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Radiology:当进行碘对比剂CT增强检查时发生急性轻度过敏反应时该咋办?

2018-07-23 shaosai MedSci原创

本研究旨在评价广泛应用于碘对比剂(ICM)复发性超敏反应(HSRs)的预防中前驱给药方案,现今尚无经典的对轻度反应患者干预的预防方案。

本研究旨在评价广泛应用于碘对比剂(ICM)复发性超敏反应(HSRs)的预防中前驱给药方案,现今尚无经典的对轻度反应患者干预的预防方案。

分析出现轻度HSR并随后行对比剂增强CT检查患者的结果。对于前驱给药,在重新接受ICM30分钟前静脉注射4㎎扑尔敏。利用Logistic回归分析验证前驱给药方案和复发率的关系。

本研究共有1178例发生轻度HSR并再次暴露ICM3533次的患者。在这些患者中,共有1056例患者发生过敏样反应,122例患者出现胃肠道反应。在无进行前驱且进行再次注射对比剂时,复发率为31.1% (85/273次检查),仅改变对比剂时,复发率下降为12%(105 /872次检查,P < .001),而换用对比剂联合前驱药物治疗后复发率降低到7.6% (148/1947次检查; P < .001)。换用对比剂联合前驱药物治疗有助于减轻胃肠道反应发生率(16.1%到1.8%,P = .020)。然而,无论是更换ICM,还是换用对比剂联合前驱药物治疗都没有预防效果。

本研究表明,换用对比剂联合前驱药物治疗能够更好的预防对比剂导致的轻度HSR,是轻度急性HSR患者的最佳选择。根据发生副反应对比剂的种类,更换ICM应该个体化。

原始出处:


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    2018-07-26 大爰

    学习并分享!!

    0

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    2018-07-24 liumin1987

    预防碘对比剂CT增强检查时急性轻度过敏。

    0

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    2018-07-24 执着追梦

    学习,谢谢分享

    0

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    2018-07-24 飛歌

    越来越好不错

    0

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    2018-07-24 飛歌

    厉害了我的妹

    0

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J Nucl Med:林岩松团队向碘难治性甲状腺癌发起挑战

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碘是甲状腺激素的重要原料。根据2015年美国甲状腺协会(ATA)声明,正常成年人每天应摄入约0.15 mg碘元素,孕期妇女应该保持在0.22~0.25mg之间,哺乳期妇女则为0.25~0.29 mg。正常成人每日摄入量超过1.1 mg可能会导致甲状腺功能异常。对于妊娠与哺乳期妇女,考虑到过量的碘对胎儿或婴儿甲状腺的影响,碘摄取上限在0.5~1.1 mg之间。

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