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Cancer Res：研究揭示癌症干细胞基因组不稳定性和免疫逃避新机制

2017-11-25 Emma MedSci原创

blebbishields癌症基因组不稳定性免疫逃避
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在医学上，癌（cancer）是指起源于上皮组织的恶性肿瘤，是恶性肿瘤中最常见的一类。癌症具有细胞分化和增殖异常、生长失去控制、浸润性和转移性等生物学特征，其发生是一个多因子、多步骤的复杂过程，分为致癌、促癌、演进三个过程。

在医学上，癌（cancer）是指起源于上皮组织的恶性肿瘤，是恶性肿瘤中最常见的一类。癌症具有细胞分化和增殖异常、生长失去控制、浸润性和转移性等生物学特征，其发生是一个多因子、多步骤的复杂过程，分为致癌、促癌、演进三个过程。基因组不稳定性和免疫逃避是癌症的标志，已经凋亡的癌症干细胞可以通过构建来自凋亡小体的"blebbishields"进行细胞转化从而避免细胞死亡。

发表于cancer research的一篇文章报道了基因组不稳定性与吞噬逃避之间的一种新的联系，并且这是由blebbishield紧急程序所协调的。在基因组不稳定性方面，Blebbishield紧急程序能够避开了基因组不稳定性的检查，在细胞转化的不同阶段，表达基因组不稳定的相关基因，表现出染色体不稳定性，并促进了核大小的增加。在逃避吞噬方面，Blebbishields与免疫细胞融合以避免吞噬作用，并且所得到的杂交细胞表现出增加的迁移，肿瘤发生，转移，血红细胞向肿瘤募集，诱发肝脾肿大，基因组不稳定性，Blebbishields紧急程序和吞噬逃避作用会导致预后不良。

该研究表明，blebbishield紧急程序能够驱动凋亡癌症干细胞逃避染色体不稳定性和吞噬检查点，为癌症相关研究提供重要参考。

原始出处：
Goodwin G, et al. The Blebbishield Emergency Program Overrides Chromosomal Instability and PhagocytosisCheckpoints in Cancer Stem Cells. Cancer Res. 2017 Nov 15;77(22):6144-6156. doi: 10.1158/0008-5472.CAN-17-0522. Epub 2017 Aug 30.

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    2018-01-05 jiangfeng5067

    #稳定性#

    0

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    2018-08-14 ms6897892027066920

    #基因组不稳定性#

    0

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    2017-11-27 1249884fm87暂无昵称

    #癌症干细胞#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1900469, encodeId=dc391900469ce, content=<a href='/topic/show?id=0983e529745' target=_blank style='color:#2F92EE;'>#稳定性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75297, encryptionId=0983e529745, topicName=稳定性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Fri Jan 05 07:41:00 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006230, encodeId=1bc7200623021, content=<a href='/topic/show?id=9307418196e' target=_blank style='color:#2F92EE;'>#基因组不稳定性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41819, encryptionId=9307418196e, topicName=基因组不稳定性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Aug 14 23:41:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333004, encodeId=ddf113330042c, content=<a href='/topic/show?id=2ab5e13481f' target=_blank style='color:#2F92EE;'>#癌症干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71348, encryptionId=2ab5e13481f, topicName=癌症干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1d2500084, createdName=1249884fm87暂无昵称, createdTime=Mon Nov 27 08:41:00 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264485, encodeId=000526448575, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Sun Nov 26 11:07:40 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264244, encodeId=f79826424493, content=学习了.好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Nov 25 18:58:58 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264238, encodeId=04f826423868, content=继续学习. , beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Nov 25 18:57:06 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264237, encodeId=186c26423ebb, content=继续关注. , beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Nov 25 18:57:00 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264227, encodeId=600b26422ebe, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 25 18:28:41 CST 2017, time=2017-11-25, status=1, ipAttribution=)]
    2017-11-26 海之蓝

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1900469, encodeId=dc391900469ce, content=<a href='/topic/show?id=0983e529745' target=_blank style='color:#2F92EE;'>#稳定性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75297, encryptionId=0983e529745, topicName=稳定性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Fri Jan 05 07:41:00 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006230, encodeId=1bc7200623021, content=<a href='/topic/show?id=9307418196e' target=_blank style='color:#2F92EE;'>#基因组不稳定性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41819, encryptionId=9307418196e, topicName=基因组不稳定性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Aug 14 23:41:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333004, encodeId=ddf113330042c, content=<a href='/topic/show?id=2ab5e13481f' target=_blank style='color:#2F92EE;'>#癌症干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71348, encryptionId=2ab5e13481f, topicName=癌症干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1d2500084, createdName=1249884fm87暂无昵称, createdTime=Mon Nov 27 08:41:00 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264485, encodeId=000526448575, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Sun Nov 26 11:07:40 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264244, encodeId=f79826424493, content=学习了.好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Nov 25 18:58:58 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264238, encodeId=04f826423868, content=继续学习. , beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Nov 25 18:57:06 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264237, encodeId=186c26423ebb, content=继续关注. , beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Nov 25 18:57:00 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264227, encodeId=600b26422ebe, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 25 18:28:41 CST 2017, time=2017-11-25, status=1, ipAttribution=)]
    2017-11-25 1ddf0692m34(暂无匿称)

    学习了.好文章

    0

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    2017-11-25 doctorJiangchao

    继续学习.

    0

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    2017-11-25 doctorJiangchao

    继续关注.

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1900469, encodeId=dc391900469ce, content=<a href='/topic/show?id=0983e529745' target=_blank style='color:#2F92EE;'>#稳定性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75297, encryptionId=0983e529745, topicName=稳定性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Fri Jan 05 07:41:00 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006230, encodeId=1bc7200623021, content=<a href='/topic/show?id=9307418196e' target=_blank style='color:#2F92EE;'>#基因组不稳定性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41819, encryptionId=9307418196e, topicName=基因组不稳定性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Aug 14 23:41:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333004, encodeId=ddf113330042c, content=<a href='/topic/show?id=2ab5e13481f' target=_blank style='color:#2F92EE;'>#癌症干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71348, encryptionId=2ab5e13481f, topicName=癌症干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1d2500084, createdName=1249884fm87暂无昵称, createdTime=Mon Nov 27 08:41:00 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264485, encodeId=000526448575, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Sun Nov 26 11:07:40 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264244, encodeId=f79826424493, content=学习了.好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Nov 25 18:58:58 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264238, encodeId=04f826423868, content=继续学习. , beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Nov 25 18:57:06 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264237, encodeId=186c26423ebb, content=继续关注. , beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Nov 25 18:57:00 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264227, encodeId=600b26422ebe, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 25 18:28:41 CST 2017, time=2017-11-25, status=1, ipAttribution=)]
    2017-11-25 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

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