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Hypertension:高浓度PM2.5暴露对中心血压的急性效应

2019-10-22 xing.T MedSci原创

由此可见,该研究结果表明,在华裔社区人群中,短期暴露于高于100μg/cm3的环境PM2.5与中心主动脉血压显著增加有关。

越来越多的人认为中心动脉血压(BP)与心血管风险之间的关系比外周BP更密切。然而,颗粒物质污染对中心主动脉BP的影响尚未证实。近日,心血管权威杂志Hypertension上发表了一篇研究文章,在这项研究中,研究人员评估了中国社区人群中短期环境细颗粒物(空气动力学直径≤2.5μm;PM2.5)暴露与中心主动脉血压之间的关联。

在最终分析中,研究人员总共进行了4715次随访,其中基线随访2151次,后续随访2564次。研究人员使用Omron HEM-9000AI机器通过桡动脉眼压计法无创地测量中心主动脉收缩压(cSBP)。来自空气污染监测站的数据被用来估计每天的PM2.5暴露量。调整临床和气象协变量的广义加性混合模型用于评估PM2.5暴露与cSBP之间的关联。

PM2.5暴露与cSBP之间的关系是非线性的,当PM2.5暴露浓度高于100μg/cm3时,可观察到cSBP的显著增加。cSBP测量当天(滞后0天)PM2.5的四分位数范围增加(80.25μg/m3)与cSBP升高2.54mmHg(95%CI为0.92-4.16)有关。除心血管疾病外,年龄、性别、体重指数、药物和合并症均未改变PM2.5与cSBP之间的关联。

由此可见,该研究结果表明,在华裔社区人群中,短期暴露于高于100μg/cm3的环境PM2.5与中心主动脉血压显著增加有关。 

原始出处:

Fangfang Fan.et al.Acute Effects of High-Level PM2.5Exposure on Central Blood Pressure.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13408

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time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374259, encodeId=b2b43e425999, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Oct 22 20:55:56 CST 2019, time=2019-10-22, status=1, ipAttribution=)]
    2020-09-22 feather89
  5. 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time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374259, encodeId=b2b43e425999, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Oct 22 20:55:56 CST 2019, time=2019-10-22, status=1, ipAttribution=)]
    2019-10-25 147612bem32暂无昵称

    写的真好

    0

  6. 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  7. 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time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374259, encodeId=b2b43e425999, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Oct 22 20:55:56 CST 2019, time=2019-10-22, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2076601, encodeId=5b6320e6601aa, content=<a href='/topic/show?id=743b5230e45' target=_blank style='color:#2F92EE;'>#急性效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52307, encryptionId=743b5230e45, topicName=急性效应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Sun Nov 24 10:23:00 CST 2019, time=2019-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655621, encodeId=2f4d16556219d, content=<a href='/topic/show?id=93e12218000' target=_blank style='color:#2F92EE;'>#中心血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22180, encryptionId=93e12218000, topicName=中心血压)], attachment=null, authenticateStatus=null, createdAvatar=null, 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time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374259, encodeId=b2b43e425999, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Oct 22 20:55:56 CST 2019, time=2019-10-22, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=2076601, encodeId=5b6320e6601aa, content=<a href='/topic/show?id=743b5230e45' target=_blank style='color:#2F92EE;'>#急性效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52307, encryptionId=743b5230e45, topicName=急性效应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Sun Nov 24 10:23:00 CST 2019, time=2019-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655621, encodeId=2f4d16556219d, content=<a href='/topic/show?id=93e12218000' target=_blank style='color:#2F92EE;'>#中心血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22180, encryptionId=93e12218000, topicName=中心血压)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  10. [GetPortalCommentsPageByObjectIdResponse(id=2076601, encodeId=5b6320e6601aa, content=<a href='/topic/show?id=743b5230e45' target=_blank style='color:#2F92EE;'>#急性效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52307, encryptionId=743b5230e45, topicName=急性效应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Sun Nov 24 10:23:00 CST 2019, time=2019-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655621, encodeId=2f4d16556219d, content=<a href='/topic/show?id=93e12218000' target=_blank style='color:#2F92EE;'>#中心血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22180, encryptionId=93e12218000, topicName=中心血压)], attachment=null, authenticateStatus=null, createdAvatar=null, 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time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374259, encodeId=b2b43e425999, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Oct 22 20:55:56 CST 2019, time=2019-10-22, status=1, ipAttribution=)]
    2019-10-22 天地飞扬

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