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Heart:周围神经病变与糖尿病患者心血管事件风险增加相关

2014-08-20 cath 编译 医学论坛网

英国学者们对周围神经病变(PN)与突发心血管事件的关联性以及PN至何种程度可能改善2型糖尿病人群的危险预测进行了探讨。结果表明,PN与糖尿病人群首次心血管事件风险增加具有相关性。相关论文8月5 日在线发表于《心脏》(Heart)杂志。 该研究纳入13 043例无心血管疾病(CVD)的2型糖尿病受试者,记录随访30个月期间的突发CVD事件。确定这些患者基线时心血管危险因素和PN状态,利用Cox回归

英国学者们对周围神经病变(PN)与突发心血管事件的关联性以及PN至何种程度可能改善2型糖尿病人群的危险预测进行了探讨。结果表明,PN与糖尿病人群首次心血管事件风险增加具有相关性。相关论文8月5 日在线发表于《心脏》(Heart)杂志。

该研究纳入13 043例无心血管疾病(CVD)的2型糖尿病受试者,记录随访30个月期间的突发CVD事件。确定这些患者基线时心血管危险因素和PN状态,利用Cox回归分析PN与突发CVD事件的相关性。

结果显示,发生任何原因死亡数和非致命性CVD事件分别为407例和399例。在校正年龄、性别、种族、收缩压、胆固醇、体质指数、糖化血红蛋白、吸烟状态和他汀类药物及降压药物的应用后,PN与突发CVD事件具有相关性(HR 1.33;P=0.04)。

原始出处:

Brownrigg JR1, de Lusignan S2, McGovern A2, Hughes C1, Thompson MM1, Ray KK1, Hinchliffe RJ1.Peripheral neuropathy and the risk of cardiovascular events in type 2 diabetes mellitus.Heart. 2014 Aug 5. pii: heartjnl-2014-305657. doi: 10.1136/heartjnl-2014-305657. [Epub ahead of print]

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    2015-04-11 x35042875

    糖尿病肾病进展风险的关系没有发现。

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href='/topic/show?id=3c3d51e4459' target=_blank style='color:#2F92EE;'>#心血管事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51744, encryptionId=3c3d51e4459, topicName=心血管事件风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355904, encodeId=cc38135590472, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473823, encodeId=59ea14e382399, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491225, encodeId=721e14912255e, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=)]
    2014-09-07 DD2012

    机制是啥

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=20635, encodeId=491e206354c, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:23:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643348, encodeId=eec71643348cc, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Sat Jul 11 11:32:00 CST 2015, time=2015-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748233, encodeId=13871e48233a2, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Thu May 07 19:32:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11537, encodeId=9a401153e02, content=机制是啥, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=766d107293, createdName=DD2012, createdTime=Sun Sep 07 00:05:00 CST 2014, time=2014-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11331, encodeId=88de11331ba, content=周围神经病变的对于心脏及其他器官都有影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Tue Aug 26 18:42:00 CST 2014, time=2014-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11251, encodeId=006b11251d7, content=说明心血管事件的发生与心脏交感副交感自动调节神经系统的功能降低相关?, beContent=null, objectType=article, channel=null, level=null, likeNumber=226, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Sun Aug 24 17:24:00 CST 2014, time=2014-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287614, encodeId=0c58128e614f4, content=<a href='/topic/show?id=3c3d51e4459' target=_blank style='color:#2F92EE;'>#心血管事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51744, encryptionId=3c3d51e4459, topicName=心血管事件风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355904, encodeId=cc38135590472, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473823, encodeId=59ea14e382399, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491225, encodeId=721e14912255e, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=)]
    2014-08-26 rosa00tong

    周围神经病变的对于心脏及其他器官都有影响

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=20635, encodeId=491e206354c, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:23:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643348, encodeId=eec71643348cc, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Sat Jul 11 11:32:00 CST 2015, time=2015-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748233, encodeId=13871e48233a2, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Thu May 07 19:32:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11537, encodeId=9a401153e02, content=机制是啥, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=766d107293, createdName=DD2012, createdTime=Sun Sep 07 00:05:00 CST 2014, time=2014-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11331, encodeId=88de11331ba, content=周围神经病变的对于心脏及其他器官都有影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Tue Aug 26 18:42:00 CST 2014, time=2014-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11251, encodeId=006b11251d7, content=说明心血管事件的发生与心脏交感副交感自动调节神经系统的功能降低相关?, beContent=null, objectType=article, channel=null, level=null, likeNumber=226, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Sun Aug 24 17:24:00 CST 2014, time=2014-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287614, encodeId=0c58128e614f4, content=<a href='/topic/show?id=3c3d51e4459' target=_blank style='color:#2F92EE;'>#心血管事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51744, encryptionId=3c3d51e4459, topicName=心血管事件风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355904, encodeId=cc38135590472, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473823, encodeId=59ea14e382399, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491225, encodeId=721e14912255e, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=)]
    2014-08-24 rosa00tong

    说明心血管事件的发生与心脏交感副交感自动调节神经系统的功能降低相关?

    0

  7. 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time=2014-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11331, encodeId=88de11331ba, content=周围神经病变的对于心脏及其他器官都有影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Tue Aug 26 18:42:00 CST 2014, time=2014-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11251, encodeId=006b11251d7, content=说明心血管事件的发生与心脏交感副交感自动调节神经系统的功能降低相关?, beContent=null, objectType=article, channel=null, level=null, likeNumber=226, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Sun Aug 24 17:24:00 CST 2014, time=2014-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287614, encodeId=0c58128e614f4, content=<a href='/topic/show?id=3c3d51e4459' target=_blank style='color:#2F92EE;'>#心血管事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51744, encryptionId=3c3d51e4459, topicName=心血管事件风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355904, encodeId=cc38135590472, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473823, encodeId=59ea14e382399, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491225, encodeId=721e14912255e, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=)]
  8. 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href='/topic/show?id=3c3d51e4459' target=_blank style='color:#2F92EE;'>#心血管事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51744, encryptionId=3c3d51e4459, topicName=心血管事件风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355904, encodeId=cc38135590472, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473823, encodeId=59ea14e382399, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491225, encodeId=721e14912255e, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=)]
    2014-08-22 zhaojie88
  9. 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  10. 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createdBy=1ab48885684, createdName=axin012, createdTime=Fri Aug 22 00:32:00 CST 2014, time=2014-08-22, status=1, ipAttribution=)]
    2014-08-22 axin012

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