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JAMA Ophthalmol:极早产可降低儿童视杆锥功能

2017-06-30 zhangfan MedSci原创

与足月出生的儿童相比,极重度早产儿童的杆功能和锥体功能均降低,但视网膜病变与一般早产儿无相关性,这表明极早产可能是视网膜功能障碍的主要诱因

早产儿对杆状和视锥细胞功能的影响研究尚不充分。研究人员通过全视野视网膜电图(FFERG)比较了早产儿与足月儿之间的视网膜功能差异。

研究从2010年7月1日到2014年1月15日开展,月龄<27周的早产儿和足月儿参与,在参与儿童6.5岁时进行双眼FFERG测试,使用DTL电极和视网膜电图(ERG),30 Hz的3.0 cd/s/m2的单闪光,闪光强度为0.009,0.17,3.0以及12.0 cd/s/m2。主要终点是FFERG分析以及胎龄与早视网膜病变之间的关系。

研究对52名早产儿(19名女孩、33名男孩,检查时的平均年龄6.6岁)以及45名足月儿(22名女孩、23名男孩,检查时的平均年龄6.6岁)进行FFERG成像。相比于足月儿,早产儿的组合杆、锥响应(暗适应ERG的a波3.0 cd/s/m2: 平均差异, -48.9 μV [95% CI,-80.0--17.9 μV]; P=0.003; 暗适应ERG的a波12.0 cd/s/m2: 平均差异, -55.7 μV [95% CI,-92.5--18.8 μV];P=0.004)以及孤立锥响应(30Hz闪烁光ERG: 平均差异, -12.1 μV [95% CI,-22.5 - -1.6 μV]; P=0.03)振幅低。早产儿组的杆、锥响应隐式时间(暗适应ERG的a波12.0 cd/s/m2)延长(平均差异, 1.2 毫秒 [95% CI, 0.3-2.0 毫秒]; P=0.01),同时隔离锥反应(30Hz闪烁光ERG: 平均差异, 1.2毫秒[95% CI,0.5-1.8 毫秒]; P<0.001)延长。胎龄与全视野视网膜电图以及视网膜病变无相关性。

与足月出生的儿童相比,极重度早产儿童的杆功能和锥体功能均降低,但视网膜病变与一般早产儿无相关性,这表明极早产可能是视网膜功能障碍的主要诱因。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1541220, encodeId=daf21541220e3, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Sun Jul 02 05:53:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217536, encodeId=4aa921e536dd, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Jul 01 22:31:36 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217103, encodeId=b1c921e10371, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdDM6bDRvRy9LKfO8ia4GwNGt3Ueq5JR97QQCQhBViaxE2XtljmmLNh2ID4wJxbib1gTv4O0eiauaZcBU/0, createdBy=77742061279, createdName=1381edfeefm, createdTime=Fri Jun 30 15:02:25 CST 2017, time=2017-06-30, status=1, ipAttribution=)]
    2017-07-01 changjiu

    学习了,谢谢

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1541220, encodeId=daf21541220e3, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Sun Jul 02 05:53:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217536, encodeId=4aa921e536dd, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Jul 01 22:31:36 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217103, encodeId=b1c921e10371, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdDM6bDRvRy9LKfO8ia4GwNGt3Ueq5JR97QQCQhBViaxE2XtljmmLNh2ID4wJxbib1gTv4O0eiauaZcBU/0, createdBy=77742061279, createdName=1381edfeefm, createdTime=Fri Jun 30 15:02:25 CST 2017, time=2017-06-30, status=1, ipAttribution=)]
    2017-06-30 1381edfeefm

    不错,学习了

    0

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