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分子影像为肿瘤诊断与治疗提供新技术

2017-07-24 沈春蕾 中国科学报

近日,中科院自动化所分子影像重点实验室与中国人民解放军总医院(301医院)介入超声科合作,在分子影像应用于胰腺癌的介入光热治疗,以及应用于肝癌的分子标志物生物学机制研究两大领域,取得了显着的临床科研成果。相关研究进展分别发表于医学研究领域和生物材料领域的顶级期刊,成为实验室与临床医院医工交叉合作取得突破的典型范例。实验室主任田捷介绍道:“胰腺癌是一种恶性程度极高的消化道肿瘤,其手术切除率低,治疗方

近日,中科院自动化所分子影像重点实验室与中国人民解放军总医院(301医院)介入超声科合作,在分子影像应用于胰腺癌的介入光热治疗,以及应用于肝癌的分子标志物生物学机制研究两大领域,取得了显着的临床科研成果。相关研究进展分别发表于医学研究领域和生物材料领域的顶级期刊,成为实验室与临床医院医工交叉合作取得突破的典型范例。

实验室主任田捷介绍道:“胰腺癌是一种恶性程度极高的消化道肿瘤,其手术切除率低,治疗方案(化疗、放疗等)疗效都欠佳,因此临床上需要寻找更好的治疗方案。光热疗法(PTT)作为新兴治疗方式,已经引起人们极大的关注。”

然而,这种治疗方式存在光穿透性差,无法达到深部肿瘤的问题。为了解决这一问题,自动化所团队与合作团队开展了一种可以局部介入式光热治疗(IPTT)的研究。

实验结果表明,与临床上常用的125I放射性治疗相比,IPTT疗法的平均存活率提高25%,同时抑制了胰腺肿瘤的转移。“这种介入式光热疗法为胰腺癌的治疗提供新方法和新策略。”田捷说。

肝细胞癌(HCC)全球发病率高,大部分患者确诊时即为中晚期,无法手术切除,因此肝癌的早期诊断成为肝癌治疗的关键。然而,不足1 cm的肝细胞癌缺乏特征性影像学表现,无特征性分子标记物使得肝癌无法早期准确检测。因此,特异性标记物对于肝癌的早期诊断、延长生存具有重要的临床意义。

为解决这一难题,团队对GPC-3靶点进行深入研究,主要针对GPC-3靶点开展机理性探索,探究HCC细胞内多种生长因子及Wnt信号通路的调控方式,研究肝细胞癌的发生机制以及GPC-3的转运原理,并针对GPC-3靶点用于分子成像及靶向治疗进行展望,团队认为具有HCC治疗的广阔远景,有望用于临床转化。

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    2017-08-03 李东泽

    很好,不错,以后会多学习

    0

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    2017-07-26 李东泽

    很好,不错,以后会多学习

    0

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    2017-07-26 lqvr
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    2017-07-25 hfuym10906

    学习了学习了学习了学习了学习了

    0

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