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Eur radiol:摆脱深夜骨痛的困扰!双磷酸盐在治疗骨样骨瘤的价值。

2017-09-24 shaosai MedSci原创

骨样骨瘤系骨内病变,特点是瘤体基质内含钙化程度不同的由骨样组织构成的小核岛(nidus)。另外瘤体中还有含血管丰富的疏松结缔组织形成瘤穴,瘤体四周环以致密硬化骨。骨样骨瘤可引起病儿疼痛。本研究旨在评估双磷酸盐疗法在患有骨样骨瘤(OO)骨痛病人的价值,并评估双磷酸盐诱导的病灶矿化和局部骨髓水肿(BMO)的变化,并将结果发表在Eur radiol上。

骨样骨瘤系骨内病变,特点是瘤体基质内含钙化程度不同的由骨样组织构成的小核岛(nidus)。另外瘤体中还有含血管丰富的疏松结缔组织形成瘤穴,瘤体四周环以致密硬化骨。骨样骨瘤可引起病人疼痛。本研究旨在评估双磷酸盐疗法在患有骨样骨瘤(OO)骨痛病人的价值,并评估双磷酸盐诱导的病灶矿化和局部骨髓水肿(BMO)的变化,并将结果发表在Eur radiol上。

本前瞻性观察研究在2011-2014年进行,纳入了具有经皮穿刺消融或手术切除并发症或切除后复发风险的患者,对其进行每月1次的经静脉双磷酸盐治疗,直到疼痛明显缓解。

本研究共纳入了23名患者,前2名患者接受帕米膦酸二钠治疗,其他21名接受唑来膦酸治疗(平均每例患者进行2.95次输液)。双磷酸盐疗法在19例患者取得了显着疗效,平均疼痛视觉评估量表降低76.7%;共有17例患者(74%)在随后的36个月随访中保持了疼痛缓解状态。CT显示平均病灶密度升高177%(p = 0.001);在磁共振(MRI)的评价中,BMO表面面积平均减少38.4%,信号强度降低30.3%(分别为p = 0.001、 p = 0.000)。

本研究表明,在进行双磷酸盐治疗OO疼痛的23例患者中,有17例患者达到了长期成功疗效。

原始出处:

Bousson V, Leturcq T, Ea HK, et al,An open-label, prospective, observational study of the efficacy of bisphosphonate therapy for painful osteoid osteoma. Eur Radiol. 2017.DOI: 10.1007/s00330-017-5019-1

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1736100, encodeId=01901e361002c, content=<a href='/topic/show?id=79863e54910' target=_blank style='color:#2F92EE;'>#双磷酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37549, encryptionId=79863e54910, topicName=双磷酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=83bc34060689, createdName=小刀医生, createdTime=Mon Jul 30 19:00:00 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248705, encodeId=9f50248e05e3, content=学习了.感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Fri Sep 29 07:05:52 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459915, encodeId=b5711459915ac, content=<a href='/topic/show?id=e50ce3859fe' target=_blank style='color:#2F92EE;'>#磷酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73859, encryptionId=e50ce3859fe, topicName=磷酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8ea6208793, createdName=chenshujs, createdTime=Tue Sep 26 14:00:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247731, encodeId=2a0a24e731be, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Sep 26 05:52:43 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247462, encodeId=806224e46240, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon Sep 25 06:49:35 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247422, encodeId=217f24e42276, content=谢谢分享. , beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Sep 25 05:41:20 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2017-09-29 lofter

    学习了.感谢分享

    0

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1736100, encodeId=01901e361002c, content=<a href='/topic/show?id=79863e54910' target=_blank style='color:#2F92EE;'>#双磷酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37549, encryptionId=79863e54910, topicName=双磷酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=83bc34060689, createdName=小刀医生, createdTime=Mon Jul 30 19:00:00 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248705, encodeId=9f50248e05e3, content=学习了.感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Fri Sep 29 07:05:52 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459915, encodeId=b5711459915ac, content=<a href='/topic/show?id=e50ce3859fe' target=_blank style='color:#2F92EE;'>#磷酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73859, encryptionId=e50ce3859fe, topicName=磷酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8ea6208793, createdName=chenshujs, createdTime=Tue Sep 26 14:00:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247731, encodeId=2a0a24e731be, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Sep 26 05:52:43 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247462, encodeId=806224e46240, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon Sep 25 06:49:35 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247422, encodeId=217f24e42276, content=谢谢分享. , beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Sep 25 05:41:20 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2017-09-26 changjiu

    学习了.谢谢

    0

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    2017-09-25 执着追梦

    学习.谢谢分享

    0

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    2017-09-25 doctorJiangchao

    谢谢分享.

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