现减重的原因。肥胖应该作为一种慢性且长期的疾病,它由生物和行为等多种原因引起,需要一系列的医学干预(包括生物基础干预,诸如药物治疗或手术,以及生活方式的改变)。”他补充道,“忽视这些生物学特性、持续依赖生活方式的改变,将导致肥胖治疗的有效性大打折扣,并造成每年数以百计的个体过早死亡。”


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    2015-10-17 saikp
  2. [GetPortalCommentsPageByObjectIdResponse(id=1735058, encodeId=fdbb1e3505882, content=<a href='/topic/show?id=9aa5923e176' target=_blank style='color:#2F92EE;'>#质疑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92371, encryptionId=9aa5923e176, topicName=质疑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3033872914, createdName=saikp, createdTime=Sat Oct 17 20:33:00 CST 2015, time=2015-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16683, encodeId=fa7f16683c8, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:18:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16252, encodeId=3d151625295, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 01:02:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15991, encodeId=9b7915991cf, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:22:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15992, encodeId=0d6a159920a, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:22:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15958, encodeId=e9d0159581c, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:15:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15656, encodeId=209e1565651, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 13:26:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-02-22 orthoW

    不错的文章,学习了

    0

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    2015-02-17 chinayinhan

    已阅

    0

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    2015-02-16 Johnny1989

    0

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    2015-02-16 Johnny1989

    已阅

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1735058, encodeId=fdbb1e3505882, content=<a href='/topic/show?id=9aa5923e176' target=_blank style='color:#2F92EE;'>#质疑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92371, encryptionId=9aa5923e176, topicName=质疑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3033872914, createdName=saikp, createdTime=Sat Oct 17 20:33:00 CST 2015, time=2015-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16683, encodeId=fa7f16683c8, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:18:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16252, encodeId=3d151625295, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 01:02:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15991, encodeId=9b7915991cf, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:22:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15992, encodeId=0d6a159920a, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:22:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15958, encodeId=e9d0159581c, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:15:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15656, encodeId=209e1565651, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 13:26:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-02-16 Johnny1989

    谢谢分享!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1735058, encodeId=fdbb1e3505882, content=<a href='/topic/show?id=9aa5923e176' target=_blank style='color:#2F92EE;'>#质疑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92371, encryptionId=9aa5923e176, topicName=质疑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3033872914, createdName=saikp, createdTime=Sat Oct 17 20:33:00 CST 2015, time=2015-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16683, encodeId=fa7f16683c8, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:18:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16252, encodeId=3d151625295, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 01:02:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15991, encodeId=9b7915991cf, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:22:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15992, encodeId=0d6a159920a, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:22:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15958, encodeId=e9d0159581c, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:15:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15656, encodeId=209e1565651, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 13:26:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-02-16 windmilL1989

    0

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