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Nat Rev Microbiol:宏基因组关联分析与微生物组

2016-07-13 MedSci MedSci原创

我们体内生活着不计其数的微生物,它们组成的生态系统就是微生物组。近年来人们发现这些微生物对人体健康有着重要的影响,微生物组研究因此受到了极大的重视,甚至被称为是人体的“第二基因组”。宏基因组关联分析(Metagenome-wide association studies,MWAS)是挖掘微生物组宝藏的有力工具,可以高分辨率研究微生物组与复杂疾病的关联,比如二型糖尿病、肥胖症、肝硬化、大肠癌和类风湿

我们体内生活着不计其数的微生物,它们组成的生态系统就是微生物组。近年来人们发现这些微生物对人体健康有着重要的影响,微生物组研究因此受到了极大的重视,甚至被称为是人体的“第二基因组”。


宏基因组关联分析(Metagenome-wide association studies,MWAS)是挖掘微生物组宝藏的有力工具,可以高分辨率研究微生物组与复杂疾病的关联,比如二型糖尿病、肥胖症、肝硬化、大肠癌和类风湿性关节炎。MWAS不仅能鉴定丰度发生变化的细菌种类,还能够判断细菌功能的增强或减弱。

iCarbonX公司CEO王俊和华大基因BGI的Huijue Jia最近在Nature Reviews Microbiology杂志上发表文章,介绍了MWAS研究最近的一些发现,探讨了这些发现对疾病预防、诊断和治疗的潜在影响。文章指出,我们需要在人类微生物组中更好地描述细菌生物学特性,这样才能理解MWAS鉴定的细菌菌株与疾病有何关系。

微生物组参与了许多重要的机体功能,比如消化食物、合成营养物质和抵御疾病。许多人类疾病都与微生物组失衡有关,但揭示其中的因果关系并不容易。因为微生物组是由数百种细菌组成的复杂生态系统,同种细菌的不同菌株也存在显著的遗传差异。

原始出处:

Wang J, Jia H. Metagenome-wide association studies: fine-mining the microbiome. Nat Rev Microbiol. 2016 Jul 11. doi: 10.1038/nrmicro.2016.83

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    2016-07-15 liye789132251
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    2017-06-09 xjy02
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    2016-10-17 sunylz
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  8. [GetPortalCommentsPageByObjectIdResponse(id=1881178, encodeId=427a18811e806, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jul 15 02:33:00 CST 2016, time=2016-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084157, encodeId=0359208415e7e, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Jun 09 18:33:00 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767026, encodeId=7a211e6702668, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sun Dec 25 16:33:00 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857384, encodeId=d45e185e384d4, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Jul 31 12:33:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824674, encodeId=f9c618246e4a2, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Sep 04 10:33:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917305, encodeId=f908191e305f0, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Oct 17 08:33:00 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372933, encodeId=1a4a13e293336, content=<a href='/topic/show?id=e7ba458950b' target=_blank style='color:#2F92EE;'>#宏基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45895, encryptionId=e7ba458950b, topicName=宏基因组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Fri Jul 15 04:33:00 CST 2016, time=2016-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382364, encodeId=b11e138236486, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Fri Jul 15 04:33:00 CST 2016, time=2016-07-15, status=1, ipAttribution=)]
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