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JCO:调整膳食脂肪摄入或可降低肺癌风险

2017-08-14 吴星 环球医学

越来越多的证据表明膳食习惯可影响肺癌风险。2017年7月,发表在《J Clin Oncol.》的一项研究调查了膳食脂肪摄入和肺癌风险的相关性。



越来越多的证据表明膳食习惯可影响肺癌风险。2017年7月,发表在《J Clin Oncol.》的一项研究调查了膳食脂肪摄入和肺癌风险的相关性。

目的:膳食脂肪或在肺部癌变的过程中起着重要的作用。但是,流行病学研究的结果仍然不一致。在这项对10项来自美国、欧洲和亚洲前瞻性队列研究的汇总分析中,研究者评价了总的和特定类型膳食脂肪与肺癌风险之间的相关性。

方法:使用Cox回归分析,估算每个队列的风险比(HRs)和95% CIs。通过随机或固定效应荟萃分析,合并特定研究的风险。排除前2年的随访,以考察临床前膳食变化的潜在影响。

结果:在1445850例受试者中,确定18822例突发病例(平均随访9.4年)。总脂肪酸和饱和脂肪酸摄入量较高与肺癌风险升高正相关(最高vs 最低五分位数:HR,1.07和1.14;95% CI,1.00~1.15和1.07~1.22;P均<0.001)。目前吸烟者(HR,1.23;95% CI,1.13~1.35;趋势P<0.001)饱和脂肪酸的正相关性比既往/未曾吸烟者明显(相互作用P = 0.004),鳞状细胞癌和小细胞癌(HR,分别是1.61和1.40;95% CI,1.38~1.88和1.17~1.67;P均<0.001)比其他病理组织学类型明显(异质性P<0.001)。相比而言,多不饱和脂肪酸摄入量较高与肺癌风险降低正相关(最高vs最低五分位数:HR,0.92;95% CI,0.87~0.98;P = 0.02)。多不饱和脂肪能量替代饱和脂肪5%与鳞状细胞癌和小细胞癌风险降低16%~17%相关。没有发现单不饱和脂肪方面与肺癌风险的相关性。

结论:该大型、国际队列汇总分析的结果显示,调整食物脂肪摄入,如使用多不饱和脂肪替代饱和脂肪酸,或可降低肺癌发生风险,尤其可以降低吸烟人群及鳞状细胞癌和小细胞癌的发生率。

原始出处:

Yang JJ, Yu D, Takata Y, et al. Dietary Fat Intake and Lung Cancer Risk: A Pooled Analysis. J Clin Oncol. 2017 Jul 25:JCO2017733329. doi: 10.1200/JCO.2017.73.3329.

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    2018-07-11 sjq027
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    2017-11-07 lidong40
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    2017-08-16 zhaojie88
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