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Clin Cancer Res:镭223治疗增加转移性前列腺癌骨微环境中胞外囊泡的免疫检查点表达

2021-04-09 AlexYang MedSci原创

镭-223可延长一部分骨转移性前列腺癌(PCa)男性的生存期。然而,目前还没有监测镭-223治疗反应和耐药性的标志物。外泌体是细胞间通信的媒介,也许能够反映骨微环境对Radium-223治疗的反应。

镭-223可延长一部分骨转移性前列腺癌(PCa)男性的生存期。然而,目前还没有监测镭-223治疗反应和耐药性的标志物。外泌体是细胞间通信的媒介,也许能够反映骨微环境对Radium-223治疗的反应

最近,有研究人员进行了外泌体的分子谱分析,并比较了有利和不利总体生存患者的分子谱

研究人员在他们的临床前模型(MDA-PCa-118b肿瘤,TRAMP-C2/BMP4 PCa)和25名接受Radium-223治疗的患者的血浆中进行了外泌体转录组分析。研究人员利用临床前模型阐释了来自肿瘤和肿瘤相关骨微环境(bTME)的基因在Radium-223治疗后,在外泌体中不同程度地富集。小鼠转录组分析显示骨相关和DNA损伤修复-相关途径发生变化。研究人员在接受镭-223治疗的患者血浆外泌体中也观察到类似的发现。此外,外泌体转录物检测到免疫抑制性(如PD-L1),其与Radium-223治疗的生存期缩短有关。用Radium-223和免疫检查点疗法(ICT)联合治疗Myc-CaP小鼠模型表明,联合治疗比单药治疗有更大的疗效。

镭-223治疗患者的外泌体PD-L1表达增加

最后,研究人员指出,这些临床和共同临床分析表明,血浆外泌体的RNA谱分析可用于监测bTME对治疗的反应,ICT可用于提高Radium-223的疗效

原始出处:

Ioulia Vardaki , Paul Corn , Emanuela Gentile et al. Radium 223 treatment increase immune checkpoint expression in extracellular vesicles from the metastatic prostate cancer bone microenvironment. Clin Cancer Res. Mar 2021

 

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    2021-04-11 hywen7331
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1340557, encodeId=c03f134055e9d, content=<a href='/topic/show?id=dd1a29055c8' target=_blank style='color:#2F92EE;'>#免疫检查点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29055, encryptionId=dd1a29055c8, topicName=免疫检查点)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Sun Apr 11 08:14:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386742, encodeId=ff941386e426e, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sun Apr 11 08:14:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395557, encodeId=674d139555e9e, content=<a href='/topic/show?id=7bbf93405a5' target=_blank style='color:#2F92EE;'>#转移性前列腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93405, encryptionId=7bbf93405a5, topicName=转移性前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Sun Apr 11 08:14:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568646, encodeId=314b15686466b, content=<a href='/topic/show?id=2708968506f' target=_blank style='color:#2F92EE;'>#镭223#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96850, encryptionId=2708968506f, topicName=镭223)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=121015405421, createdName=hywen7331, createdTime=Sun Apr 11 08:14:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599855, encodeId=e2f7159985571, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Sun Apr 11 08:14:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040993, encodeId=9f1d1040993fe, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Apr 09 20:14:23 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955542, encodeId=a57b955542df, content=阅读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Fri Apr 09 18:21:14 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955539, encodeId=bf859555396e, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Apr 09 18:11:52 CST 2021, time=2021-04-09, status=1, ipAttribution=)]
    2021-04-09 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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    2021-04-09 ms3000000449926787

    阅读了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1340557, encodeId=c03f134055e9d, content=<a href='/topic/show?id=dd1a29055c8' target=_blank style='color:#2F92EE;'>#免疫检查点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29055, encryptionId=dd1a29055c8, topicName=免疫检查点)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Sun Apr 11 08:14:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386742, encodeId=ff941386e426e, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sun Apr 11 08:14:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395557, encodeId=674d139555e9e, content=<a href='/topic/show?id=7bbf93405a5' target=_blank style='color:#2F92EE;'>#转移性前列腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93405, encryptionId=7bbf93405a5, topicName=转移性前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Sun Apr 11 08:14:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568646, encodeId=314b15686466b, content=<a href='/topic/show?id=2708968506f' target=_blank style='color:#2F92EE;'>#镭223#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96850, encryptionId=2708968506f, topicName=镭223)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=121015405421, createdName=hywen7331, createdTime=Sun Apr 11 08:14:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599855, encodeId=e2f7159985571, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Sun Apr 11 08:14:23 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040993, encodeId=9f1d1040993fe, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Apr 09 20:14:23 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955542, encodeId=a57b955542df, content=阅读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Fri Apr 09 18:21:14 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955539, encodeId=bf859555396e, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Apr 09 18:11:52 CST 2021, time=2021-04-09, status=1, ipAttribution=)]
    2021-04-09 jyzxjiangqin

    好文章!

    0

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