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PLos One:房颤患者使用抗凝药物的现状如何?

2017-04-17 MedSci MedSci原创

此前的研究发现,在心房颤动(AF)患者中,卒中前的抗凝治疗率较低。近期,一篇发表在杂志PLos One上的研究在已知具有高风险的人群中进行了研究,评估了基于人群的AF相关卒中患者的数据,并检查了卒中前房颤的管理变化以及治疗次数不佳的原因。此项研究的研究人群为南伦敦卒中登记册(SLSR),其是一个持续的以人口为基础的登记册,记录了患者一生的中风情况。自1995年至2014年期间调查了AF的患病率和中

此前的研究发现,在心房颤动(AF)患者中,卒中前的抗凝治疗率较低。


近期,一篇发表在杂志PLos One上的研究在已知具有高风险的人群中进行了研究,评估了基于人群的AF相关卒中患者的数据,并检查了卒中前房颤管理变化以及治疗次数不佳的原因。

此项研究的研究人群为南伦敦卒中登记册(SLSR),其是一个持续的以人口为基础的登记册,记录了患者一生的中风情况。自1995年至2014年期间调查了AF的患病率和中风前使用预防血栓药物的趋势。结果进行多变量逻辑回归分析,以评估与适当管理相关的因素。

此项研究结果显示:在登记的5041名患者中,816例(16.2%)在卒中前被诊断为房颤。AF相关卒中在黑加拿大和黑非洲患者中大幅增加,占1995-1998年总体队列的5%,至2011-2014年增加到25%(p <0.001)。

高危卒中AF患者的抗凝处方(CHADS2评分[> = 2])从9%(1995-1998年)增加到30%(2011-2014年)(p <0.001)。使用抗血小板治疗在所有时间段(43%至64%的高危患者)中更常见。老年患者(> 65岁)使用抗凝剂的可能性明显较低;种族、性别与抗凝无关。

此项研究结果表明:大多数AF相关的中风发生在可以预测的高风险的人群中,但目前尚未规定最佳预防治疗。老年人尽管卒中风险高,但仍然很少使用抗凝剂治疗。

原始出处:
Jain V, Marshall IJ, et al. Trends in the prevalence and management of pre-stroke atrial fibrillation, the South London Stroke Register, 1995-2014. PLoS One. 2017 Apr 14;12(4):e0175980. doi: 10.1371/journal.pone.0175980. eCollection 2017.

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    2017-04-24 flysky120

    房颤的药物,慢慢学习

    0

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    2017-04-17 Albert Wu

    大多数AF相关的中风发生在可以预测的高风险的人群中,但目前尚未规定最佳预防治疗。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1789927, encodeId=46a61e899279b, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Jun 23 08:50:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190125, encodeId=ccf81901257f, content=房颤的药物,慢慢学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Mon Apr 24 10:42:38 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614351, encodeId=dfe31614351ec, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Apr 19 03:50:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188283, encodeId=be8d18828340, content=大多数AF相关的中风发生在可以预测的高风险的人群中,但目前尚未规定最佳预防治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd301464769, createdName=Albert Wu, createdTime=Mon Apr 17 18:30:27 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188237, encodeId=d5e518823e66, content=希望多些此类知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3ia08g8CeyBbh9ZJA3uOmXGicNRf5EgF8K0LBmd9FE8HMMia9LsFfB93UR68micicia9u3kYKT7XYIb5epiaOupgzEwibq/0, createdBy=bde71954073, createdName=Sunny Zhao, createdTime=Mon Apr 17 12:55:33 CST 2017, time=2017-04-17, status=1, ipAttribution=)]
    2017-04-17 Sunny Zhao

    希望多些此类知识

    0

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