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睡眠问题与阿尔茨海默氏症蛋白的变化有关

2017-11-10 MedSci MedSci原创

美国的研究人员发现,睡眠障碍、阻塞性睡眠呼吸暂停和与阿尔茨海默病相关的蛋白质水平之间存在联系。他们的研究结果发表在今天的《美国呼吸与危重病医学杂志》(American Journal of Respiratory and Critical Care Medicine)上。阻塞性睡眠呼吸暂停(OSA)指的是呼吸暂停,当一个人的上气道在睡眠时关闭。睡眠问题,包括阻塞性睡眠呼吸暂停综合症(OSA),之前

美国的研究人员发现,睡眠障碍、阻塞性睡眠呼吸暂停和与阿尔茨海默病相关的蛋白质水平之间存在联系。他们的研究结果发表在今天的《美国呼吸与危重病医学杂志》(American Journal of Respiratory and Critical Care Medicine)上。阻塞性睡眠呼吸暂停(OSA)指的是呼吸暂停,当一个人的上气道在睡眠时关闭。睡眠问题,包括阻塞性睡眠呼吸暂停综合症(OSA),之前一直与痴呆的风险增加有关,也与阿尔茨海默氏症的蛋白质--淀粉样蛋白--在大脑中形成的迹象有关。关于睡眠问题是否会增加阿尔茨海默氏症的风险,或者早期阿尔茨海默氏症的改变可能会导致睡眠中断,证据尚不清楚。科学家们研究了208位年龄在55到90岁之间没有痴呆症的人群。参与者提供了睡眠质量和打鼾史的信息,并通过一个家庭睡眠记录装置对有OSA症状的进行了两晚以上的监测。研究还包括记忆力和思维测试; 腰椎穿刺,使科学家能够分析脊髓液中淀粉样蛋白的水平; 而PET脑部扫描则显示出大脑中淀粉样蛋白的区域。研究人员将这些测试的结果与两年后的研究结果进行了比较。科学家发现OSA很常见, 其中53%的参与者受影响。

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