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Heart:心脏生物标志物预测房颤急诊患者的死亡率

2018-11-11 xing.T MedSci原创

由此可见,NT-proBNP和hs-TnT水平升高与急诊症状性房颤患者的中期死亡率增加独立相关。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在评估血清脑钠尿肽前体N末端(NT-proBNP)和高敏感肌钙蛋白T(hs-TnT)水平对急诊症状性房颤(AF)患者中期死亡率的预测价值。

该研究为非介入性队列/随访研究,纳入了2012年至2016年间由于症状性房颤而向三级大学医院急诊科连续就诊的患者。多变量Cox比例风险回归模型用于评估血清NT-proBNP和hs-TnT不同五分位数水平每100名患者每年(pry)的死亡率和风险。

该研究的1754名患者(年龄为68(IQR为58-75)岁,女性为1199人(44%),CHA2DS2-VASc为3(IQR为1-4))共记录了2574次发作。在排除不完整的数据集之后,研究人员对可以使用的1780次发作进行分析。162名患者在中期随访期间死亡(中位数23(IQR 4-38)个月); 死亡率为4.72/100pry。在多变量Cox回归分析中,随着NT-proBNP水平每增加五分位数死亡风险增加1.53(HR; 95%CI为1.27-1.83; p<0.001),而hs-TnT每增加五分位数为1.31(HR; 95%CI为1.10-1.55; p=0.002)。没有观察到NT-proBNP和hs-TnT水平之间的相互作用。

由此可见,NT-proBNP和hs-TnT水平升高与急诊症状性房颤患者的中期死亡率增加独立相关。

原始出处:

Jan Niederdöckl.et al.Cardiac biomarkers predict mortality in emergency patients presenting with atrial fibrillation.Heart. 2018.http://dx.doi.org/10.1136/heartjnl-2018-313145

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    2018-11-13 zhaojie88
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    2018-11-13 slcumt
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