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Cerebrovasc Dis:延髓背外侧梗死伴髓外病变的患者长期治疗的结局较好

2018-04-18 国际循环编辑部 国际循环

延髓背外侧梗死(LMI)是一种常见疾病,其造成的损伤通常仅限于侧髓,但仍有部分患者出现大脑其他部位的梗死。目前,单纯LMI(LMIpr)患者的临床特点及预后已有所了解,但关于LMIpr患者与出现其他部位损伤(LMIpl)的患者在临床特点、预后以及预后相关因素方面是否存在差异尚未可知。

延髓背外侧梗死(LMI)是一种常见疾病,其造成的损伤通常仅限于侧髓,但仍有部分患者出现大脑其他部位的梗死。目前,单纯LMI(LMIpr)患者的临床特点及预后已有所了解,但关于LMIpr患者与出现其他部位损伤(LMIpl)的患者在临床特点、预后以及预后相关因素方面是否存在差异尚未可知。

研究者纳入248例确诊LMI的患者,其中LMIpr患者161例(64.9%),LMIpl患者87例(35.1%),希望比较两类患者在临床统计学特点、住院结局[ICU入住,出院时肺炎及改良Rankin量表评分(mRS)]、长期残留症状及其他结局事件[卒中、急性冠状动脉综合征(ACS)、死亡以及随访期间mRS]等方面的差异。此外,研究者也分析了导致两类患者在随访期出现不良功能结局的相关因素。

结果显示,LMIpl患者的住院结局较差,表现为其ICU入住比例和肺炎发生率较高,出院时的mRS也更高(P<0.001)。两类患者在随访期的卒中和ACS发作、死亡率和功能结局的情况没有差异。但LMIpl患者的长期治疗效果更好,相比之下,LMIpr患者更容易出现如眩晕(P=0.002),吞咽困难(P=0.04)以及感觉障碍(P<0.001)等残留神经症状。此外,导致两类患者出现长期残留症状的影响因素不同,其中LMI的主要损伤部位可导致LMIpr患者出现不良的功能结局(P=0.041),而出现侧髓以外部位的病变与LMIpl患者出现良好的功能结局相关(P=0.030)。

该研究提示,尽管LMIpr的短期疗效优于LMIpl患者,但LMIpr患者的长期残留症状更为常见。LMI和髓外病变的位置可分别影响LMIpr和LMIpl患者的长期功能结局。

原始出处:
Kang H.G., Kim B.J., Lee S.H., et al. Lateral Medullary Infarction with or without Extra-Lateral Medullary Lesions: What Is the Difference? Cerebrovasc Dis. 2018;45:132–140

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    2019-04-04 quxin068
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  7. [GetPortalCommentsPageByObjectIdResponse(id=2055548, encodeId=0f832055548d9, content=<a href='/topic/show?id=4ebf9e016c6' target=_blank style='color:#2F92EE;'>#长期治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97016, encryptionId=4ebf9e016c6, topicName=长期治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Fri Dec 14 04:46:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938830, encodeId=d8d01938830e6, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Apr 04 10:46:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821990, encodeId=a8bf1821990c5, content=<a href='/topic/show?id=0b2110210e2e' target=_blank style='color:#2F92EE;'>#髓外病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102107, encryptionId=0b2110210e2e, topicName=髓外病变)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Wed Nov 14 10:46:00 CST 2018, time=2018-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056916, encodeId=e6c42056916ce, content=<a href='/topic/show?id=f00a4956176' target=_blank style='color:#2F92EE;'>#延髓背外侧梗死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49561, encryptionId=f00a4956176, topicName=延髓背外侧梗死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=685a124, createdName=muzishouyi, createdTime=Mon Mar 11 15:46:00 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012631, encodeId=787120126318c, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Jan 01 19:46:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689835, encodeId=59d7168983516, content=<a href='/topic/show?id=f86c4955e59' target=_blank style='color:#2F92EE;'>#延髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49557, encryptionId=f86c4955e59, topicName=延髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c8428890315, createdName=446798725_87912774, createdTime=Tue Jul 17 17:46:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307061, encodeId=c88630e06100, content=不错的文章.值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Wed Apr 18 22:56:40 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307053, encodeId=5acb30e05361, content=延髓背外侧梗死(LMI)是一种常见疾病.其造成的损伤通常仅限于侧髓.但仍有部分患者出现大脑其他部位的梗死.目前.单纯LMI(LMIpr)患者的临床特点及预后已有所了解.但关于LMIpr患者与出现其他部位损伤(LMIpl)的患者在临床特点.预后以及预后相关因素方面是否存在差异尚未可知., beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Apr 18 22:42:22 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307033, encodeId=867130e033aa, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Apr 18 22:33:26 CST 2018, time=2018-04-18, status=1, ipAttribution=)]
    2018-04-18 131****2916

    不错的文章.值得推荐

    0

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    2018-04-18 有备才能无患

    延髓背外侧梗死(LMI)是一种常见疾病.其造成的损伤通常仅限于侧髓.但仍有部分患者出现大脑其他部位的梗死.目前.单纯LMI(LMIpr)患者的临床特点及预后已有所了解.但关于LMIpr患者与出现其他部位损伤(LMIpl)的患者在临床特点.预后以及预后相关因素方面是否存在差异尚未可知.

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2055548, encodeId=0f832055548d9, content=<a href='/topic/show?id=4ebf9e016c6' target=_blank style='color:#2F92EE;'>#长期治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97016, encryptionId=4ebf9e016c6, topicName=长期治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Fri Dec 14 04:46:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938830, encodeId=d8d01938830e6, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Apr 04 10:46:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821990, encodeId=a8bf1821990c5, content=<a href='/topic/show?id=0b2110210e2e' target=_blank style='color:#2F92EE;'>#髓外病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102107, encryptionId=0b2110210e2e, topicName=髓外病变)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Wed Nov 14 10:46:00 CST 2018, time=2018-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056916, encodeId=e6c42056916ce, content=<a href='/topic/show?id=f00a4956176' target=_blank style='color:#2F92EE;'>#延髓背外侧梗死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49561, encryptionId=f00a4956176, topicName=延髓背外侧梗死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=685a124, createdName=muzishouyi, createdTime=Mon Mar 11 15:46:00 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012631, encodeId=787120126318c, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Jan 01 19:46:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689835, encodeId=59d7168983516, content=<a href='/topic/show?id=f86c4955e59' target=_blank style='color:#2F92EE;'>#延髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49557, encryptionId=f86c4955e59, topicName=延髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c8428890315, createdName=446798725_87912774, createdTime=Tue Jul 17 17:46:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307061, encodeId=c88630e06100, content=不错的文章.值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Wed Apr 18 22:56:40 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307053, encodeId=5acb30e05361, content=延髓背外侧梗死(LMI)是一种常见疾病.其造成的损伤通常仅限于侧髓.但仍有部分患者出现大脑其他部位的梗死.目前.单纯LMI(LMIpr)患者的临床特点及预后已有所了解.但关于LMIpr患者与出现其他部位损伤(LMIpl)的患者在临床特点.预后以及预后相关因素方面是否存在差异尚未可知., beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Apr 18 22:42:22 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307033, encodeId=867130e033aa, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Apr 18 22:33:26 CST 2018, time=2018-04-18, status=1, ipAttribution=)]
    2018-04-18 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

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