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Moderna公司完整版新冠病毒mRNA疫苗临床试验设计方案

2020-09-20 MedSci原创 MedSci原创

临床试验
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美国疫苗明星公司Moderna，从一开始就成为“众矢之的”，他们从来没有成功研制出来过任何疫苗产品，甚至也没有向FDA提交过他们准备研发的疫苗临床试验申请(IND)。

美国疫苗明星公司Moderna，从一开始就成为“众矢之的”，他们从来没有成功研制出来过任何疫苗产品，甚至也没有向FDA提交过他们准备研发的疫苗临床试验申请(IND)。

一句话，无名之辈在此次疫情中居然“鹤立鸡群”，不仅获得政府数百亿美金投资，还傍上了NIH联合开发最有希望的RNA新型疫苗。

随着疫苗临床试验进入了最关键的III临床试验，越来越多人从各方面打探该RNA疫苗临床试验的设计方案和实施进展情况。

为了获取公众和业界同行信任，Moderna公司通过第三方分享了正在进行的RNA疫苗临床试验设计全套方案和实施手册（共135页）。

从该临床试验设计方案中可以完整地了解RNA类型疫苗的研发和临床试验细节，值得业界同行阅读参考。

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链接：阿斯利康公司新冠病毒疫苗临床试验设计方案

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    2021-11-23 Amyzeng

    没有呢

    0

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    2021-08-20 53224960

    现在没有了吗？

    0

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    2021-01-30 ms6000001967273641

    怎么下载呢

    2

    展开2条回复
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    2020-09-20 lovetcm

    下载了，真详细

    1

    展开1条回复
  5. [GetPortalCommentsPageByObjectIdResponse(id=1073236, encodeId=503a10e323690, content=没有呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211110/9ee0272d8c254405905c9547371b651e/f95e2f3e065b4e0da02277937f066fcc.jpg, createdBy=86815541773, createdName=Amyzeng, createdTime=Tue Nov 23 17:06:16 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1009633, encodeId=2367100963351, content=现在没有了吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=035d1537095, createdName=53224960, createdTime=Fri Aug 20 09:03:35 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921351, encodeId=a78f921351c3, content=怎么下载呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=2, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a325457278, createdName=ms6000001967273641, createdTime=Sat Jan 30 13:08:49 CST 2021, time=2021-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886908, encodeId=bdbf88690858, content=下载了，真详细, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Sep 20 17:59:55 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951054, encodeId=900b951054b6, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b5325425440, createdName=ms1000001495146962, createdTime=Thu Mar 25 15:22:03 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008769, encodeId=97ea2008e692c, content=<a href='/topic/show?id=db6969548d' target=_blank style='color:#2F92EE;'>#eRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6954, encryptionId=db6969548d, topicName=eRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Thu Dec 31 05:53:15 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901723, encodeId=c193901e23c2, content=厉害了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c595438004, createdName=ms2000000954371267, createdTime=Tue Nov 24 12:38:27 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947366, encodeId=5ba5194e36659, content=<a href='/topic/show?id=88d81556543' target=_blank style='color:#2F92EE;'>#RNA疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15565, encryptionId=88d81556543, topicName=RNA疫苗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce072500140, createdName=12498b3em08(暂无昵称), createdTime=Fri May 07 16:53:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887025, encodeId=8d0a88e025c9, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201109/d311346c29d641098dff5f23016e7da7/88055690e20d4cfd85ada57636794e93.jpg, createdBy=12875418351, createdName=ms6000001515816393, createdTime=Mon Sep 21 09:28:38 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886945, encodeId=2b27886945c3, content=好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe95419928, createdName=ms5000000822591910, createdTime=Sun Sep 20 21:33:29 CST 2020, time=2020-09-20, status=1, ipAttribution=)]
    2021-03-25 ms1000001495146962

    好好学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1073236, encodeId=503a10e323690, content=没有呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211110/9ee0272d8c254405905c9547371b651e/f95e2f3e065b4e0da02277937f066fcc.jpg, createdBy=86815541773, createdName=Amyzeng, createdTime=Tue Nov 23 17:06:16 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1009633, encodeId=2367100963351, content=现在没有了吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=035d1537095, createdName=53224960, createdTime=Fri Aug 20 09:03:35 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921351, encodeId=a78f921351c3, content=怎么下载呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=2, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a325457278, createdName=ms6000001967273641, createdTime=Sat Jan 30 13:08:49 CST 2021, time=2021-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886908, encodeId=bdbf88690858, content=下载了，真详细, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Sep 20 17:59:55 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951054, encodeId=900b951054b6, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b5325425440, createdName=ms1000001495146962, createdTime=Thu Mar 25 15:22:03 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008769, encodeId=97ea2008e692c, content=<a href='/topic/show?id=db6969548d' target=_blank style='color:#2F92EE;'>#eRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6954, encryptionId=db6969548d, topicName=eRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Thu Dec 31 05:53:15 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901723, encodeId=c193901e23c2, content=厉害了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c595438004, createdName=ms2000000954371267, createdTime=Tue Nov 24 12:38:27 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947366, encodeId=5ba5194e36659, content=<a href='/topic/show?id=88d81556543' target=_blank style='color:#2F92EE;'>#RNA疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15565, encryptionId=88d81556543, topicName=RNA疫苗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce072500140, createdName=12498b3em08(暂无昵称), createdTime=Fri May 07 16:53:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887025, encodeId=8d0a88e025c9, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201109/d311346c29d641098dff5f23016e7da7/88055690e20d4cfd85ada57636794e93.jpg, createdBy=12875418351, createdName=ms6000001515816393, createdTime=Mon Sep 21 09:28:38 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886945, encodeId=2b27886945c3, content=好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe95419928, createdName=ms5000000822591910, createdTime=Sun Sep 20 21:33:29 CST 2020, time=2020-09-20, status=1, ipAttribution=)]
    2020-12-31 般若傻瓜

    #eRNA#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1073236, encodeId=503a10e323690, content=没有呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211110/9ee0272d8c254405905c9547371b651e/f95e2f3e065b4e0da02277937f066fcc.jpg, createdBy=86815541773, createdName=Amyzeng, createdTime=Tue Nov 23 17:06:16 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1009633, encodeId=2367100963351, content=现在没有了吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=035d1537095, createdName=53224960, createdTime=Fri Aug 20 09:03:35 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921351, encodeId=a78f921351c3, content=怎么下载呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=2, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a325457278, createdName=ms6000001967273641, createdTime=Sat Jan 30 13:08:49 CST 2021, time=2021-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886908, encodeId=bdbf88690858, content=下载了，真详细, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Sep 20 17:59:55 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951054, encodeId=900b951054b6, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b5325425440, createdName=ms1000001495146962, createdTime=Thu Mar 25 15:22:03 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008769, encodeId=97ea2008e692c, content=<a href='/topic/show?id=db6969548d' target=_blank style='color:#2F92EE;'>#eRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6954, encryptionId=db6969548d, topicName=eRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Thu Dec 31 05:53:15 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901723, encodeId=c193901e23c2, content=厉害了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c595438004, createdName=ms2000000954371267, createdTime=Tue Nov 24 12:38:27 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947366, encodeId=5ba5194e36659, content=<a href='/topic/show?id=88d81556543' target=_blank style='color:#2F92EE;'>#RNA疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15565, encryptionId=88d81556543, topicName=RNA疫苗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce072500140, createdName=12498b3em08(暂无昵称), createdTime=Fri May 07 16:53:15 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887025, encodeId=8d0a88e025c9, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201109/d311346c29d641098dff5f23016e7da7/88055690e20d4cfd85ada57636794e93.jpg, createdBy=12875418351, createdName=ms6000001515816393, createdTime=Mon Sep 21 09:28:38 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886945, encodeId=2b27886945c3, content=好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe95419928, createdName=ms5000000822591910, createdTime=Sun Sep 20 21:33:29 CST 2020, time=2020-09-20, status=1, ipAttribution=)]
    2020-11-24 ms2000000954371267

    厉害了

    0

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    2021-05-07 12498b3em08(暂无昵称)

    #RNA疫苗#

    0

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    2020-09-21 ms6000001515816393

    好

    0

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    2020-09-20 ms5000000822591910

    好好好

    0

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