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JAMA Intern Med:30年随访证实6个月以上母乳喂养即可大幅降低母亲糖尿病风险

2018-01-17 zhangfan MedSci原创

研究通过纵向生化证据证实,母乳喂养可大大降低母亲的糖尿病风险,持续6个月以上的母乳喂养即可获得最大的糖尿病风险降低收益

在老年妇女中,仅以糖尿病自我报告为基础,延长哺乳期会降低母亲的糖尿病风险,但其结论可能受到多种不可控风险因素的干扰。近日,研究人员通过产前、后生化检测,探讨哺乳与糖尿病的关系,并对妊娠前心脏代谢指标、妊娠期糖尿病(GD)及生活方式对结果的影响进行分析。

研究在美国多个医疗中心开展,随访30年,1238名18-30岁的,基线无糖尿病女性参与。参与者报告期哺乳时间,并在随访期间进行7次糖尿病筛查。哺乳期长短分为:无哺乳、0-6个月、6-12个月以及超过12个月。研究的主要终点为每1000随访年糖尿病发病以及相关风险,结果对生化、社会人口统计、生殖危险因素、家族糖尿病史、生活方式以及随访期间体重变化进行调整。

研究参与者平均年龄24.2岁,其中黑人女性615人。在27598个随访年中共发生了182起糖尿病事件,每1000随访年,总的糖尿病发病6.6例(95% CI, 5.6-7.6),GD以及非GD女性的糖尿病发病分别为18.0(95% CI,13.3-22.8)和5.1 (95% CI,4.2-6.0)。研究发现,母乳喂养与糖尿病发病呈强负相关,程度与母乳喂养时间相关:相比于未进行母乳喂养的女性,母乳喂养0-6个月的女性其调整后的糖尿病风险为0.75(95% CI, 0.51-1.09);母乳喂养6-12个月为0.52 (95% CI, 0.31-0.87);12个月以上为0.53(0.29-0.98),其结果不受种族和GD的影响。

研究通过纵向生化证据证实,母乳喂养可大大降低母亲的糖尿病风险,持续6个月以上的母乳喂养即可获得最大的糖尿病风险降低收益。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1665048, encodeId=59f7166504849, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Mon Nov 05 09:37:00 CST 2018, time=2018-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280241, encodeId=57c428024108, content=母乳喂养的好处., beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Jan 20 06:58:30 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299581, encodeId=d1df1299581e5, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Fri Jan 19 01:37:00 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608451, encodeId=69b91608451b8, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Fri Jan 19 01:37:00 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279569, encodeId=4d542e9569b2, content=遵循自然法则就是获益最大的选择, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/31/a88428e95e462b5a95499ced50b4325e.jpg, createdBy=60182225250, createdName=15121100f4m, createdTime=Thu Jan 18 06:19:46 CST 2018, time=2018-01-18, status=1, ipAttribution=)]
    2018-01-20 jyzxjiangqin

    母乳喂养的好处.

    0

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    2018-01-19 villahu
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    2018-01-19 医者仁心
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    2018-01-18 15121100f4m

    遵循自然法则就是获益最大的选择

    0

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