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Neurology:左心房疾病是缺血性卒中的独立危险因素

2016-07-18 phylis 译 MedSci原创

背景:最近报道显示左心房疾病是缺血性卒中的独立危险因素,研究者试图探讨心房内传导阻滞(aIAB)是否是脑卒中的独立的危险因素。方法:研究者检查社区动脉粥样硬化风险研究(ARIC)中的14716患者,aIAB和缺血性卒中发生之间的关系(平均年龄54±5.8岁;55%女性;26%为黑人)。在ARIC研究期间(1987-1989),从基线数字心电图识别aLAB患者,并对其进行3次随访研究访问(1990-

背景:最近报道显示左心房疾病是缺血性卒中的独立危险因素,研究者试图探讨心房内传导阻滞(aIAB)是否是脑卒中的独立的危险因素。

方法:研究者检查社区动脉粥样硬化风险研究(ARIC)中的14716患者,aIAB和缺血性卒中发生之间的关系(平均年龄54±5.8岁;55%女性;26%为黑人)。在ARIC研究期间(1987-1989),从基线数字心电图识别aLAB患者,并对其进行3次随访研究访问(1990-1992年,1993-1995年,和1996-1998年)。对缺血性脑卒中事件的确定直至2010年12月31日。

结果:有266(1.8%)例参与者有aIAB的证据。随访时间的中位数为22年,共有916(6.2%)例缺血性卒中事件发生。有aIAB(发生率为8.05,95% CI  5.7,11.4)的患者缺血性卒中发病率(每1000人年)是无aIAB患者的两倍以上(发病率3.14,95% CI 2.94,3.35)。在多变量Cox回归分析中,校正脑卒中潜在的危险因素和潜在的混杂因素,aIAB与缺血性卒中的风险增加相关(HR 1.63,95% CI 1.13-2.34)。按照年龄、性别和种族分层后,结果是一致。

结论:在ARIC研究中、aIAB与缺血性卒中相关的事件发生相关,这就显示左心房疾病是脑卒中独立的危险因素。

原始出处:

O'Neal WT, Kamel H, et al. Advanced interatrial block and ischemic stroke: The Atherosclerosis Risk in Communities Study. Neurology. 2016 Jun 24.


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  5. [GetPortalCommentsPageByObjectIdResponse(id=1806098, encodeId=7e6618060982c, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Jul 30 15:04:00 CST 2016, time=2016-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659695, encodeId=6b2e1659695e9, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Fri Jun 23 03:04:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037173, encodeId=a5a5203e17372, content=<a href='/topic/show?id=9be468126d4' target=_blank style='color:#2F92EE;'>#独立危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68126, encryptionId=9be468126d4, topicName=独立危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Sat Feb 04 00:04:00 CST 2017, time=2017-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892777, encodeId=f99c1892e77be, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Oct 02 13:04:00 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145489, encodeId=b5d414548996, content=赞了,认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:25:12 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999726, encodeId=7e4a1999e26fa, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Aug 10 22:04:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626816, encodeId=7c70162681697, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Wed Jul 20 12:04:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    赞了,认真探究、学习。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1806098, encodeId=7e6618060982c, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Jul 30 15:04:00 CST 2016, time=2016-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659695, encodeId=6b2e1659695e9, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Fri Jun 23 03:04:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037173, encodeId=a5a5203e17372, content=<a href='/topic/show?id=9be468126d4' target=_blank style='color:#2F92EE;'>#独立危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68126, encryptionId=9be468126d4, topicName=独立危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Sat Feb 04 00:04:00 CST 2017, time=2017-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892777, encodeId=f99c1892e77be, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Oct 02 13:04:00 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145489, encodeId=b5d414548996, content=赞了,认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:25:12 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999726, encodeId=7e4a1999e26fa, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Aug 10 22:04:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626816, encodeId=7c70162681697, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Wed Jul 20 12:04:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-08-10 yinhl1978
  7. [GetPortalCommentsPageByObjectIdResponse(id=1806098, encodeId=7e6618060982c, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Jul 30 15:04:00 CST 2016, time=2016-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659695, encodeId=6b2e1659695e9, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Fri Jun 23 03:04:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037173, encodeId=a5a5203e17372, content=<a href='/topic/show?id=9be468126d4' target=_blank style='color:#2F92EE;'>#独立危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68126, encryptionId=9be468126d4, topicName=独立危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Sat Feb 04 00:04:00 CST 2017, time=2017-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892777, encodeId=f99c1892e77be, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Oct 02 13:04:00 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145489, encodeId=b5d414548996, content=赞了,认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:25:12 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999726, encodeId=7e4a1999e26fa, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Aug 10 22:04:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626816, encodeId=7c70162681697, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Wed Jul 20 12:04:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-07-20 sodoo
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