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PNAS：慢性睡眠缩短降低人的警觉性

2018-05-24 海北 MedSci原创

睡眠不足
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数百万人通常每天保持清醒超过18个小时，这导致人体性能的下降。但是，这些功能障碍是延长的觉醒或是相关的缩短的睡眠持续时间的结果是未知的。

数百万人通常每天保持清醒超过18个小时，这导致人体性能的下降。但是，这些功能障碍是延长的觉醒或是相关的缩短的睡眠持续时间的结果是未知的。
因此，来自哈佛医学院的研究人员设计了32天住院治疗方案，测试了受试者客观反应时间表现和主观警觉性的变化。参与者被安排进行20个小时的睡眠清醒周期，其中清醒时间小于16个小时。参与者被随机划分为两组：标准睡眠：唤醒率（1 ：2）；或慢性睡眠限制（CSR）比率（1：3.3）。
该实验允许确定独立于延长觉醒的睡眠缺陷的贡献，因为CSR条件下的个体清醒时间仅为15.33小时（小于24小时内通常的16小时清醒），并且睡眠时间为每个周期持续4.67小时。
研究人员发现，即使没有延长清醒时间，慢性短暂睡眠持续时间也使神经行为反应时间加倍，注意力失误增加5倍，但没有统一减少自我报告的警觉性。此外，在昼夜周期的夜间，这些神经行为表现的损伤恶化，并且在昼夜周期的白天未恢复，表明即使在白天唤醒的昼夜节律促进期间，也表达来自CSR的稳态累积的有害作用。
这些发现揭示了人体生物学的一个基本方面：即使没有延长觉醒，相当于每24小时睡眠时间5.6小时的慢性睡眠持续时间不足会损害神经行为表现和自我评估的警觉性。

原始出处：

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    2018-05-31 drwjr

    #PNAS#

    0

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Thu May 24 15:31:01 CST 2018, time=2018-05-24, status=1, ipAttribution=)]
    2018-05-25 Y—xianghai

    学习了长知识

    0

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Thu May 24 15:31:01 CST 2018, time=2018-05-24, status=1, ipAttribution=)]
    2018-05-25 Y—xianghai

    学习了长知识

    0

  4. 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    2018-05-25 Y—xianghai

    学习了长知识

    0

  5. 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    2018-05-25 Y—xianghai

    学习了长知识

    0

  6. 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    2018-05-25 Y—xianghai

    学习了长知识

    0

  7. 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    2018-05-25 Y—xianghai

    学习了长知识

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Thu May 24 15:31:01 CST 2018, time=2018-05-24, status=1, ipAttribution=)]
    2018-05-25 Y—xianghai

    学习了长知识

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Thu May 24 15:31:01 CST 2018, time=2018-05-24, status=1, ipAttribution=)]
    2018-05-25 吴教授

    是的.年轻人很多睡眠时间都维持在5.6个小时

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Thu May 24 15:31:01 CST 2018, time=2018-05-24, status=1, ipAttribution=)]
    2018-05-24 baihao215

    医护人员的夜班呢?

    0

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