Baidu
map

AJG:糖尿病的个人病史与结肠癌的发生与大肠癌家族史一样重要

2020-07-03 MedSci原创 MedSci原创

糖尿病(DM)和大肠癌(CRC)具有一些相似的危险因素,包括生活方式和代谢紊乱。本项研究旨在探究有关CRC风险(尤其是早发性CRC)与DM的关联。

背景及目的:

糖尿病(DM)和大肠癌(CRC)具有一些相似的危险因素,包括生活方式和代谢紊乱。本项研究旨在探究有关CRC风险(尤其是早发性CRC)与DM的关联。

 

方法:

研究人员使用一项瑞典的全国性队列研究的家庭癌症数据集,进行数据分析,包括1931年以后出生的所有个体及其父母(12614256个人; 559375糖尿病患者; 162226 CRC患者)。对所有合格患者均进行了统计学分析。

 

结果:

结果显示50岁之前的DM诊断与50岁之前的CRC风险增加1.9倍相关(95%CI:1.6–2.3),而该年龄/之后年龄的CRC风险则为1.3倍(95%CI:1.2–1.4)。具有CRC家族史的患者在50岁之前进行DM诊断与50岁之前患CRC的风险是6.9倍(95%CI:4.1-12),而50岁之前或之后患CRC的风险是1.9倍(95%CI:1.4–2.5)。糖尿病患者在50岁之前有终生发生CRC的风险(0.4%,95%CI:0.3%–0.4%)。

 

讨论:

本项研究的数据表明DM与CRC风险增加相关,其程度接近于CRC家族史。DM和CRC家族史与CRC风险增加的关联在年轻人中最为明显。这些发现值得对糖尿病患者,特别是2型糖尿病患者的CRC筛查的危害,益处和成本效益进行进一步研究。

原始出处:

Ali Khan. Et al. Personal History of Diabetes as Important as Family History of Colorectal Cancer for Risk of Colorectal Cancer. The American Journal of Gastroenterology.2020.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1067952, encodeId=d74e106e952e3, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Sun Nov 07 22:47:57 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057311, encodeId=a297205e31161, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Thu Sep 03 18:14:20 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479811, encodeId=debf14e9811c6, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Sun Jul 05 00:14:20 CST 2020, time=2020-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043198, encodeId=c3a51043198a3, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 03 12:14:20 CST 2020, time=2020-07-03, status=1, ipAttribution=)]
    2021-11-07 1482963am12暂无昵称

    学习了,谢谢

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1067952, encodeId=d74e106e952e3, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Sun Nov 07 22:47:57 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057311, encodeId=a297205e31161, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Thu Sep 03 18:14:20 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479811, encodeId=debf14e9811c6, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Sun Jul 05 00:14:20 CST 2020, time=2020-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043198, encodeId=c3a51043198a3, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 03 12:14:20 CST 2020, time=2020-07-03, status=1, ipAttribution=)]
    2020-09-03 minzju5052
  3. [GetPortalCommentsPageByObjectIdResponse(id=1067952, encodeId=d74e106e952e3, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Sun Nov 07 22:47:57 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057311, encodeId=a297205e31161, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Thu Sep 03 18:14:20 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479811, encodeId=debf14e9811c6, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Sun Jul 05 00:14:20 CST 2020, time=2020-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043198, encodeId=c3a51043198a3, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 03 12:14:20 CST 2020, time=2020-07-03, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1067952, encodeId=d74e106e952e3, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Sun Nov 07 22:47:57 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057311, encodeId=a297205e31161, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Thu Sep 03 18:14:20 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479811, encodeId=debf14e9811c6, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Sun Jul 05 00:14:20 CST 2020, time=2020-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043198, encodeId=c3a51043198a3, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 03 12:14:20 CST 2020, time=2020-07-03, status=1, ipAttribution=)]
    2020-07-03 misszhang

    谢谢MedSci提供最新的资讯

    0

相关资讯

Braz J Phys Ther:孕期运动可预防孕产妇体重增长过快和妊娠糖尿病

妊娠期体重增长过快与妊娠期的一些不良事件和病症有关。本研究旨在考察整个孕期运动计划对孕产妇体重增加和妊娠糖尿病发病率的影响。

Semin Arthritis Rheu:2型糖尿病会增加肌肉骨骼疼痛的风险吗?

2型糖尿病患者更有可能报告肩/颈、膝关节或髋部的肌肉骨骼疼痛。此外,2型糖尿病患者,尤其是女性,更容易出现颈/肩痛。

Nat Genet:迄今规模很大的基因研究!揭秘2型糖尿病相关的新型遗传变异

2型糖尿病是最常见的糖尿病类型,该病由多种病因引起,导致体内胰岛素分泌不足或者人体不能有效利用胰岛素,从而出现血糖水平持续升高,进而危害心脏、肾脏、眼睛等器官。近日,一项迄今为止在同类研究中最大规模的

Diabetes Care:"神药"二甲双胍可促进肠道将血糖排到粪便中

二甲双胍治疗与肠腔内空间[18F]FDG积累增加有关,表明这种药物促进了葡萄糖从血液循环进入粪便的运输。

糖尿病出现了脚溃烂,用什么方法治疗效果好?

糖尿病患者之所以会出现脚溃烂是因为糖尿病患者的下肢血管和周围神经病变及感染三种因素共同作用下才发生在足部的一种溃烂坏疽现象。

J Periodontol:睡眠与重度牙周炎之间相关性的研究

不良的睡眠行为似乎会通过代谢失调和免疫抑制而对健康产生不利影响。睡眠障碍与糖尿病,心血管疾病和某些癌症密切相关。

Baidu
map
Baidu
map
Baidu
map