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Am J Psychiatry:幼年贫穷易导致孩子大脑结构改变并易患抑郁症

2016-01-21 QQduhp 译 MedSci原创

Deanna M.Barchb博士领导进行这项研究,研究结果发表在Psychiatry。既往研究结果表明,生活在贫困环境中的儿童大脑中的灰质和白质体积相比生活在富裕家庭的儿童少,因此获得的学术成就和成功相对较少。 在最新研究中,研究人员开始探究儿童的贫困环境是否可导致大脑中一些影响情绪和抑郁结构发生改变,进而增加民众今后抑郁的风险。因为既往研究表明,成长在贫困家庭的孩子患精神疾病的风险更高,认知和

Deanna M.Barchb博士领导进行的这项研究,研究结果发表在Am J Psychiatry。

既往研究结果表明,生活在贫困环境中的儿童大脑中的灰质和白质体积比生活在富裕家庭的儿童小,因此获得的学术成就和成功相对较少。
 
在最新研究中,研究人员开始探究儿童的贫困环境是否可导致大脑中一些影响情绪和抑郁结构发生改变,进而增加民众今后抑郁的风险。因为既往研究表明,成长在贫困家庭的孩子患精神疾病的风险更高,认知和受教育程度及学术成就更少。 

华盛顿医学院精神病学教授Barch和他的同事招募了105名3-5岁的学龄前儿童开展研究。

研究人员使用供需比(即家庭花销占其总收入的比例来评估参与者家庭的规模及收入情况)。目前,美国联邦贫困家庭收入阈值为一个四口之家24250美元/年。当孩子7-12岁时,参与研究的孩子们接受功能性磁共振成像(fMRI),研究人员对他们的海马体(与民众学习、记忆和压力调节等密切相关的大脑区域)和杏仁核(与调节压力和情绪有关的大脑区域)进行研究。 

与高收入家庭的学龄前儿童相比,来自低收入家庭的孩子大脑左侧海马区和右额叶皮质、右杏仁核和右侧舌回关联较弱。这种关联减弱使得孩子在9-10岁时易患抑郁症。

Barch认为,在这项研究中,大脑结构与关联的变化将有助于我们更好地认识机体调节情绪和压力的机制。 

研究人员认为,早期改善孩子的家庭环境有助于调节儿童的情绪,减少其出现抑郁症的风险。

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    2016-04-16 zhzhxiang
  4. [GetPortalCommentsPageByObjectIdResponse(id=1791972, encodeId=e33b1e91972c4, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Thu Jul 07 11:18:00 CST 2016, time=2016-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077935, encodeId=ce7920e793500, content=<a href='/topic/show?id=dffd4395588' target=_blank style='color:#2F92EE;'>#大脑结构改变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43955, encryptionId=dffd4395588, topicName=大脑结构改变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Sat Jul 16 02:18:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745037, encodeId=ea541e45037cd, content=<a href='/topic/show?id=e8629244096' target=_blank style='color:#2F92EE;'>#贫穷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92440, encryptionId=e8629244096, topicName=贫穷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=289c35501756, createdName=zhzhxiang, createdTime=Sat Apr 16 03:18:00 CST 2016, time=2016-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66906, encodeId=275566906f9, content=唉,唉呀妈呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 02 21:58:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66907, encodeId=79c46690e65, content=无可奈何, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 02 21:58:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61500, encodeId=d1106150064, content=这也行, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 23:23:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61148, encodeId=facf6114864, content=扯淡, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 18:56:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61149, encodeId=5fee6114937, content=神经病, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 18:56:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59023, encodeId=5adb5902388, content=穷且益坚, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 24 18:06:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424016, encodeId=f99b14240164f, content=<a href='/topic/show?id=34db439533f' target=_blank style='color:#2F92EE;'>#大脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43953, encryptionId=34db439533f, topicName=大脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d9a3889985, createdName=shanyongle, createdTime=Sat Jan 23 00:18:00 CST 2016, time=2016-01-23, status=1, ipAttribution=)]
    2016-03-02 忠诚向上

    唉,唉呀妈呀

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1791972, encodeId=e33b1e91972c4, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Thu Jul 07 11:18:00 CST 2016, time=2016-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077935, encodeId=ce7920e793500, content=<a href='/topic/show?id=dffd4395588' target=_blank style='color:#2F92EE;'>#大脑结构改变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43955, encryptionId=dffd4395588, topicName=大脑结构改变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Sat Jul 16 02:18:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745037, encodeId=ea541e45037cd, content=<a href='/topic/show?id=e8629244096' target=_blank style='color:#2F92EE;'>#贫穷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92440, encryptionId=e8629244096, topicName=贫穷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=289c35501756, createdName=zhzhxiang, createdTime=Sat Apr 16 03:18:00 CST 2016, time=2016-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66906, encodeId=275566906f9, content=唉,唉呀妈呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 02 21:58:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66907, encodeId=79c46690e65, content=无可奈何, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 02 21:58:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61500, encodeId=d1106150064, content=这也行, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Jan 27 23:23:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61148, encodeId=facf6114864, content=扯淡, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 18:56:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61149, encodeId=5fee6114937, content=神经病, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 18:56:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59023, encodeId=5adb5902388, content=穷且益坚, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 24 18:06:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424016, encodeId=f99b14240164f, content=<a href='/topic/show?id=34db439533f' target=_blank style='color:#2F92EE;'>#大脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43953, encryptionId=34db439533f, topicName=大脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d9a3889985, createdName=shanyongle, createdTime=Sat Jan 23 00:18:00 CST 2016, time=2016-01-23, status=1, ipAttribution=)]
    2016-03-02 忠诚向上

    无可奈何

    0

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    2016-01-27 文医生

    这也行

    0

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    2016-01-27 李继凯

    扯淡

    0

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    2016-01-27 李继凯

    神经病

    0

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    2016-01-24 1de3b290m83(暂无匿称)

    穷且益坚

    0

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BJOG:准爸爸的抑郁情绪增加胎儿早产风险

该研究发表在BJOG,由瑞典健康研究中心的Anders Hjern教授及同事指导进行。既往研究证实,孕妇若出现抑郁则会增加胎儿早产和低出生体重儿的风险。 妊娠期<37周(259天)出生的新生儿称为早产儿,妊娠期<32周(224天)则为极度早产儿。胎龄在37足周以前出生的活产婴儿称为早产儿或未成熟儿。早产是导致高收入和中等收入国家婴儿死亡的主要原因。WHO表示,早产对幸存的胎儿有一系列不

Medicine:痛风患者发生抑郁障碍的风险较高

抑郁障碍患者的代谢异常比较常见。然而,痛风和抑郁症之间的关系尚不清楚。研究者探讨了痛风,抗痛风的药物和抑郁障碍发生的相关风险的关系。这项队列研究中,研究者从国家健康保险研究数据库招募了34050例痛风患者为痛风组,68100例(无痛风)的对照组,收集样本的数据。研究主要终点为,随访期间抑郁症的诊断。对所有受试者进行随访至诊断为抑郁症,从研究中退出或者研究结束。应用卡方检验分析分类变量和t检验分析连

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