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Thorax:肺癌、遗传易感性和吸烟:双胞胎研究

2017-10-30 xiangting MedSci原创

遗传性的作用随着年龄的增长而降低。吸烟情况不一致的双胞胎分析证实了吸烟会导致肺癌。

这项研究目的是在考虑吸烟状况的同时,寻找肺癌的遗传性和环境性病因。

4个北欧双胞胎队列(43 512例单卵双生(MZ)和71 895例同性双卵(DZ) 双胞胎个体)在癌症诊断前有吸烟数据。使用时间-事件分析来计算审查和死亡的竞争风险,以估计不同吸烟状况发生肺癌的发病率、一致性风险和遗传性。

在中位数为28.5年的随访中,共有1508例偶发性肺癌。在均患肺癌的30对MZ和28对DZ中,几乎所有人基线时都是目前吸烟者,只有1对从不吸烟。在曾经吸烟者中,与MZ和DZ双胞胎的累积发生率相比,肺癌的病例一致性显著升高,即在某一特定年龄之前双胞胎条件性患肺癌的风险。这一比例,相对复发风险,在MZ中随年龄显著下降,而DZ双胞胎保持不变。目前吸烟者的肺癌遗传性为0.41(95%CI 0.26-0.56),而曾经吸烟者的肺癌遗传性为0.37(95%CI 0.25-0.49)。对于吸烟情况不一致的双胞胎,MZ中曾经吸烟者与从不吸烟的胞兄比较肺癌HR为5.4(95%CI 2.1-14.0),DZ中为5.0(95%CI为3.2-7.9)。

遗传性的作用随着年龄的增长而降低。吸烟情况不一致的双胞胎分析证实了吸烟会导致肺癌。

原始出处:

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1967331, encodeId=5815196e33114, content=<a href='/topic/show?id=a0553e5800a' target=_blank style='color:#2F92EE;'>#双胞胎研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37580, encryptionId=a0553e5800a, topicName=双胞胎研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Thu Nov 23 02:28:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279388, encodeId=8c2a2e938843, content=学习了谢谢作者分享!学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Jan 17 13:18:26 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257857, encodeId=2bd225e8572d, content=可贵之处在于.入组人数多(是双胞胎!).随访时间长(近30年!).不容易啊!致敬!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dbbe2184942, createdName=杏林一叶, createdTime=Wed Nov 01 19:28:28 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257854, encodeId=5be825e854d4, content=很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dbbe2184942, createdName=杏林一叶, createdTime=Wed Nov 01 19:23:03 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393904, encodeId=3eed1393904fd, content=<a href='/topic/show?id=32313e5765b' target=_blank style='color:#2F92EE;'>#双胞胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37576, encryptionId=32313e5765b, topicName=双胞胎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Wed Nov 01 06:28:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454705, encodeId=85f81454e055d, content=<a href='/topic/show?id=7467951e7b1' target=_blank style='color:#2F92EE;'>#遗传易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95177, encryptionId=7467951e7b1, topicName=遗传易感性)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=1a435588697, createdName=kcb071, createdTime=Wed Nov 01 06:28:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460537, encodeId=0dff146053e6b, content=<a href='/topic/show?id=36a7596628a' target=_blank style='color:#2F92EE;'>#易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59662, encryptionId=36a7596628a, topicName=易感性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6af6344165, createdName=FukaiBao, createdTime=Wed Nov 01 06:28:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257450, encodeId=808a25e45015, content=学习学习.很不错., beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIxvMP6OXzUiaGH5MkDQlW0hczROZxec1gZjfZ52EtN6aG9t0uDZq2A5xmf9FWMa4tZib4qoYnledFg/132, createdBy=9d6c2167401, createdName=hanmeijinxiu, createdTime=Tue Oct 31 08:31:16 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257262, encodeId=05d425e26298, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Oct 30 18:25:57 CST 2017, time=2017-10-30, status=1, ipAttribution=)]
    2018-01-17 1e145228m78(暂无匿称)

    学习了谢谢作者分享!学习了谢谢作者分享!

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1967331, encodeId=5815196e33114, content=<a href='/topic/show?id=a0553e5800a' target=_blank style='color:#2F92EE;'>#双胞胎研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37580, encryptionId=a0553e5800a, topicName=双胞胎研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Thu Nov 23 02:28:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279388, encodeId=8c2a2e938843, content=学习了谢谢作者分享!学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Jan 17 13:18:26 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257857, encodeId=2bd225e8572d, content=可贵之处在于.入组人数多(是双胞胎!).随访时间长(近30年!).不容易啊!致敬!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dbbe2184942, createdName=杏林一叶, createdTime=Wed Nov 01 19:28:28 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257854, encodeId=5be825e854d4, content=很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dbbe2184942, createdName=杏林一叶, createdTime=Wed Nov 01 19:23:03 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393904, encodeId=3eed1393904fd, content=<a href='/topic/show?id=32313e5765b' target=_blank style='color:#2F92EE;'>#双胞胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37576, encryptionId=32313e5765b, topicName=双胞胎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Wed Nov 01 06:28:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454705, encodeId=85f81454e055d, content=<a href='/topic/show?id=7467951e7b1' target=_blank style='color:#2F92EE;'>#遗传易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95177, encryptionId=7467951e7b1, topicName=遗传易感性)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=1a435588697, createdName=kcb071, createdTime=Wed Nov 01 06:28:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460537, encodeId=0dff146053e6b, content=<a href='/topic/show?id=36a7596628a' target=_blank style='color:#2F92EE;'>#易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59662, encryptionId=36a7596628a, topicName=易感性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6af6344165, createdName=FukaiBao, createdTime=Wed Nov 01 06:28:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257450, encodeId=808a25e45015, content=学习学习.很不错., beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIxvMP6OXzUiaGH5MkDQlW0hczROZxec1gZjfZ52EtN6aG9t0uDZq2A5xmf9FWMa4tZib4qoYnledFg/132, createdBy=9d6c2167401, createdName=hanmeijinxiu, createdTime=Tue Oct 31 08:31:16 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257262, encodeId=05d425e26298, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Oct 30 18:25:57 CST 2017, time=2017-10-30, status=1, ipAttribution=)]
    2017-11-01 杏林一叶

    可贵之处在于.入组人数多(是双胞胎!).随访时间长(近30年!).不容易啊!致敬!

    0

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    2017-11-01 杏林一叶

    很好!

    0

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    2017-10-31 hanmeijinxiu

    学习学习.很不错.

    0

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    2017-10-30 131****1460

    学习了受益匪浅

    0

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鉴于职业暴露在亚群中的最小作用,研究人员得出结论:即职业暴露对从不吸烟的肺癌患者分子模式影响十分轻微。特别是石棉暴露的参与者EGFR突变的几率很低。

肺癌早期诊断新技术及临床评价

早期诊断、早期治疗是改善肺癌患者预后的关键环节。总体来说,肺癌早期诊断现状很不理想,大多数患者就诊时已是晚期。近年来,肺癌早期诊断技术有了明显进展,尤其表现在以下几个方面。

第十五届全国肺癌大会:熊建萍教授:精准靶向治疗新进展令人惊喜

2017年10月26-28日,第十五届全国肺癌大会在江西南昌顺利召开,此次大会由中国抗癌协会肺癌专业委员会主办,南昌大学第一附属医院、江西省抗癌协会肺癌专业委员会承办,肿瘤资讯有幸邀请到熊建萍教授,请她为大家谈谈承办体会及此次大会的亮点。

Carcinogenesis:肺癌新突破:科学家首次确定肺癌形成的基因标志物

众所周知,环境和遗传危险因素可以导致肺癌的发展,其中,吸烟是导致肺癌的最大元凶。达特茅斯大学研究小组的科学家们进行了一项研究,结果显示吸烟与基因交互是肺癌形成中的关键环节。

瑜伽成为肺癌患者及其照护者的有效支持疗法

作为高发且死亡率最高的恶性肿瘤之一,肺癌已经成为肿瘤学中的研究热点。在乏善可陈的疗法之中,支持性疗法或可另辟蹊径,虽不能显着延长肺癌患者生存期,但是改善患者生活质量也是弥足珍贵的。

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