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Crit Care:液体负平衡危重症患者液体摄入与死亡率的关系如何?

2017-05-13 xing.T MedSci原创

在严重的负性FB患者中,增加的液体摄入量和尿量均与医院死亡率降低有关。然而,相比轻微的FB,实现更多的负性FB与死亡率降低并不相关。

与正性体液平衡(FB)相比,负性FB与危重病患者改善的临床结局相关。然而,至于是否实现更多的负性FB可以进一步改善结局还没有被调查。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,研究人员旨在调查是否更多的负性FB和限制液体摄入量与改善危重患者预后相关。

研究人员提取了多参数重症监护智能监测III数据库的数据。患者在入住重症监护病房(ICU)48小时后达到负性FB被进行筛查。该研究的主要转归为医院死亡率。Logistic模型被建立用于探讨FB、液体摄入量和死亡率之间的相关性,使用FB和液体摄入量(四个层次)作为设计变量,并使用线性样条函数法进行分析。

符合纳入标准的有2068例患者,相比于轻微的负性FB(1级),2级(比值比为0.88,95%可信区间为0.69-1.11)和第3级(比值比为0.79,95%可信区间为0.65-1.11)FB患者的死亡率有下降趋势,但是,只有极端负性FB(4级)具有显着性(比值比为0.56,95%可信区间为0.33-0.95)。在入住ICU后48小时内,液体摄入和尿量均呈均匀分布。液体摄入量与医院死亡率呈负相关,比值比从2级(比值比为0.73,95%可信区间为0.56-0.96)到4级(比值比为0.47,95%可信区间为0.30-0.74)逐步下降,以1级为参考组。尿量也表现出类似的模式。利尿剂的使用与这两种模型的死亡率较高相关。

在严重的负性FB患者中,增加的液体摄入量和尿量均与医院死亡率降低有关。然而,相比轻微的FB,实现更多的负性FB与死亡率降低并不相关。

原始出处:

Yanfei Shen,et al. Association between fluid intake and mortality in critically ill patients with negative fluid balance: a retrospective cohort study.Critical Care.2017. https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1692-3

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    2017-05-15 明天会更好!

    学习过了,分享分享!

    0

  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 14 08:24:43 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-15 1e10c84am36(暂无匿称)

    文章很好,拜读了

    0

  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 14 08:24:43 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 tanxingdoctor

    学习啦,谢谢分享

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 14 08:24:43 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 cqykthl

    体液和电解质平衡很重要

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun May 14 08:58:07 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197889, encodeId=913219e8898e, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun May 14 08:40:46 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197874, encodeId=c6fe19e87420, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 14 08:24:43 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 dhzzm

    学习了分享了,正在循证中

    0

  8. 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likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Sun May 14 22:55:25 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197946, encodeId=f53119e94654, content=学习了分享了,正在循证中, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun May 14 11:23:30 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197910, encodeId=ff5d19e91049, content=不错的解释,终于懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun May 14 08:58:07 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197889, encodeId=913219e8898e, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun May 14 08:40:46 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197874, encodeId=c6fe19e87420, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 14 08:24:43 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 1e1b8538m79(暂无匿称)

    不错的解释,终于懂了

    0

  9. 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likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Sun May 14 22:55:25 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197946, encodeId=f53119e94654, content=学习了分享了,正在循证中, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun May 14 11:23:30 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197910, encodeId=ff5d19e91049, content=不错的解释,终于懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun May 14 08:58:07 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197889, encodeId=913219e8898e, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun May 14 08:40:46 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197874, encodeId=c6fe19e87420, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 14 08:24:43 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 龙胆草

    学习了,谢谢分享

    0

  10. 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likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Sun May 14 22:55:25 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197946, encodeId=f53119e94654, content=学习了分享了,正在循证中, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun May 14 11:23:30 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197910, encodeId=ff5d19e91049, content=不错的解释,终于懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun May 14 08:58:07 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197889, encodeId=913219e8898e, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun May 14 08:40:46 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197874, encodeId=c6fe19e87420, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun May 14 08:24:43 CST 2017, time=2017-05-14, status=1, ipAttribution=)]
    2017-05-14 天涯183

    非常好的文章,学习了,很受益

    0

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JBJS:固定与旋转平台全膝置换中期疗效相当

尽管固定平台(Fixed-Bearing, FB)全膝关节置换术后临床成功率高,无论是年轻还是老年患者术后10-15年时假体生存率均可高达90%-98%,然而与这种类型的假体相关的聚乙烯衬垫磨损和骨溶解会导致的假体松动及失败,由此研究者设计了旋转平台(Mobile-Bearing, MB)式假体以试图解决这些问题。 MB设计在理论上相对于FB设计有一定的优势,包括具有自动调节以适应和复制更接

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