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Strauer干细胞治疗心脏病研究存在学术不端证据

2014-02-27 孙学军 科学网博客

Bodo-Eckehard Strauer 教授出生于1943年1月16日,是德国杜塞尔多夫大学心脏病学家,他最著名的学术成就是关于干细胞治疗心脏病。在研究中,他采集患者自体骨髓干细胞,然 后注射到患者冠状动脉,这种治疗可以改善心脏病患者的心功能。2001年他最早发表了该类文章,奠定了在这一领域的地位和影响力。这一贡献开创了自体干细 胞治疗心脏病的新领域,先后有数10家大学和医院迅


Bodo-Eckehard Strauer 教授出生于1943年1月16日,是德国杜塞尔多夫大学心脏病学家,他最著名的学术成就是关于干细胞治疗心脏病。在研究中,他采集患者自体骨髓干细胞,然 后注射到患者冠状动脉,这种治疗可以改善心脏病患者的心功能。2001年他最早发表了该类文章,奠定了在这一领域的地位和影响力。这一贡献开创了自体干细 胞治疗心脏病的新领域,先后有数10家大学和医院迅速跟进这一研究领域,许多相关商业产品相继问世。他的实验室也先后报道干细胞可以各种心脏疾病都具有理 想治疗效果,发表了大量相关学术论文,一直在这个领域领跑,极大地推动了干细胞治疗心脏病的快速发展。

不过,德国学术界一直对 Strauer教授干细胞的研究表示怀疑。最典型是《国际心脏病学杂志》上一篇文章,文章详细分析了Strauer团队的 48 篇论文,提出了系列疑问,包括统计学错误以及论文中描述不同数量的患者却得出相同答案等问题。文章还系统地罗列了这些论文中众多自相矛盾的信息,文章说在 一组组的自相矛盾的结果中,肯定存在不真实的。例如有些论文中,有的论文说这些病人是随机选择,然而在另一批患者不是随机分组,却也得出完全相同治疗效果 的结论。英国伦敦帝国学院的心脏病专家 Darrel Francis告诉《自然》杂志:“分析这些对照组实验结果时,发现存在显著性差异”。Francis在一次新闻发布会上说,这些表面上全面而确定的证据 逐渐露出破绽,对这一研究了解越多,越觉得不可思议。对这些研究是否遵循随机对照的原则,甚至患者的具体数量都表示怀疑。

2009年 Strauer从杜塞尔多夫大学退休,针对学术界对Strauer研究的质疑,2012年杜塞尔多夫大学成立的专门的调查委员会。根据《自然》杂志最近报 道,经过历时将近2年的调查,该委员会2014年2月24日提交了调查报告,据透漏调查发现Strauer在他发表的众多临床研究论文中,存在学术不端行 为的证据,但目前仍没有公开详细信息,对参与该研究的537名患者是否经过药物临床试验质量管理规范,德国药品法的规定伦理审查等相关质疑也无法了解。杜 塞尔多夫大学医院CEO Benedikt Pannen说,临床研究调查报告已上交给城市公共检察官。

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    2015-07-15 飞马

    0

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    2015-01-08 bsmagic9140
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    2014-03-19 mark037100

    又一次可能告诫学术界跟风产生的笑料

    0

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    2014-03-06 112.65.244.92

    使人想起当年俺们的干细胞研究就否定“干细胞变成心肌细胞”假说。国内巨多研究证明干细胞变成了心肌细胞,尼玛扯淡,our结果就是打入干细胞可以使得局部炎症得到缓解,并没有那么神,但被噤声。任何权威都要经得起质疑和检验,但是学者昏了头......

    0

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    2014-02-27 BENNY325

    任何权威都要经得起质疑和检验

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