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Int J Cardiol:糖尿病病程和并发症与感染性心内膜炎的相关风险

2018-10-02 xing.T MedSci原创

由此可见,该研究显示IE的风险随着DM病程和严重程度逐步增加,并且与年龄和已知合并症无关。

糖尿病(DM)的长病程与感染风险增加有关,但尚无研究关注DM的病程与感染性心内膜炎(IE)的相关风险。近日,血管领域权威杂志International Journal of Cardiology上针对这些问题发表了一篇研究文章。

研究人员确定了1996-2015年期间丹麦处方登记中心的DM患者。DM的病程在随访期间分为:0-5年、5-10年、10-15年和>15年。根据研究组别,研究人员使用多变量调整泊松回归计算发病率比率(IRR),并使用经验证的糖尿病并发症严重程度指数(DCSI)作为时间变化协变量来研究DM晚期并发症与IE相关风险。

研究人员纳入了299551例DM患者。在DM病程为0-5年、5-10年、10-15年和>15年的患者中,IE的发生率分别为0.24、0.33、0.58和0.96例IE/1000人每年。与病程为0-5年的DM患者相比,病程为5-10年、10-15年和>15年的DM患者IE的风险较高,IRR分别为1.24(95%CI为1.02-1.51)、1.92(95%CI为1.52-2.43)和3.05(95%CI为2.11-4.40)。与DCSI评分为0的患者相比,DCSI评分为2、3和>3的患者IE风险更高,分别有IRR=1.78(95%CI为1.34-2.36)、IRR=2.34(95%CI为1.73-3.16)和IRR=2.59(95%CI为1.92-3.48)。

由此可见,该研究显示IE的风险随着DM病程和严重程度逐步增加,并且与年龄和已知合并症无关。

原始出处:

LaugeØstergaard,et al. Duration and complications of diabetes mellitus and the associated risk of infective endocarditis.International Journal of Cardiology.2018.https://www.sciencedirect.com/science/article/pii/S0167527318334247

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    2019-02-07 丁鹏鹏
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1781960, encodeId=345e1e81960e7, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Feb 19 16:02:00 CST 2019, time=2019-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758032, encodeId=89991e580326b, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Thu Feb 07 02:02:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655434, encodeId=61d91655434a5, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=583d24724321, createdName=charl1234575, createdTime=Tue Apr 02 23:02:00 CST 2019, time=2019-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708483, encodeId=f0bb1e08483e3, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Thu Oct 18 05:02:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350714, encodeId=be0a1350e14ee, content=<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50878, encryptionId=a32d508e8c3, topicName=心内膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Oct 04 11:02:00 CST 2018, time=2018-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347699, encodeId=e08734e69920, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Tue Oct 02 23:21:41 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041878, encodeId=963e10418e894, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Oct 02 23:02:00 CST 2018, time=2018-10-02, status=1, ipAttribution=)]
    2018-10-02 医者仁心5538

    学习了

    0

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    2018-10-02 misszhang

    谢谢MedSci提供最新的资讯

    0

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