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Stroke:非高密度脂蛋白胆固醇可预测急性缺血性卒中患者的不良结局

2021-05-20 MedSci原创 MedSci原创

non-HDL-C水平可能是急性缺血性卒中患者1年内复发和全因死亡的预测因子。

非高密度脂蛋白胆固醇(non-HDL-C)与血管疾病患者的不良结局显著相关。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在探究non-HDL-C水平与急性缺血性卒中患者不良结局之间的关系。

19604例急性缺血性卒中患者在中国国家卒中登记处II进行了登记,其中16113例患者均检查了总胆固醇和HDL-C水平。研究人员根据non-HDL-C的五分位数将患者分为5组。该研究的结局包括一年内反复发作的缺血性卒中、颅内出血和全因死亡。研究人员通过Cox回归模型分析了non-HDL-C与结局风险之间的关系。

non-HDL-C水平与卒中复发和全因死亡的关系

在16113例患者中,non-HDL-C水平的中位数(四分位间距)为3.41(2.78-4.10)mmol/L。调整混杂变量后,相比于第三个五分位数,non-HDL-C水平处于最高五分位数的患者1年内复发性缺血性卒中的风险较高(调整后的风险比为1.46 [95%CI为1.20-1.77])。相比于第三个五分位数,non-HDL-C水平处于最高和最低五分位数的患者在1年内发生全因死亡的风险较高(分别有调整后的风险比为1.22 [95%CI为1.01-1.47],调整后的风险比为1.40[95%CI为1.15-1.70])。但是,non-HDL-C水平对颅内出血没有显著预测作用。

由此可见,non-HDL-C水平可能是急性缺血性卒中患者1年内复发和全因死亡的预测因子

原始出处:

Guangyao Wang.et al.Non–High-Density Lipoprotein Cholesterol Predicts Adverse Outcomes in Acute Ischemic Stroke.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.030783

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    2021-05-20 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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