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BMC Cancer:前列腺癌和小细胞癌谱系关系研究

2019-06-12 AlexYang MedSci原创

前列腺癌具有不同的形态,而这些不同的形态可以影响患者的治疗结果。这个情况促使了人们思考分化的、可以治疗的前列腺癌与分化不良、不太可能治疗的癌症(包括小细胞癌)之间的关系以及前列腺癌分化的潜在分子机制。最近,有研究人员利用非恶性肿瘤/小细胞癌PDX LuCaP细胞系进行了干细胞转录因子(scTF)LIN28A、NANOG、POU5F1和SOX2的表达分析。研究发现,scTF在小细胞癌LuCaP 93

前列腺癌具有不同的形态,而这些不同的形态可以影响患者的治疗结果。这个情况促使了人们思考分化的、可以治疗的前列腺癌与分化不良、不太可能治疗的癌症(包括小细胞癌)之间的关系以及前列腺癌分化的潜在分子机制。

最近,有研究人员利用非恶性肿瘤/小细胞癌PDX LuCaP细胞系进行了干细胞转录因子(scTF)LIN28A、NANOG、POU5F1和SOX2的表达分析。研究发现,scTF在小细胞癌LuCaP 93、145.1和145.2以及非恶性肿瘤LuCaP 173.1和173.2A中具有表达。scTF转染能够改变前列腺非小细胞瘤细胞和纤维瘤细胞的基因表达。转染的细胞生长群落形态类似茎状。另外,B2M的表达在转染细胞中表达量降低不少于10倍。低的B2M表达同样也是LuCaP 145.1的特征。相反的,当干细胞分化时,B2M表达量增加。

最后,研究人员指出,他们的研究表明了恶性肿瘤中非恶性肿瘤/小细胞肿瘤的产生可能是通过激活能够诱导癌症去分化的scTF基因来实现的。

原始出处:

Kanan AD, Corey E, Vêncio RZN et al. Lineage relationship between prostate adenocarcinoma and small cell carcinoma. BMC Cancer. 30 May 2019

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    2019-06-12 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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    2019-06-12 飛歌

    学习了很有用不错

    0

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