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Eur Radiol:殊途同归,然而视神经脊髓炎和多发性硬化的致残性因素却不尽相同!

2017-07-03 shaosai MedSci原创

视神经脊髓炎(NMO)和多发性硬化(MS)在影像学上是经常被相互作为鉴别诊断的疾病。两种疾病随着病情的进展都会造成患者功能上的残疾,而由于病理机制不同,两种疾病造成患者残疾的影响因素不同。因此,本研究旨在研究神经脊髓炎(NMO)和多发性硬化(MS)在脊髓和脑内随时间病变的进展以及病变与病情恶化间的关系。研究人员并将结果发表于影像学权威杂志Eur Radiol上。本研究共纳入了28名NMO患者、22

视神经脊髓炎(NMO)和多发性硬化(MS)在影像学上是经常被相互作为鉴别诊断的疾病。两种疾病随着病情的进展都会造成患者功能上的残疾,而由于病理机制不同,两种疾病造成患者残疾的影响因素不同。因此,本研究旨在研究神经脊髓炎(NMO)和多发性硬化(MS)在脊髓和脑内随时间病变的进展以及病变与病情恶化间的关系。研究人员并将结果发表于影像学权威杂志Eur Radiol上。

本研究共纳入了28名NMO患者、22名MS患者及20名健康志愿者(HC),并在基线时进行脊髓和脑MRI检查。 其中对25名NMO和20名MS患者进行了1年随访。在基线时测量脊髓和脑实质病变大小,上颈髓(MUCCA)、脑和丘脑平均体积及其在1年随访期间的体积变化,并进行组间比较。 对NMO和MS的进展组合非进展组组间也进行了比较。

在随访1年后, NMO患者的MUCCA显着下降,而在MS患者中并无明显变化。 脑实质体积变化百分比(PBVC)和丘脑体积变化百分比在MS患者中要明显高于NMO。 NMO患者中进展组和非进行组之间的MUCCA变化不为相同,而基线时脑病变体积和PBVC与MS患者的病情进展相关。 经1年随访得出,MUCCA的变化与NMO临床伤残有关。

脊髓萎缩与NMO患者的残疾进展相关,而基线时脑实质病变负荷以及脑萎缩改变与MS患者的残疾进展相关。

原始出处:

Liu Y, Duan Y, Huang J, et al.Different patterns of longitudinal brain and spinal cord changes and their associations with disability progression in NMO and MS.Eur Radiol. 2017. DOI: 10.1007/s00330-017-4921-x

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    2018-02-18 jml2009
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    2017-08-20 gj0740
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1889757, encodeId=f2c31889e57de, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sun Feb 18 07:09:00 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1641387, encodeId=0819164138ef6, content=<a href='/topic/show?id=49ba864598c' target=_blank style='color:#2F92EE;'>#致残#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86459, encryptionId=49ba864598c, topicName=致残)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d2622802899, createdName=ms7421025882867189, createdTime=Thu Feb 08 03:09:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1666942, encodeId=52581666942ef, content=<a href='/topic/show?id=5fda90e061e' target=_blank style='color:#2F92EE;'>#视神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90706, encryptionId=5fda90e061e, topicName=视神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14db26078051, createdName=gj0740, createdTime=Sun Aug 20 04:09:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949494, encodeId=de9c1949494a0, content=<a href='/topic/show?id=f237e452185' target=_blank style='color:#2F92EE;'>#神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74521, encryptionId=f237e452185, topicName=神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Thu Oct 26 17:09:00 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650425, encodeId=8207165042507, content=<a href='/topic/show?id=b14384624a3' target=_blank style='color:#2F92EE;'>#脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84624, encryptionId=b14384624a3, topicName=脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06db24008155, createdName=xlysu, createdTime=Sat Mar 17 11:09:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218868, encodeId=6faf2188681d, content=好东西,感谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Wed Jul 05 15:15:40 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483170, encodeId=bac814831e055, content=<a href='/topic/show?id=abcd90e22c3' target=_blank style='color:#2F92EE;'>#视神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90722, encryptionId=abcd90e22c3, topicName=视神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a587885671, createdName=ms8538335253054589, createdTime=Tue Jul 04 15:09:00 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2018-03-17 xlysu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1889757, encodeId=f2c31889e57de, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sun Feb 18 07:09:00 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1641387, encodeId=0819164138ef6, content=<a href='/topic/show?id=49ba864598c' target=_blank style='color:#2F92EE;'>#致残#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86459, encryptionId=49ba864598c, topicName=致残)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d2622802899, createdName=ms7421025882867189, createdTime=Thu Feb 08 03:09:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1666942, encodeId=52581666942ef, content=<a href='/topic/show?id=5fda90e061e' target=_blank style='color:#2F92EE;'>#视神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90706, encryptionId=5fda90e061e, topicName=视神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14db26078051, createdName=gj0740, createdTime=Sun Aug 20 04:09:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949494, encodeId=de9c1949494a0, content=<a href='/topic/show?id=f237e452185' target=_blank style='color:#2F92EE;'>#神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74521, encryptionId=f237e452185, topicName=神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Thu Oct 26 17:09:00 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650425, encodeId=8207165042507, content=<a href='/topic/show?id=b14384624a3' target=_blank style='color:#2F92EE;'>#脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84624, encryptionId=b14384624a3, topicName=脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06db24008155, createdName=xlysu, createdTime=Sat Mar 17 11:09:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218868, encodeId=6faf2188681d, content=好东西,感谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Wed Jul 05 15:15:40 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483170, encodeId=bac814831e055, content=<a href='/topic/show?id=abcd90e22c3' target=_blank style='color:#2F92EE;'>#视神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90722, encryptionId=abcd90e22c3, topicName=视神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a587885671, createdName=ms8538335253054589, createdTime=Tue Jul 04 15:09:00 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-05 shaosai

    好东西,感谢分享!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1889757, encodeId=f2c31889e57de, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sun Feb 18 07:09:00 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1641387, encodeId=0819164138ef6, content=<a href='/topic/show?id=49ba864598c' target=_blank style='color:#2F92EE;'>#致残#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86459, encryptionId=49ba864598c, topicName=致残)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d2622802899, createdName=ms7421025882867189, createdTime=Thu Feb 08 03:09:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1666942, encodeId=52581666942ef, content=<a href='/topic/show?id=5fda90e061e' target=_blank style='color:#2F92EE;'>#视神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90706, encryptionId=5fda90e061e, topicName=视神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14db26078051, createdName=gj0740, createdTime=Sun Aug 20 04:09:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949494, encodeId=de9c1949494a0, content=<a href='/topic/show?id=f237e452185' target=_blank style='color:#2F92EE;'>#神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74521, encryptionId=f237e452185, topicName=神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Thu Oct 26 17:09:00 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650425, encodeId=8207165042507, content=<a href='/topic/show?id=b14384624a3' target=_blank style='color:#2F92EE;'>#脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84624, encryptionId=b14384624a3, topicName=脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06db24008155, createdName=xlysu, createdTime=Sat Mar 17 11:09:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218868, encodeId=6faf2188681d, content=好东西,感谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Wed Jul 05 15:15:40 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483170, encodeId=bac814831e055, content=<a href='/topic/show?id=abcd90e22c3' target=_blank style='color:#2F92EE;'>#视神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90722, encryptionId=abcd90e22c3, topicName=视神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a587885671, createdName=ms8538335253054589, createdTime=Tue Jul 04 15:09:00 CST 2017, time=2017-07-04, status=1, ipAttribution=)]

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